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User Reviews for Seroquel

Seroquel has an average rating of 6.7 out of 10 from a total of 428 ratings on Drugs.com. 60% of those users who reviewed Seroquel reported a positive effect, while 20% reported a negative effect.

Condition Avg. Rating Reviews Compare
Bipolar Disorder  
6.7
348 reviews 30 medications
Schizoaffective Disorder  
7.4
42 reviews 27 medications
Schizophrenia  
6.3
38 reviews 47 medications
Summary of Seroquel reviews 6.7 428 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Seroquel

ezpz1 May 8, 2021

For Bipolar Disorder: “I was prescribed Seroquel 100mg as a mood stabilizer (for Dysthymia and Generalized Anxiety Disorder) by psychiatrist to be taken alongside 200mg Wellbutrin daily. It knocked me out the first time I took it and I noticed my blood pressure dropped sharply, but I felt good in the morning. After 3 weeks I started to feel like a zombie and developed severe constipation, then; suddenly, a feeling of internal tremor, so I contacted my Dr to stop. I slept 2 hours a night for about a week; had horrid nightmares, sleep paralysis, and severe mood swings and panic attacks. I was put on Xanax for the panic, but also developed muscle twitching all over my body that continued at night, waking me up. It's now been 40 days since I stopped taking the Seroquel. My mood is okay, but I still have (slightly less) muscle twitches in the day and night. I wonder if I'll ever be normal again. I'm so angry this was prescribed without explanation, for a minor condition when its effect on me has been far more deleterious to my life than my original condition.”

1 / 10
Maz · Taken for 1 to 6 months May 3, 2021

For Bipolar Disorder: “Serequel has helped me through psychosis from Bipolar 1, I was paranoid to the point I struggled to leave the house and was convinced there was cameras in my walls and TV, on top of that I was seeing people in my room and I was literally scared all the time. I started out on 50 mg twice a day then 100 mg twice a day at the moment I am happy at this dose, I can sleep and I still get paranoid thoughts but I can easily push them aside where as before it was constant thoughts flying around my brain. I considered suicide many times before this drug and literally without it I don't think I would be here. You have to give this drug time to work and yes you get side effects , dry mouth tiredness and for me nausea but that outweighs the alternative.”

10 / 10
Eveflower · Taken for less than 1 month April 27, 2021

For Bipolar Disorder: “This drug is awful. I became a zombie. My muscles began twitching and I felt like I was hit by a truck after taking for 10 days. I stopped it and immediately felt better and actually felt my emotions again. I do not recommend.”

1 / 10
anon · Taken for less than 1 month February 6, 2021

For Bipolar Disorder: “I thought writing this was important as there is so many negative reviews on here. I was so close to giving up and every single medication I put in my body would send me into a borderline psychosis. I had the prescription for Seroquel for awhile before I could convince myself to take it. I am so glad I did. Still adjusting the dosage so I am not 100% where I need to be, but a low dose of this has given me a sense of hope that I haven't felt in 7 months. I was so broken from Anxiety/adhd and I can finally see a light at the end of the tunnel from Seroquel. Felt effects within the first few days and still improving with dosage adjustments. Don't give up!!!!! xxx”

10 / 10
Mrmeds August 29, 2019

For Schizophrenia: “This drug has really helped me with the voices and the paranoia. I have been on it for nearly 3 years. I have been on pretty much every antipsychotic there is and have been dealing with this illness for a long, long time. The downside is that you will gain weight. I have lost some of it by reducing calories and taking metformin. Walking seems to help too. If you do take this one, stay as active as you can to avoid diabetes because as my psychiatrist told me "It will happen eventually" Also, I adopted a vegatarian diet to help lower other risks with this one. The other downside is that it can make you very tired. I take 400mg at night and 75mg in the morning and another 75mg in the afternoon. I still hear voices and don't want to be around other people but it is much more manageable and I can at least have some kind of life. To be honest, I probably would have killed myself if it were not for this drug. I am surprised I even wrote this as I am a very paranoid person.”

