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Depakote for Epilepsy User Reviews

Depakote has an average rating of 6.4 out of 10 from a total of 55 reviews for the treatment of Epilepsy. 49% of reviewers reported a positive experience, while 25% reported a negative experience.

Depakote rating summary

6.4/10 average rating

55 ratings from 59 user reviews.

Compare all 228 medications used in the treatment of Epilepsy.

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Reviews for Depakote

  • Philrx
  • Taken for 10 years or more
  • August 13, 2019

"I have been taking 1 Depakote 500mg ER brand tablet daily for 28 years (I am 40). Used to treat Juvenile Myoclonic Epilepsy. This medication has been a tremendous blessing for me as it has controlled my seizures for the last 26 years. I’ve had no side effects but I will mention that I was very active as a child playing sports and continued to spend many hours a week lifting and exercising all through HS and college. I continue to exercise at least 3 days a week. I mention my exercise habits for a reason. I have noticed that during the times when we had our children and I wasn’t getting good sleep and not able to exercise as much, I began to notice some possible side effects related to the medication (slight tremors, lethargy, difficulty remembering names). When I started back exercising, all the side effects went away. I am a practicing pharmacist and married with 2 healthy children. I realize that my story may be somewhat unique, but I decided to share to give another long-term patient experience."

10 / 10
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141 Report
  • J A J
  • July 24, 2017

"I used to have a wonderful smart son. About 12 years ago, I noticed changes starting to take affect in his life. He was becoming agitated, he was loosing his memory, he had no energy. I was told this was due to his having so many seizures. I just this week, after having a really bad week a few weeks ago, the doctor decided to take him off of this medication in a hospital controlled setting. After one day of not taking this medication, I am starting to see the personality of my son come back. He had gotten to the point that he made terrible decisions, he was depressed often, he was confused and was loosing his memory and his ability to talk and remember words. I'm sorry, but the benefits of controlling seizures was not worth this."

2 / 10
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35 Report
  • Build...
  • August 26, 2014

"Started with Depakote upon being diagnosed with Juvenile Myoclonic Epilepsy in my teens. I took it for years without issue. I decided to switch to Keppra XR because of potential liver issues with Depakote and the somewhat tiresome redundancy of labwork related to Depakote use. Keppra XR did not work for me as my memory began growing progressively worse and I could not think clearly. I also began losing my train of thought mid sentence fairly often. Switched back to Depakote ER, and am feeling much better mentally. The quarterly labwork is not a big deal when compared to being in a mind fog for over a year. That's my experience, hope everyone finds what's right for them. P.S. I do not take generics, noticeably more side effects."

10 / 10
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45 Report
  • Anonymous
  • Taken for 1 to 6 months
  • February 28, 2016

"This medicine took 3 weeks to fully kick in. I had the side effect of increased appetite, but I haven't gained any weight because I eat a low carb diet and workout 4 times a week. I do not have any side effects anymore and this mostly controls my temporal lobe epilepsy."

10 / 10
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39 Report
  • Heron...
  • July 14, 2017

"Have taken this med for 28+ years with no seizures during this time. I have experienced no side effects except that my hair has become very curly. Lots of compliments! No down side. I am seizure free. No other med has worked for me."

10 / 10
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33 Report

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  • Nick
  • Taken for 10 years or more
  • September 30, 2015

"Before I came to the US I was taking other medications for epilepsy but upon dealing with a US doctor he recommended 2000 mg of Depakote daily. I immediately went to the library and checked the side effects, which were considerable. I asked the doctor if I could take a smaller dose but he didn't think it wise. I decided to take matters into my own hands and reduce my dosage. I have been taking 250 mg now for 35 years with no seizures. Early on I found that when I took long flights to Asia and missed sleep and became dehydrated I would increase my dosage and then when I came back home I would slowly lower it again. I don't believe I am suffering from any side effects of this drug."

10 / 10
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38 Report
  • Wildr...
  • Taken for 5 to 10 years
  • January 4, 2016

"I currently take Zonegran --I love love love it!!!--- Prior to this I took Depakote--for me this drug sucked-- I was lethargic, my hair fell out in clumps I went from weighing 225lbs to 389lbs and I developed Sleep apnea. I was taking 500 mg of Depakote four times per day---2000mg of this stuff-- I had several seizures in my sleep one where I fractured my ankle on the bed frame. The weight was the worst I could not control it. I wish I could submit a picture of myself while being on this stuff. After I got off this drug I lost 160lbs. My dad saw the b4 pic and didn't know who I was. Maybe this works for some, but not for me I would never take this again!!!"

