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User Reviews for Prozac to treat Major Depressive Disorder

Prozac has an average rating of 6.3 out of 10 from a total of 74 ratings for the treatment of Major Depressive Disorder. 54% of those users who reviewed Prozac reported a positive effect, while 31% reported a negative effect.

Prozac Rating Summary

6.3/10 average rating

74 ratings from 79 user reviews.

Compare all 54 medications used in the treatment of Major Depressive Disorder.

10
24%
9
18%
8
12%
7
4%
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3%
5
7%
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1%
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7%
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5%
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19%

Reviews for Prozac

Cj1994 May 14, 2021

“I have SAD, GAD, PTSD, and major depressive disorder in a bipolar spectrum. I suffered from random depressive episodes, PMDD, irritability, crying randomly, suicidal thoughts, social isolation, insomnia, etc. I was on 100mg of zoloft once and it did absolutely nothing to me, so I became discouraged from taking meds for 8 years as I felt hopeless. However, during 2020 my depression got so crippling. I reached out and was prescribed this medication. The first week or two, I was really depressed. However, I've been on it for 3 months now and have not had a single random depressive episode. In addition, I no longer experience PMS. I do have side effects: worsened hand tremors, constipation, and a hard time orgasming. Despite these, it is still very worth it to me after going through what I did. I know you're reading these reviews and it is scary and you feel hopeless, but I want you to know that you should give it a go.”

9 / 10
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Meech · Taken for 6 months to 1 year April 18, 2021

“This has been a roller coaster of a year and I’m glad I’m going to stop taking Prozac for multiple reason. Prozac helped with my mood, but I still have bad days. The major reasons are fatigue/low energy, anti-social, and irritability. I can’t believe I’ve been taking it for a year because it has caused major problems in my life. Obviously it works or it doesn’t. This medication was a nightmare for me.”

3 / 10
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t1mmychalamet · Taken for 1 to 6 months April 14, 2021

“Took prozac for MDD, OCD, & anxiety for a few months at about 20 mg (so maybe that’s why I didn’t really notice that much of a difference haha) but the upside is that I didn’t notice any cons either”

6 / 10
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Shireen2020 · Taken for 1 to 6 months April 5, 2020

“It’s the first time ever I am leaving a review for something because i thought i owe that to myself and lots of people who are uncertain or hopeless, I took Paxil before Prozac for about 4 months, no effects at all, i asked my doc to prescribe Prozac because I was getting worst, was so depressed, always in a sad mood, was crying a lot, did not have the power to do anything at home, spent hours on bed at the weekends... And then started Prozac , after 3 weeks I had some up and downs, I was giving up till I started feeling better after 4-5 weeks NOW i am taking it for 5 months, did not cry for a long time, no sadness, no depressed mood, no anxiety..I am just so glad i did not give up, I am a mom and i needed to get up again. After years I feel I am living... thank to Prozac”

10 / 10
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MyDogIsAwesome July 18, 2019

“I have suffered from MDD for 4 years before I got my diagnosis. By the time of my diagnosis, I had mental breakdowns every night, was completely withdrawn from all friends and family, and my grades went from straight A’s to straight D’s. I was tired, numb, and sick. I tried to kill myself twice. Then I started Prozac at 10mg and then up to 40 mg. Three years later, I was finally able to get my life back together. It takes several months for Prozac to take effect. For me, it was an entire year. For sure it’s no miracle cure, but I was less empty and less tired. Prozac is not a happy pill. It won’t fix your problems. It won’t make life seem infinitely better. It won’t undo the damage. Nothing will. It will only give you the opportunity to make everything better again. And for me, that was opening up to others and seeking the help I needed. I'm doing better now. Prozac did it’s job. Now I have to do mine.”

9 / 10
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Parker · Taken for less than 1 month September 23, 2020

“I’ve been suffering from severe depression and anxiety since three months now , mainly because of past traumatic experience and my Hashimotos disease condition caused by excessive stress. Even thought I’ve been on levothyroxine it doesn't help me with dealing with depression. My psychiatrist put me on 20mg and asked me to double the dose of there isn’t any effect in another 2 weeks , but this medication worked wonders with deceasing depression and anxiety and has uplifted my mood and spirits with life. I didn’t need the need to increase the dosage yet. I’ve read a lot of side effects, but apart from less sleep I have not witnessed any other side effect. I sleep better now as k take the medication everyday at morning 10 am .”