10 / 10
Molly · Taken for less than 1 month August 28, 2019

For Bipolar Disorder: “This medication has saved my life. I was having the worst episodes ever high low high low, no sleep, totally impulsive on the downward spiral to self destruction. Spending money running around town all hours, telling off people at work... then the crash. Sobbing in my doctor's office, she wrote the script for Seroquel. I had zero faith, because all the anti-depressants etc. she'd tried me on never worked to calm the chaos/PTSD reactivity in my head. I was ready to end it all. Thank goodness I filled the script and took it. I slept! That in itself is a miracle. I kept my job, and I'm hopefully on a journey to wellness. My mind is calmer. I can think one thing after another in a logical order instead of a cloud of white noise and traumatic memories flashing. I think with this med and some good PTSD therapy I might have a second chance... at life. I don't care if I gain a little weight... I want to live without constant chaos. So grateful.”

8 / 10
Matt · Taken for 6 months to 1 year September 13, 2020

For Schizoaffective Disorder: “Seroquel saved my life. I was diagnosed with schizoaffective disorder at 16 ( I'm 18 now) and I’ve tried almost all second-generation antipsychotics since I was 13. ALL made me experience horrid side effects (extrapyramidal effects, paranoia, vomiting, emotionally flat). Seroquel within 2 days of taking it helped me feel relatively normal...with NO akathisia/extrapyramidal effects. I can sleep, I don’t feel anywhere as paranoid, the delusions have significantly decreased. The only thing that is a little funky is the hunger, but I can manage that. This drug has helped me live a normal life. I’m at 300mg now and this is my safe spot. For anyone considering this medication, go for it. It’s the only antipsychotic that has not made me crawl out of my skin and “die” mentally. Genuinely a wonderful drug.”

9 / 10
A-nonny-mouse · Taken for 2 to 5 years October 13, 2019

For Bipolar Disorder: “If you have Bipolar Disorder type II, please learn as much as you can about this condition from professional, reputable sources so you can make informed decisions about treatment and management options. This is a treatable, manageable illness, take hope in that. After 20+ years struggling to "cure" myself "naturally" & being miserable, dangerously depressed & dysfunctional, I finally decided to try psych medication. I found a doctor who SPECIALISES in this disorder and is up to date with the latest research findings in this specific condition. If you don't like your current GP or Psych's attitude, find someone else! I started a combo of Lamictal (AM & PM) & Seroquel (Only PM - makes you drowsy). I kept a daily mood diary & it took 3 months for my mood to fully stabilise. To help the bipolar depression, we added bupropion & N-Acetyl Cysteine, a supplement (all based on clinical research!). For 5 years now, I’ve had my life back. Deciding to take this medication saved my life.”

7 / 10
Sam April 28, 2020

For Schizoaffective Disorder: “10 years ago, while in college, I had a marijuana induced psychosis (didn't know this was possible) & wound up in the ER. Don't remember 95% of events but apparently I thought the hospital staff was trying to kill me, was uncooperative & pulling IVs out of my arm. They had an officer restrain me & he decided it was a good idea to tase me in the head. I fell down and suffered a fractured skull, concussion & the next day my nightmare began. I developed PTSD, couldn't sleep, panic attacks, hyper-vigilance etc. I was close to ending my life when I found a $300/hr Psych. who started me on Seroquel immediately. Within 24hrs I felt almost as good as before the incident happened. I was on it for a year and stopped as the doc told me I could stop if I didn't have any psychoses in that time. Very grateful for that doc and Seroquel. Everyone should have medical care like I found regardless of their ability to pay $300/hr; fortunately my parents could afford it.”

