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Prozac vs Zoloft - What are the Differences & Similarities?

Medically reviewed by Carmen Pope, BPharm. Last updated on July 22, 2024.

Official Answer by Drugs.com

Both Prozac and Zoloft belong to the class of medicines called selective serotonin reuptake inhibitors (SSRIs) and are FDA approved to treat depression, OCD (obsessive-compulsive disorder), and panic disorder.

The main differences between Prozac and Zoloft are:

Because both drugs are SSRIs, they have many similarities, such as:

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References
  1. Kroenke K, West SL, Swindle R, et al. Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial. JAMA. 2001 Dec 19;286(23):2947-55.

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How long for an increased dose of Zoloft to work?

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Does Benadryl help with or cause anxiety?

One of the most common side effects with Benadryl is drowsiness, but in some people it can have the opposite effect, known as paradoxical excitation. Instead of feeling sleepy,
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Is Zoloft (sertraline) a controlled substance?

No, Zoloft (sertraline) is not a controlled substance. It is in an antidepressant drug class known as selective serotonin reuptake inhibitors (SSRIs). Zoloft is commonly used to treat depression, anxiety, panic attacks and other mood disorders. Doses should be stopped slowly to help prevent withdrawal symptoms. Zoloft can be used for long-term treatment if needed. Continue reading

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