9 / 10
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tatiana757 · Taken for 1 to 6 months April 25, 2014

“Prozac saved me! I've been in and out of hospitals for 10 years. Was diagnosed with Major Depressive Disorder. After changing Doctors and medicines I finally feel like myself again. I here no voices of worry and stress. I'm not irritated over the slightest things. I can now think clearer. After months of depression and panic attracts my new doctor recommended Prozac. For weeks I felt nausea and weakness. Then on the third week I got up and out and got a job the same day! I was no longer stuttering and confused. My relationship with my significant other is 100% better. My thoughts were very clear. I'd finally gained my confidence back! I'm very happy I tried Prozac. I feel amazing.”

10 / 10
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Ben · Taken for less than 1 month May 31, 2019

“I've always been a fidgety person along with anxiety and pretty bad mood swings. It got to the point where I have no friends, I've pushed away family and lost relationships. Today was day 1 of prozac and I just cant believe how fast it started working. For once in my life I feel normal! I'm happy, I can catch my breath and I can't wait for tomorrow. This drug very well may have saved my life and I'm so grateful I finally found something that works!”

10 / 10
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JaneDoe · Taken for 1 to 6 months June 4, 2020

“Prozac is the best anti-depressant I’ve been on. It worked really well for 6 months and then it started to stop working (I wasn’t very consistent in taking my pills). I had very little side effects. The first month of being on it is very nice. It lets you feel happiness after not being able to. I’ve been off it since August and have not felt the need to start any meds again until recently. Prozac helped me be able to gain that sort of control. It’s okay to depend on medications for awhile or for a lifetime, whatever works for you.”

7 / 10
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Auma13 January 15, 2016

“I've been using 40 mg of prozac daily for almost a year now, I went from the worst I've ever been, crying all the time never being able to stop thinking about how much I hated myself life and everything about life, I was not eating, was so full of rage and hate and had the most negative mindset towards everything, like every second of my life was hell and pointless seeming, I wished I was dead (although would never actually kill myself for my families sake) and after about 2 or 3 weeks of taking the prozac everything got so much better it was like it flipped a switch in my head and the negative thoughts went away and I actually felt good and happy which I thought was so impossible to feel, taking these meds was the best thing I've ever done”

10 / 10
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Awful drug · Taken for 6 months to 1 year July 29, 2020

“((My experience with Prozac, other people will have different experiences))At the start you feel great then after a month or so onwards no improvement. It's only a mood stabiliser to stop 'bad thoughts' no low moments, no high moments. Just walking through life like a zombie. Doubled my dose and for a week I felt productive then my tolerance caught up. Quitting was the best decision I made. I feel happier and my 'brain fog' is clearing. It's good for anxiety though as it numbs you completely:D”

4 / 10
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Penny · Taken for 2 to 5 years October 27, 2020

“I have been taking Prozac now for 4 years. I started out on 20 mg. After a few months, the doctor upped it to 40 mg. A few days ago, the Prozac was upped to 60 mg. Since being on the 60 mg, I have been feeling slightly nauseated. I'm hoping it will subside soon. Not sure why I never had difficulties on the 40 or 20 mg. Did I gain weight? Yes, but it was pretty much my fault as I ate all the wrong foods and never moved around much. I changed to whole foods, ditched the sugars and carbs and have lost 40 pounds from July until now. I see people say don't take Prozac. My thoughts are that their experiences are not my experiences. Before the Prozac and Sertraline, I had very bad mood swings and lashed out at people. I also have major depression as well as PTSD. The Prozac has been keeping me from lashing out to others. I would much rather keep myself calmer than to attack others.”