10 / 10
Chuck · Taken for less than 1 month November 28, 2019

For Bipolar Disorder: “Seroquel is an excellent choice for stabilizing the mood and improving sleep in the context of a Bipolar disorder. I have Bipolar II mood disorder and recently experienced chronic sleeplessness and angry-agitated moods. The day of my medical appointment I became overtly angry in two separate social circumstances. These angry reactions are very hurtful to those who experience the triggered anger. Seroquel (an antipsychotic and mood stabilizer) calms down the CNS agitation, reduces negative thoughts and improves quality of sleep: very important for our overall health and well-being!”

8 / 10
L · Taken for less than 1 month May 3, 2020

“This seroquel has so far been a game changer for me. I am 25 year old female, roughly 55kg, insomnia sufferer. Usually have very broken and inconsistent sleeping patterns, came to the conclusion that I probably needed sleep assistance after years of issues. I take 50mg at night around 11-12 and it knocks me out within half an hour. Don’t make the mistake of staying up on your phone or doing other things because you will end up staying awake in a daze raiding the fridge. Take it when you are ready to switch off and go to bed. I have noticed I wake up ravenous so I do cardio and caffeine in the morning to avoid weight gain - I can see how easy it could be to gain weight on this drug. Overall it works well for me. I could probably be getting away with 25mg instead of 50mg but I have such sleep anxiety that 50mg is my safe amount that I know will knock me out without overthinking.”

9 / 10
Winterviolet · Taken for less than 1 month November 27, 2019

For Schizophrenia: “I started 100 mg of Seroquel after Abilify failed at managing my symptoms. On Abilify I was waking with constant anxiety and restless leg syndrome. Once I started taking Seroquel anxiety and restless leg syndrome disappeared and I’m feeling the best I’ve felt in a long time. The first week I was tired but after that passed it’s been nothing but a sense of inner peace and calmness. So happy I tried this medicine again. I think the dose of 100 mg is a perfect dose for me.”

10 / 10
Jenny · Taken for less than 1 month September 5, 2020

For Bipolar Disorder: “I got very sick, and was put into the ICU for a very long time which caused ICU Delirium and Depression. I had been on Cymbalta, but they changed it to Seroquel. My friends who are nurses make jokes about how awesome Seroquel is for shutting patients up and making them comply. I felt awful on this drug. Leg spasms, drooling, worsened diabetes, etc. They didn't tell me that they'd put me on it. When someone finally told me, I demanded they take me off of it, and the drooling and spasms stopped almost immediately. And I was able to stay awake, and think more clearly. And able to participate in physical therapy. I didn't notice any mood improvements and in fact I was incredibly depressed, but being in the ICU is traumatic, and I had a machine breathing for me, and I was trying to process having almost died. I would recommend trying just about everything else first. I've told my doctors they're never putting me on it again.”

1 / 10
Northern Guy · Taken for 5 to 10 years October 22, 2012

For Generalized Anxiety Disorder: “This medicine is great for daytime anxiety or anxiety with insomnia. Doctors give way too much of this 300mg, 500mg, etc. to non-manic patients when much smaller dosages will work. I used a HALF TABLET (12.5mg) for sleep. Lately I used 1/4 tablet (one in morning and one in afternoon) to lower base anxiety level. You don't need to be knocked out to get relief from anxiety!”

8 / 10
Maxed · Taken for 2 to 5 years September 4, 2019

For Bipolar Disorder: “I have bipolar mania with stages of depression. It has been like this since I was very young. It comes along with episodes of mood swings. I am on 25 mg of Seroquel now and have been on both 50mg and 100 mg. 25 mg does great things for me. No more sleepless nights. No more intense spending sprees. No more major anxiety most of the time. A lot less depression and a lot less irritability I experienced as well. I get tired and a little unmotivated in the morning, but I have coffee and breakfast and I'm good. Weight gain is the other concerns but I have controlled it with walking good amounts each day. Well worth a try and definitely something to consider for a bipolar patient.”