1 / 10
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32 Report
  • linse...
  • March 14, 2014

"Taking Depakote for grand mal seizures since I was 12. I'm 28 it has always worked unless I don't take it. It thinned out my hair, made me gain 15 lbs and makes me really tired. I take 1000 mg a day. It is very toxic for your liver, you really should not drink on it! Working out helps with battling the tiredness. Hoping to switch to Lamictal again. I hate the side effects but it works great for grand mal seizures!"

7 / 10
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35 Report
  • Happy...
  • Taken for 2 to 5 years
  • March 4, 2015

"I'm 24 years old and I've been epileptic for about 12 years. I've seen my fair share of doctors and I was either too medicated or ignored, so remember, the doctor isn't always right. I recently found my current doctor about 3 years ago and she has gone above and beyond for me. I am currently seizure free and can drive. I currently take 1000mg Depakote ER a day 200 mg of Topamax a day to balance out the weight gain. I do have a slight problem with my hair, it won't grow, but that's okay."

10 / 10
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31 Report
  • TLN
  • Taken for 5 to 10 years
  • September 10, 2020

"This drug Depakote gave me side effects I gained 50 lbs, hair fell out and tremors. Was put on it for migraines initially but after 2 years migraines turned into seizures. I question if the drug didn't cause my seizures."

1 / 10
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15 Report
  • jeckac
  • April 6, 2009

"My 6 year old son has been on this medicine for 3 1/2 years. He has had some side effects such as overeating. He craves corn and strawberries like you wouldn't believe. He eats can after can of corn and crates of strawberries. At least it's healthy food, he isn't overweight. He also started having symptoms of ADHD and Autism (behavior problems). Most ADHD medication does not go with Depakote. We got the seizures under control only to have other problems. Also, you should ask your doctor to do blood checks every 3 months to rule out any other complications from this medicine."

8 / 10
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37 Report
  • Katie...
  • October 15, 2015

"Be careful. My experience put me in the emergency room BUT my friend takes it and has had a fantastic experience. every person can have a different reaction, know the risks and definitely do a lot of research."

6 / 10
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24 Report
  • hekhek
  • Taken for 10 years or more
  • February 15, 2014

"I was put on Depakote when I was 17 when I started to have seizures due to head trauma from a motorcycle accident. Initially my dose was higher I don't remember exactly how high but then I was lowered to Depakote ER 500mg once a day. As long as I took my medicine and didn't drink as much as before and got regular sleep I did not have any seizures. When I've ran out of the medication and went out and drank (like an idiot) I had a seizure the next day. This happened to me like 3 times but it's my own fault. Anyway as long as I take it daily and control any other factors that could cause a seizure I'm seizure free. I've never had a seizure while taking this. First side effects were slight hair loss which stopped. But I did gain weight."

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26 Report
  • topaz
  • Taken for less than 1 month
  • February 22, 2022

"This is the worst drug I have ever taken. I started off with double vision, muscle weakness and unstability so I could not walk, and dizziness. I fell and broke three ribs. I had hallucinations, aggressive behavior, anxiety, mood changes and paranoia. I was in the hospital when all this happened and they kept giving it to me. I tried to escape the hospital and the goon squad stopped me. One night I was convinced I was going to be kidnapped. I had to go to rehab to learn how to walk with a walker. The rehab doctor cut the dosage and my mental health improved. They kept giving me opiates for my back pain. I also had other side effects such as back pain, runny nose, difficulty sleeping and constipation. When I finally got home I quit taking this stuff. In about four weeks I was back to normal."

1 / 10
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8 Report
  • SFL
  • June 10, 2011

"I have used Depakote for the past 13 years now, 500 mg per day. The only side effects were nausea and anxiety for the first day or two. At that point, I was taking 1000 mg. My neurologist pulled back the dosage to 750 mg and later 500 mg. I've never had weight gain as a result of it and notice no ill effects with light drinking. I did stop taking Depakote for about 6 months about 10 years ago and soon thereafter had a petit mal seizure. I immediately went back on Depakote and haven't had an issue since. Really couldn't be more satisfied with this medicine."