7 / 10
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Rachel- March 3, 2015

“Suffered with depression since early teens, but hit rock bottom when a friend committed suicide, I could no longer work, couldn't eat, had panic attacks and became suicidal. After 3-4 weeks of taking Prozac I began feeling like a normal person and after 6 weeks I felt happier than I could ever remember being for years. Prozac has saved me, will happily stay on it for life if this is how it makes me feel.”

10 / 10
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Lisee · Taken for 5 to 10 years January 4, 2021

“If you are looking to COMPLETELY numb yourself out then this is the medication for you. But if you still want to feel your emotions and feel happy about things and a little sad about others, I DO NOT suggest this. It only numbed me.”

5 / 10
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Al Pac · Taken for 2 to 5 years April 10, 2016

“This medication is a life saver. I think Prozac has saved my life and made my thinking more clear. I had been struggling with mental illness for years before I tried prozac. I had been diagnosed with adhd and bipolar disorder (even though I never had a manic episode). I had tried other medications. After a suicide attempt, I tried zoloft, however, there was no effect. After this ssri, I tried other medications and everything made me unbelievably worse. After trying medications like lithium, lamictal, depakote, and abilify; I finally was put on 10 mg prozac and then 20 mg. This was it. I felt an instant recovery after 3 weeks, where my mind finally woke up. I felt a part of my brain, which was not working, was now working. It was lifesaving.”

10 / 10
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eisheth666 · Taken for 2 to 5 years February 19, 2020

“While it did help my depression, it made me gain 30 lbs & made me a walking zombie. I was unable to feel emotion, just a numb feeling. My husband commented after I stopped taking it how much easier it was to talk to me. He said while I was on it I would look at him with a blank stare while he was talking & not really reply or just ignore him altogether. I was in my own little world on this stuff. Libido suffered immensely as well.”

1 / 10
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Jorts Borby · Taken for 1 to 2 years April 2, 2019

“I tried so many drugs for so long, but nothing worked as well as Prozac has. I spent month struggling to get out of my house on other drugs, but with Prozac I can go out again. It seems almost unreal! I’m so grateful for this medication and I hope someone else can get this help too!”

10 / 10
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kd3h · Taken for 1 to 6 months November 18, 2014

“I've been on every antidepressant known to mankind and they were awful to me. Either the side effects were too bad or it turned me into a complete zombie to the point work was out of the question, and then my dr said we would try one more called Prozac and the reason he had not prescribed it before was because it took 6-8 weeks to reach full effect as where the others took less then half that time. I started out taking 10mg because I have always been very sensitive to antidepressants and their side effects. For about the first 2 or 3 weeks I experience light anxiety... Then finally the 6 weeks passed and still nothing, but then finally about 8 weeks into the mediation, I feel like Santa Clause on steroids! It has saved my life! ”

10 / 10
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jonathon1990 November 1, 2014

“I treated my major depression with any type of narcotics or benzos. I was so depressed just wanted to die. But I found Prozac. Now loving life clean sober and happy. Please try this medication. 40 mg 1xday. Free at local health department”

10 / 10
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bigmama · Taken for 10 years or more May 10, 2019

“I started on Prozac in '05, and has been on it ever since. I'm not sure to say it was for major depressive disorder, but I was just waking up and seeing the world in a way with no feeling. I had depression when I was young, and continued. Prozac has been up and downed in the dose. But I currently take 80 mg, and I have to say it helps with feeling better, wellbutrin was more stimulating but much anxiety, other serotonin antidepressants somewhat worked, but Prozac is the one I keep using because it worked. Prozac just simply help my mood, I could be in the mood to talk. When it's not taken or if I miss one or 2 days, I can tell, mentally sluggish, the depression of not feeling anything. Prozac makes me less apathetic, and I'm in a better mood. Some people have an opposite reaction, and have flat feeling. I have bad days, many ... but it keeps from falling into major depression.”