8 / 10
Andrea · Taken for 10 years or more September 2, 2020

For Bipolar Disorder: “I have Affective bipolar disorder and took Seroquel for 12 years started at 100mg , last 8 years 300mg night. I had psychotic suicidal depression. Yes it made me sleep well except towards end restless legs. It never stopped the depressions from recurring nor could I sleep with it during the bouts. A year ago a psych stopped it cold turkey or over 5 days. Instantly I developed tardive dyskinesia TD a debilitating progressive neurological condition . Very uncomfortable, painful and no, I would not recommend it. I am 63 having to start a new life, homebound, super self conscious of my face, avoid meeting people”

3 / 10
k · Taken for 1 to 6 months July 26, 2019

For Bipolar Disorder: “I have struggled with depression and anxiety for about 14 years (I am 27). The past 2 years have been the hardest, I have been suicidal every day and I had lost all hope. For about 10 months I have been on: lexapro for 3 months, then effexor for 3 months, and now pristiq for 4 months. I have also had regular talk therapy with a psychologist. About a month ago a psychiatrist prescribed seroquel 25mg as an add on to my pristiq. The past 4 weeks have been the best I have felt in many years. I feel much lighter (as in, the heaviness of depression has lifted), much more positive, I haven't been ruminating about the past. Seroquel has truly made a world of difference. I truly think its very possible I could have ended up a suicide eventually without it. It's only been 4 weeks, but hopefully the effects continue. It's worth a try if nothing else has worked.”

10 / 10
Tayson · Taken for 1 to 6 months April 27, 2019

For Bipolar Disorder: “I was put on Seroquel 4 months ago as before I was on it I had really bad, uncontrollable mood swings throughout the day. After about 3 months of really struggling I had a really bad depressive episode where I was convinced people at work were out to get me. My mind was racing extremely fast, I had a huge amount of anxiety, and was extremely stressed out combined with really low sinking depression. I had to spend 24 hours in a hospital and they put me on Seroquel and a few other medications. The Serooquel has completely saved my life, along with my support system. I had low sinking moods occasionally for about 2 months and had my dosage upped. Now I'm at 200mg every night and am about 90% stable. I was diagnosed Major Depression W/ Psychotic Features but since have been diagnosed with Bipolar II. If you're having mood swings or intense anxiety with an out of control racing mind please don't force yourself to push through it. Try seroquel and it might give you your life back like it did me.”

9 / 10
lipelips · Taken for 2 to 5 years September 12, 2020

For Schizoaffective Disorder: “My experience with quetiapine is amazingly positive. I tried, invega (that was bad) with unsuccessful results. I take Queatipine at a dose of 50mg at night and it makes me so much more relaxed and without any kind of bad feelings or thoughts. If you wanna be healthy and active during your days, this drug is highly recommended. In my case is used during night before sleep. It works!”

10 / 10
Mick · Taken for less than 1 month January 24, 2020

For Bipolar Disorder: “Thank you everyone for sharing your views. For those that Seroquel has helped, how many weeks did it take to feel relief from the agitation? I have been on this for a week and don't feel less agitated yet, only too drowsy to yell as much after I take it for a period.”

6 / 10
123 · Taken for 5 to 10 years June 4, 2020

For Schizophrenia: “I used to take this drug Seroquel for 7 years. The only side effects I had was sleeping too much, no way to wake up in the morning and "still sleeping" for 1st hour of being awake. Once I threw up breakfast because my body was just not working yet. And I was always putting guilt on me, because I didn't know that this is pill side effect. I used to think I am lazy, because I couldn't wake up. When having job, I always needed someone who woke me up, because I always turned off the alarm unaware, while sleeping. Only now when I changed pills and can normally wake up I see that I am not lazy and I am very happy for that fact! Another side effect was muscles cramps in legs - when I went to bed, I couldn't stay still, I had to move my legs because of some weird "muscle tightens". This happened occasionally. The side effects were not so terrible. It didn't do any harm to mind and emotions.”