10 / 10
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29 Report
  • katie...
  • Taken for less than 1 month
  • September 22, 2019

"I was on depakote when i was 16 or 17 for my epilepsy it was effective for my seizures but I started having hideous dark thoughts and was worreid about my own safety this was 2 weeks after starting depakote it really freaked me out. I told my parents and my doctors and they took me off of depakote as soon as it was out of my system these thoughts went away""

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13 Report
  • perky
  • Taken for 10 years or more
  • June 13, 2015

"I gave this drug a 4 because of what it did to me, and what they didn't mention at the time, also because what it did to a friend of mines daughter, as far as a seizure drug and mood stabilizer a perfect drug. controls most seizure in people. But I was on this drug for over 10 years . No one said it could affect my bone density at the time. At 29 I got diagnosed with osteoporosis. I am not happy. I have multiple back issues now and spinal fractures. They did not heal correctly and I am in constant pain. I have to be on at least 3000mg Vitamin d3 for life. My friend is older and her daughter was born with brain abnormalities"

4 / 10
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21 Report
  • chand...
  • Taken for less than 1 month
  • May 31, 2013

"I take this medicine for unexplained seizures. The doctor said they were caused by severe panic attacks. I don't know. It has helped a lot. But the side effects are terrible. Stomach burning, nausea, itching, drowsiness, and much more. I take 1000mg dose."

6 / 10
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24 Report
  • Anonymous
  • May 15, 2009

"Great medication for controlling petit mal seizures. Absolutely do not combine with alcohol. Went out drinking with friends while using Depakote and after only 2 margaritas, went home and had a grand mal seizure (first in 9 years). Otherwise, only other drawback to this medication is the price."

9 / 10
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30 Report
  • Mary...
  • Taken for 5 to 10 years
  • April 18, 2018

"Take 500 mg daily of Depakote. I have taken other epilepsy medications in the past that never caused symptoms quite like Depakote. Memory loss, tiredness, depression, if I forget to take it boom aura then seizure. Or a lot of times a bit after taking it boom severe auras. My doctor however still thinks this medication is the best fit for me. I don't think so. Absolutely hate the side effects of this medication."

2 / 10
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15 Report
  • Annloss
  • November 23, 2016

"It was bad. It made me gain weight. It made me have tremors ,which will never completely go away now.I couldn't hold plates or hold cups without shaking. My head started shaking. My new Neurologist took me off of them. I was on them for over 20 yrs. I would strongly think about other meds before taking this one considering the side affect can't go away immediately or not at all ."

3 / 10
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17 Report
  • Anonymous
  • May 8, 2008

"My 9 year old daughter has used Depakote for 2 years now for seizure disorder. I am happy with it as there are little side effects. We increased the dose when a seizure occurred. When the dose is high enough it helps with her migraines as well. She gained 5 pounds but we keep it down with a healthy diet. "

8 / 10
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30 Report
  • Anonymous
  • July 14, 2011

"I have taken Depakote for 13 years. Tried Dilantin and Lamictol at one point. They never fully stopped the seizure activity. Once I have learned to take my pills faithfully and have the correct dose it has become a HUGE BLESSING in my life. I am "normal". I have some of the side effect (weight gain, depression, hair falls out) but to me it is worth it to lead a normal functioning life. I also went through pregnancy on Depakote and I have a healthy 2 year old."

9 / 10
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25 Report
  • Anonymous
  • Taken for 10 years or more
  • August 16, 2013

"I was on Depakote for many years and in 2001 I had a case of a high fever which was finally diagnosed as Drug Related Hepatitis after 3+ weeks in the hospital and having almost every test under the sun. After I was taken off Depakote my fever went down and I lost approximately 15 pounds."

5 / 10
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21 Report
  • Eddie
  • Taken for 2 to 5 years
  • March 31, 2022

"I'm epileptic I have been having seizures since my early teens I’m 52 now I was born with a tumor in my brain. The tumor has been removed but the damage of the scar tissue is causing me to have seizures. I have been taking Depakote 2000mg a day and I take with it Keppra 1000mg a day for 2 years and the side effects suck, I can’t sleep, I stutter, I’m always anxious and have tremors. I have my ups and downs mood swings, I lost my hair, I’m easily angered or frustrated and nervous. I also have high blood pressure now and have to take high blood pressure meds. I smoke THC and CBD to help. I’m usually nauseous and I have digestive problems if you know what I mean. I still have seizures mainly blackouts I haven’t had a grandmal seizure for a bit. But I would like to know if anyone came down with high blood pressure when started taking the meds?"

1 / 10
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6 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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