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Medications for Major Depressive Disorder

The medications listed below are related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Wellbutrin XL 7.4 129 reviews for Wellbutrin XL to treat Major Depressive Disorder Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Zoloft 6.8 144 reviews for Zoloft to treat Major Depressive Disorder Rx C N X
Generic name:
sertraline systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bupropion 6.9 438 reviews for bupropion to treat Major Depressive Disorder Rx C N X
Generic name:
bupropion systemic
Brand names:
Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion SR, Forfivo XL
Drug class:
miscellaneous antidepressants, smoking cessation agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Prozac 6.4 102 reviews for Prozac to treat Major Depressive Disorder Rx C N X
Generic name:
fluoxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Lexapro 6.5 121 reviews for Lexapro to treat Major Depressive Disorder Rx C N X
Generic name:
escitalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Trintellix 6.2 473 reviews for Trintellix to treat Major Depressive Disorder Rx C N X
Generic name:
vortioxetine systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Rexulti 6.6 249 reviews for Rexulti to treat Major Depressive Disorder Rx N X
Generic name:
brexpiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Cymbalta 6.2 123 reviews for Cymbalta to treat Major Depressive Disorder Rx C N X
Generic name:
duloxetine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
sertraline 6.8 231 reviews for sertraline to treat Major Depressive Disorder Rx C N X
Generic name:
sertraline systemic
Brand name:
Zoloft
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Abilify 6.1 140 reviews for Abilify to treat Major Depressive Disorder Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Vraylar 7.1 47 reviews for Vraylar to treat Major Depressive Disorder Rx N X
Generic name:
cariprazine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Effexor XR 6.6 117 reviews for Effexor XR to treat Major Depressive Disorder Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Pristiq 6.3 157 reviews for Pristiq to treat Major Depressive Disorder Rx C N X
Generic name:
desvenlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
trazodone 6.3 33 reviews for trazodone to treat Major Depressive Disorder Rx C N X
Generic name:
trazodone systemic
Brand name:
Raldesy
Drug class:
phenylpiperazine antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
brexpiprazole 6.5 259 reviews for brexpiprazole to treat Major Depressive Disorder Rx N X
Generic name:
brexpiprazole systemic
Brand name:
Rexulti
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
fluoxetine 6.6 141 reviews for fluoxetine to treat Major Depressive Disorder Rx C N X
Generic name:
fluoxetine systemic
Brand name:
Prozac
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Remeron 7.4 65 reviews for Remeron to treat Major Depressive Disorder Rx C N X
Generic name:
mirtazapine systemic
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Wellbutrin SR 7.9 25 reviews for Wellbutrin SR to treat Major Depressive Disorder Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
venlafaxine 6.5 263 reviews for venlafaxine to treat Major Depressive Disorder Rx C N X
Generic name:
venlafaxine systemic
Brand names:
Effexor XR, Effexor
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
cariprazine 7.1 50 reviews for cariprazine to treat Major Depressive Disorder Rx N X
Generic name:
cariprazine systemic
Brand name:
Vraylar
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
escitalopram 6.6 173 reviews for escitalopram to treat Major Depressive Disorder Rx C N X
Generic name:
escitalopram systemic
Brand name:
Lexapro
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
mirtazapine 7.0 193 reviews for mirtazapine to treat Major Depressive Disorder Rx C N X
Generic name:
mirtazapine systemic
Brand names:
Remeron, Remeron SolTab
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
duloxetine 6.2 153 reviews for duloxetine to treat Major Depressive Disorder Rx C N X
Generic name:
duloxetine systemic
Brand names:
Cymbalta, Irenka
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Viibryd 5.5 218 reviews for Viibryd to treat Major Depressive Disorder Rx C N X
Generic name:
vilazodone systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Effexor 5.8 64 reviews for Effexor to treat Major Depressive Disorder Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
aripiprazole 6.2 159 reviews for aripiprazole to treat Major Depressive Disorder Rx C N X
Generic name:
aripiprazole systemic
Brand names:
Abilify, Opipza
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
quetiapine 6.6 62 reviews for quetiapine to treat Major Depressive Disorder Rx C N X
Generic name:
quetiapine systemic
Brand name:
Seroquel XR
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Seroquel XR 6.4 16 reviews for Seroquel XR to treat Major Depressive Disorder Rx C N X
Generic name:
quetiapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Paxil 7.2 36 reviews for Paxil to treat Major Depressive Disorder Rx D N X
