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User Reviews for Depakote

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

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Condition Avg. Ratings Reviews Compare
Mania
7.7
   
14 reviews 15 medications
Epilepsy
6.9
   
37 reviews 41 medications
Bipolar Disorder
6.2
   
127 reviews 30 medications
Migraine Prevention
5.5
   
33 reviews 29 medications
Not Listed / Other
6.1
   
4 reviews
Summary of Depakote reviews 6.3 215 reviews

Reviews for Depakote

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For Bipolar Disorder "I'm bipolar ll. Recently started Depakote. Started out at 200 mg, now at 800 mg. So far so good. Will write another review in another month or two. I was terrified starting this medicine, but it has been great so far. I'm still not at my target dose, but it has already helped racing thoughts, depression and hypomania. I feel more hopeful, a lot calmer and less stressed out. NO WEIGHT GAIN AT ALL. Not even a single pound. I've actually lost weight. Side effects? The first week I felt more depressed, but it didn't last. Tiredness, nausea and a bit foggy after each increase. Easy peasy. I have tried 15 medicines including Lamotrigine, Trileptal, Abilify, Gabepentin and countless antidepressants. Nothing worked. Fingers crossed. Big hugs to all of you bipolars out there!"

   
8.0

CyclingSarah (taken for 1 to 6 months) April 7, 2018

5 users found this comment helpful.
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For Migraine Prevention "I have a migraine 4 to 6 times per week. I have tried Maxalt, OTC drugs such as Acetaminophen, Excedrin, Advil, PM meds like Advil PM, amitriptyline, and now Depakote. Depakote has done nothing at all to improve my migraines. At this point, I wonder if anything is going to ever help my migraines. All of the meds I mentioned above do not help. I'm at my wit's end. I tried Topamax too a few years ago and it made me so nauseous and didn't help my migraines. I had an MRI done, and the ENT doctor said there were no brain abnormalities seen on the MRI disc. I don't want to be a guinea pig ( hey, try this), or a medical mystery. All I want is some pain relief. Caffeine doesn't help, nor does alcohol. Does anyone have any advice? Thanks!"

   
1.0

simkitkat66 (taken for 1 to 2 years) April 1, 2018

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For Bipolar Disorder "Love it. 15+ years taking it"

   
10

Tricia (taken for 10 years or more) March 28, 2018

4 users found this comment helpful.
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For Bipolar Disorder "Rubbish med. Ruins liver"

   
1.0

alschuster March 22, 2018

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For Bipolar Disorder "This review is on behalf of my 16 year old son. Manic Ups and downs for years, between over the top excitement/happiness (rare and short lived) or anger/violence or full depression /sadness. Just trying to help him level out. Has been moved on and off many different medications to try to find a fit. Most recently Dr added depakote to his 900 mg lithium & 15 mg abilify. First four days started with depakote 500 mg; then added another pill to 1000 mg. Started to have digestive issues and tremors but pulled through. Increased to 1500 mg 4 days later which led to more tremors and violent vomitting. Dr suggested splitting the doses am/pm. Within 2 hours of taking the am dose the next day- same violent vomitting. Confirmed no stomach bug. His body was unable to handle the level of Depakote. Now, No longer taking. I've read many positive reviews on this medication , but sadly ours is not one of them due to his adverse reactions."

   
1.0

Still Looking for Answers March 19, 2018

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For Migraine Prevention "Lethargy, weight gain, depression, headaches, muscle aches, nausea"

   
1.0

Dee (taken for 6 months to 1 year) March 12, 2018

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For Bipolar Disorder "I was diagnosed with depression and anxiety 35 years ago, but finally received a diagnosis on the bipolar spectrum two years ago at the age of 60. Depakote ER (2000mg at night) fixed things I didn't know were wrong and has stilled the ultradian cycling that was really my problem all along. I feel luck that the only side effects I have encountered are hair loss at first (now resolved) and occasional heartburn. It relieved most of my depressive and hypomanic symptoms within three weeks, but I just added Lamictal to help a little more with depressive symptoms. I take a complicated stack of meds to manage psych. symptoms, but Depakote is by far the most important."

   
10

sf100 (taken for 2 to 5 years) February 7, 2018

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For Bipolar Disorder "I have been diagnosed as bipolar for 20 years now and just a month ago listed as bipolar 1 severe with mixed moods. This is the only medication that REALLY works to help control my manic moods. ONLY side effect for me is a little bit of shaky hands after taking for a few hours."