9 / 10
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Shellsheree August 14, 2016

“I feel fantastic I feel a massive change in myself I'm less aggressive anxious depressed and agitated I'm more patient with things and people as I suffered with social anxiety I'm more outgoing and thinking clearer I feel on top of the world and have lost 13kg as my appetite has decreased rapidly”

10 / 10
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sunflowersareyourbestfriend November 23, 2015

“I have Major Depressive Disorder, Bipolar Disorder, and anxiety, I have never felt more calm and in-control of my emotions. Usually every night I'd fall into a fit of thinking of self-harm, I have thought of them no more, I still get sad, but it's sadness, not full on depression. My anxiety has decreased so much, I still get nervous, but it is not even close to how bad it was. An added bonus, is for me, it makes me drowsy, so I get more sleep. I have never been so happy in my life. Prozac is a life saver.”

10 / 10
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calla92 April 16, 2016

“Following the death of my 3 year old daughter I started taking this also Valdoxan at night and anti calm during the day I also suffer from anxiety , Prozac has helped me get up in the day time and go out and changed my attitude also obviously it's false happiness but it helps me forget my pain and have a giggle during the day it eases my pain”

8 / 10
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depressedgirl1 · Taken for 1 to 6 months May 17, 2018

“I have been taking Prozac 20 mg now for at least a month and a half and I am so glad for this medication. On the first day I took this pill I felt different. I have lost weight which is a great thing because I am overweight. I don't really have a appetite, not complaining about that at all but the only down side is NOOOOOO sex drive at all and I can barely have a orgasm. I'm going to stick with the medicine because I have struggled with depression for years and years and haven't felt this good in I don't know when. My medicine works all day everyday and sex only last a few minutes...not giving up my medicine for sex. Give the medicine time to get in your system it really works and it has saved my life! Thank goodness for this Pill.”

9 / 10
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Rachelling September 5, 2018

“My mental illnesses that started when I was 13 & I had my first attempted suicide and ended up in a long term hospital for treatment. I was given Prozac when it was “The In” drug for teens! Now at 41 I’ve been on everything & now I’m back to Prozac. I feel amazing when I’m on it! I usually start feeling normal & stop taking it thinking it was a phase until it comes back! Now I’m sitting at my pharmacy waiting for it when normally with any antidepressants I couldn't care a less when it gets filled cause I still have to wait a month for it to work! Prozac seems to work instantly! It gave me energy, made me focused and happy! No dark, paranoid thoughts! Sex drive decreases but I can still orgasam. Everybody’s bodies are different and we all have different disorders, to me Wellbutrin was THE WORST! I think you have to trust your doctors and try a few and go with the one that works the best with least side affects!”

10 / 10
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Badkittym · Taken for 1 to 6 months May 12, 2017

“After years on duloxetine for major depression and degenerative osteoarthritis, a new psyche doctor had me try Effexor (terrifying effects). Bad trip. He had been having me take Prozac while I was weaning off duloxetine because it mitigates the withdrawal syndrome from duloxetine, and I felt better than I had in 10 years. After the near-suicide because of Effexor, I asked if we could just stick with Prozac but increase the dose. I prefer it because I feel like ME, not some drugged-out, flattened-emotion version of me. I still can get happy, sad, mad, chill, relaxed, etc. Many anti-depressants eliminate that ability, which I find unbearable personally. I take 20mg once per day in the morning, and it has given me my life back again.”

9 / 10
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Jackleine · Taken for 1 to 6 months May 19, 2015

“I've been on Prozac 20mg since almost 2 months, for having severe depression and suicidal thoughts and death scenarios, I just want to say that this medicine is a life savior, it works miracles, regardless the fact of having so much dizziness (especially when working out), but thoughts get more positive by time.”

9 / 10
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Taximan42 · Taken for 10 years or more November 20, 2015

“I have been on this medication for around 12 years 60mg a day for OCD and depression, it got me out of a very very deep hole, got me back to work able to function got me back as a normal person, u fortuantly i used alcohol and recreational drugs aswell which made me riddled with anxiety and depression, im clean and sober 8years now and am still on the prozac, iv recently had a low episode and i was self medicating with my prozac as and when i needed, obviously this wasnt the greatest ideas and this has led me back to being depressed again but im back on 40mg of prozac a day, i may feel like i have gone back to the begining of it all but i havent iv just had a little set back in my recovery, all in all prozac for me is a life saver”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Major Depressive Disorder

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Symptoms and treatments