Generic name:
paroxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
nefazodone 8.9 31 reviews for nefazodone to treat Major Depressive Disorder Rx C N X
Generic name:
nefazodone systemic
Drug class:
phenylpiperazine antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Auvelity 8.6 126 reviews for Auvelity to treat Major Depressive Disorder Rx N X
Generic name:
bupropion / dextromethorphan systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Zyprexa 5.2 25 reviews for Zyprexa to treat Major Depressive Disorder Rx C N X
Generic name:
olanzapine systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
vortioxetine 6.3 598 reviews for vortioxetine to treat Major Depressive Disorder Rx C N X
Generic name:
vortioxetine systemic
Brand name:
Trintellix
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Fetzima 5.3 106 reviews for Fetzima to treat Major Depressive Disorder Rx C N X
Generic name:
levomilnacipran systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
paroxetine 7.5 56 reviews for paroxetine to treat Major Depressive Disorder Rx D N X
Generic name:
paroxetine systemic
Brand names:
Paxil, Paxil CR
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Aplenzin 8.5 6 reviews for Aplenzin to treat Major Depressive Disorder Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
desvenlafaxine 6.3 177 reviews for desvenlafaxine to treat Major Depressive Disorder Rx C N X
Generic name:
desvenlafaxine systemic
Brand name:
Pristiq
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
doxepin 7.6 5 reviews for doxepin to treat Major Depressive Disorder Rx N N X
Generic name:
doxepin systemic
Drug class:
miscellaneous anxiolytics, sedatives and hypnotics, tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Budeprion SR 6.0 2 reviews for Budeprion SR to treat Major Depressive Disorder Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
olanzapine 5.8 53 reviews for olanzapine to treat Major Depressive Disorder Rx C N X
Generic name:
olanzapine systemic
Brand name:
Zyprexa
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Paxil CR 10 3 reviews for Paxil CR to treat Major Depressive Disorder Rx D N X
Generic name:
paroxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Forfivo XL Rate Add review Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
vilazodone 5.5 239 reviews for vilazodone to treat Major Depressive Disorder Rx C N X
Generic name:
vilazodone systemic
Brand name:
Viibryd
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Irenka Rate Add review Rx C N X
Generic name:
duloxetine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
Raldesy Rate Add review Rx C N X
Generic name:
trazodone systemic
Drug class:
phenylpiperazine antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Spravato 7.2 58 reviews for Spravato to treat Major Depressive Disorder Rx 3 X
Generic name:
esketamine systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bupropion / dextromethorphan 8.5 128 reviews for bupropion / dextromethorphan to treat Major Depressive Disorder Rx N X
Generic name:
bupropion / dextromethorphan systemic
Brand name:
Auvelity
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
fluoxetine / olanzapine 7.8 12 reviews for fluoxetine / olanzapine to treat Major Depressive Disorder Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Brand name:
Symbyax
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Remeron SolTab 7.0 1 review for Remeron SolTab to treat Major Depressive Disorder Rx C N X
Generic name:
mirtazapine systemic
Drug class:
tetracyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Emsam 6.6 16 reviews for Emsam to treat Major Depressive Disorder Rx C N X
Generic name:
selegiline systemic
Drug class:
monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
esketamine 7.1 60 reviews for esketamine to treat Major Depressive Disorder Rx 3 X
Generic name:
esketamine systemic
Brand name:
Spravato
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Opipza Rate Add review Rx C N X
Generic name:
aripiprazole systemic
Drug class:
atypical antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Symbyax 7.0 8 reviews for Symbyax to treat Major Depressive Disorder Rx C N X
Generic name:
fluoxetine / olanzapine systemic
Drug class:
psychotherapeutic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
levomilnacipran 5.3 109 reviews for levomilnacipran to treat Major Depressive Disorder Rx C N X
Generic name:
levomilnacipran systemic
Brand name:
Fetzima
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
selegiline 6.5 17 reviews for selegiline to treat Major Depressive Disorder Rx C N X
Generic name:
selegiline systemic
Brand name:
Emsam
Drug class:
monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Exxua Rate Add review Rx N
Generic name:
gepirone systemic
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
gepirone Rate Add review Rx N
Generic name:
gepirone systemic
Brand name:
Exxua
Drug class:
miscellaneous antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph

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Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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