   
8.0

Ash11485 January 26, 2018

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For Bipolar Disorder "I have been taking depakote @ 1000mg for the past year and a half. I also take risperdol @ 1mg and just added on zoloft @ 100mg as well. The only positive thing this medicine has done for me is rid me of mania. I am constantly depressed and have persistent suicidal/negative thoughts. I feel like I have been sleep walking through my life since I have been put on this medication. Also I have gained 50 pounds and am so hungry all the time. I also have zero libido. When I say zero I mean zero. I have had sex on this medication and it was the most unenjoyable experience ever. Just nothing. Next time I go to see my physiatrist I am going to ask to switch medications. This might work for some but it has not worked for me in the slightest."

   
1.0

teelar (taken for 1 to 2 years) January 20, 2018

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For Bipolar Disorder "Start a few days ago this medicine. So far I'm ok, no side effect. I can sleep all night and wake up rested. All my body pain is almost gone. Calmed my mania and anxiety. Been on Lithium before but was awful with the side effect and the worry to hurt my kidneys. Hoping this medicine works for me."

   
9.0

Liz2018 (taken for less than 1 month) January 19, 2018

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For Bipolar Disorder "I've taken depakote for 13 years along with citalapram. 250 mg depakote with 10 mg of citalapram. It helped with my intense excitability, my severe depression and suicidal thoughts which happened to me 2 weeks out of the month. It was so bad. After taking these meds I felt so much better like a "normal" person. I had no side effects. My symptoms were down to 3 days instead of 3 weeks which I could deal with and didn't want to kill myself anymore. I'm an bipolar and/or pmdd. They are not working for me anymore so I'm going to have to change to something else. Hope this helps someone. :)"

   
10

Yellehs (taken for 10 years or more) January 7, 2018

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For Bipolar Disorder "Hi I've recently got married to my partner of 6 yrs, last year he was diagnosed with bipolar he has tried all different kinds of medicine but he’s started a new one call Depakote 5-10-17 for the last 2 weeks he’s had 2 personalities Mr Nice and Mr Horrible it can changed within mins do you think I should contact his doctor or bear with it. He’s never been like this I can’t talk to him, I can’t even look at him without him asking me what my problem is. This is really out of character. He is normal downer I know when they are coming and I can take time out and after 3-4 he’s back to him normal happy self but this I not sure how much more I can cope with!! We have a 5 yr old who keeps saying will daddy get better! I’m just in desperate need for some."

Life15hard (taken for less than 1 month) October 14, 2017

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For Bipolar Disorder "It made my bi polar disorder worse, I had bad ringing in my ears also my heart rate increased. But it wasn't worse then when my hallucinations got so much worse then they already are."

   
9.0

Babi Girl95 October 2, 2017

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For Bipolar Disorder "Love this medication, after 2-3 years of severe long lasting manic episodes finally decided to take meds full time. Hardly any side effects, very hungry, simply eat normally and you wont put weight on, the medication doesn't make you fat, eating does. Occasionally very tired and my stomach from time to time gets a little funny, just take with lots of water and food. Very calm, can concentrate, no racing thoughts, level, basically gave me my life back, works well at 750 even though I'm 80kgs, Dr upped me to 1000mg but felt too sedated so dropped back down. I move to 1000mg if I feel like I'm starting to drift a little for a few weeks then move back. However, this is the 7th med I have tried, all others have failed, never write one med off"

   
9.0

qwertyazsxdc (taken for 5 to 10 years) August 26, 2017

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For Epilepsy "I used to have a wonderful smart son. About 12 years ago, I noticed changes starting to take affect in his life. He was becoming agitated, he was loosing his memory, he had no energy. I was told this was due to his having so many seizures. I just this week, after having a really bad week a few weeks ago, the doctor decided to take him off of this medication in a hospital controlled setting. After one day of not taking this medication, I am starting to see the personality of my son come back. He had gotten to the point that he made terrible decisions, he was depressed often, he was confused and was loosing his memory and his ability to talk and remember words. I'm sorry, but the benefits of controlling seizures was not worth this."

   
2.0

J A J July 24, 2017

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For Migraine Prevention "Horrible! I was on it for a month, and quit immediately. I have migraine with aura. My neurologist told me a secret behind closed doors cause he was a cool dude. He said get off all the crap and once the aura comes chug two beers and it will disappear no aura no headache. He swore by it and so do I."

   
1.0

Craigsugarhill (taken for 1 to 6 months) July 14, 2017

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For Epilepsy "Have taken this med for 28+ years with no seizures during this time. I have experienced no side effects except that my hair has become very curly. Lots of compliments! No down side. I am seizure free. No other med has worked for me."