8 / 10
Polarizer · Taken for 1 to 6 months January 3, 2020

For Bipolar Disorder: “This drug absolutely did not work for me. Well the sleeping part worked.... I never slept so much in my life. Instead of waking up from 12 hours of sleep feeling well rested, I woke up angry and wanting to punch someone in the face. Sure I can have anger outbursts but only while on Seroquel did I want to punch someone. Started low at 25mg and my doctor kept increasing my dosage to 100.mg At 100mg, I would sleep 18 hours straight and my days and nights were blurred. The anger caused me great urges to drink alcohol, which is ironic because I don't even like alcohol. Eventually just stopped cold turkey and to this day I have never woken up as miserable as I was on Seroquel. Also I gained 60 pounds in a little over 2 months and had severe impotence. So definitely not for me.”

2 / 10
Zully May 2, 2020

For Bipolar Disorder: “I can, now, see my own sign of mania or depression (having had Dialectical Behavioral therapy for six months). With that said, the meds are not miracles and after some dialectical treatment to add to my “tool box”... seroquel really helps. When I am restless, racing thoughts and moody I feel well balance after about 48-72 hours after using “coping skills” plus adding seroquel to prevent lack of sleep which induces worsening of thoughts, moods, eating, etc. For me, it’s very helpful to have self-relaxation skills to level my reactions. I give this medication, after months of skill work, A++. My experience is not to say it is 100% fluent to all bipolar sufferers. Good thing DBT is not a medication so won’t hurt to try it as a “tool”. The side-effects are mild. It does make me drowsy and sometimes do get oily face... yet, I can accept that over extended episodes. I also have to keep drinking lots of water as dry mouth is mild and do feel thirsty.”

10 / 10
EpGuy February 13, 2021

For Bipolar Disorder: “Seroquel has been nothing short of a miracle for my depression, anxiety, sleep, and mood. I take 800 mg at night around 10 pm and it has helped me in ways I couldn’t have imagined. The side effect of weight gain has been significant but I’ll gladly take the trade of being fat.”

10 / 10
veronikanchad · Taken for 1 to 6 months August 27, 2019

For Bipolar Disorder: “Started at 25mg felt groggy in am but it passed after a week then increased to 50mg. My moods are stable but I don't feel drugged up. At least I'm sleeping well now. At this dose it still lets me express emotions. Doesn't interfere with my daily activities at all. Just wish I'd taken it years ago.”

10 / 10
Cutie Boots · Taken for 1 to 6 months April 23, 2020

For Schizophrenia: “My son has autism and anxiety. He started experiencing psychosis/auditory hallucinations at age 18...so bad he would yell and get very angry. We have started Seroquel, on it over 2 months now, some improvement but not great. His doc has now upped it from 25mg and we are now 500 mg. Along with Mirtazipine and Ativan for sleep. Hoping we can stay ahead of of his episodes instead of chasing them. I’ll give an update. Super helpful to read others reviews. praying we see some good results.”

7 / 10
Travis · Taken for 1 to 6 months February 19, 2020

For Bipolar Disorder: “I have been on Seroquel off and on for three years. I have tried other meds for my Bipolar Disorder but nothing has worked better for me. I feel the only drawback is waking up in the morning with a cloudy head and dry mouth.”

9 / 10
AnnieFromAfrica August 30, 2013

For Bipolar Disorder: “I too gained masses of weight taking Seroquel but lost it all (35lb) in 6 months by healthy eating & being AWARE of the pitfalls. Seroquel does not make you gain weight. Seroquel makes you crazy HUNGRY craving all the bad stuff - salt/sugar/fried food for me. The secret is to ANTICIPATE your munchies. Prepare a large but healthy snack in advance or save half your evening meal and have it at bedtime just before you take your meds. This really worked for me. Taking my meds on a full stomach took the cravings away.”

8 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.