   
10

Heroncrest July 14, 2017

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For Migraine Prevention "If you want to sleep a lot, as in all day long and gain lots of weight, enjoy. I am listless, and have pre-diabetes now. "

   
3.0

depabie (taken for 1 to 2 years) May 6, 2017

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For Bipolar Disorder "Best med I've been on for Bipolar I. After 10 years on Lamictal as monotherapy, with continued mania and depression. I was hospitalized and switched to Depakote. I'm sad my doctors didn't try getting rid of the Lamictal sooner. I take 500mg (delayed-release) twice a day and, along with 80mg of Latuda, I haven't felt this stable or anxiety-free since I can remember. I'm not dulled out, back to my normal, serene self. Depakote is known to work wonders for mania, and I can attest to this effect being noticeable right away. I have gained a few pounds but I'm too happy with how calm, collected, and lucid I feel to think about letting Depakote go. No other side effects, and I don't find it highly sedating -- guess I'm one of the lucky ones."

   
10

FuckLamictal (taken for 1 to 6 months) April 15, 2017

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For Migraine Prevention "I meet with a neurologist for my migraines. He put me on depakote at bedtime. I've been on it almost 6 months now and I am starting to have them as frequent as I used to...3 times a week. I also take Keppra and duloxetine every morning. I've been struggling for almost 20 years now. I just can't get rid of one all the way. Any hospital visit that I go to, they give me benadryl and tramadol, even when I tell them it doesn't work for me. I've only gone to the hospital about 6 times in my life for them."

   
2.0

dLynR_88 (taken for 1 to 6 months) March 26, 2017

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For Bipolar Disorder "Depakote was a nightmare. Besides having acute, non-stop stomach pain with chronic diahrrea, my hair started falling out in clumps. Good thing I have thick hair or I could have been bald at the end of this drug. I don't recommend this to anyone. It was like taking poison."

   
1.0

Velveteen Rabbit (taken for 1 to 6 months) March 1, 2017

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For Migraine Prevention "Depakote was started three months ago when we exhausted all efforts with every other preventive med for migraines and headaches . I have been Experiencing these my entire life. Since 6 years old . Now 35., imitrex was used to try to knock off the migraine but insurance only provides nine pills a month so I found myself breaking them just to get through a day .And if over used they will no longer work. So I'm adding in aspirin all that junk. Ending up in ER. Just to go back the next two days because the stubborn migraine would come back , or laying in bed holding my head with ice. needless to say , on a small dose 250 a day . Wow few headaches a week I can deal with. Weight gain well now I can workout no real excuse there."

   
8.0

Ljtb123 March 1, 2017

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For Migraine Prevention "50 Year old male, 6'5" 210 lbs, I have had migraines for ten plus years. I am on 100mgs of Topamax twice a day which gave me four to five migraine a month. Doctor put me on 250mgs Depakote and so far I am down to one migraine a month with no side effects from the Depakote - that I can tell. I call that a win!"

   
9.0

VADiesel February 22, 2017

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For Bipolar Disorder "I have been through so many medications it's ridiculous... most of them didn't work AND caused severe side effects. The last one I was on before Depakote was lamotrigine (which really is better for bipolar II, from what I understand). I tend to run very manic (and don't have a thyroid anymore - cancer), so my doc and I decided this would probably be my best option. None of the new drugs worked on me. Depakote has been amazing. I can think a lot more clearly and I'm still me - just a lot more toned down. I've had no negative side effects except a slight tremor, but I'm also on xanax for severe anxiety, so its only noticeable when it's time for that. No weight gain, either. In fact, my appetite decreased. I haven't gained or lost, really."

   
10

espresso_dreams (taken for 1 to 2 years) December 27, 2016

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For Bipolar Disorder "Didn't realize how great it was till it was gone. After 4 years of failed cocktails until I found Depekote with Zoloft. I was on it for 3-5 months @1250mg and had Excessive Weight gain, insatiable hunger,,,BUT Worth it! I was productive, positive, stabilzed, making plans and following thru. Then Liver enzymes high @ 6 mo. and abruptly taken off ... Horrible move by panicked Doctor. On my third medicine since and all bad results. Any opinions on Depokote retry while protecting my liver with Milk Thistle & Turmeric? My last blood work was best its ever been. I have no faith in my Dr and am seeking a new."

   
8.0

Karyn 44ys Single Female (taken for 1 to 6 months) December 9, 2016

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