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Generic name: brexpiprazolebrex-PIP-ra-zole ]
Drug class: Atypical antipsychotics

Medically reviewed by Sanjai Sinha, MD. Last updated on Feb 20, 2023.

What is Rexulti?

Rexulti is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Rexulti is used to treat the symptoms of schizophrenia.

Rexulti is also used together with other medications to treat major depressive disorder in adults.


Rexulti is not approved for use in older adults with dementia-related psychosis.

Some young people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Rexulti is not approved for use by anyone younger than 18 years old.

Before taking this medicine

Rexulti may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

You should not use Rexulti if you are allergic to brexpiprazole.

Tell your doctor if you have ever had:

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking Rexulti without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of brexpiprazole on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Rexulti is not approved for use by anyone younger than 18 years old.

How should I take Rexulti?

Take Rexulti exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take Rexulti with or without food.

Drink plenty of fluids, especially in hot weather and during exercise. You may get dehydrated easily while taking Rexulti.

You should not stop using this medicine suddenly. Stopping suddenly may make your condition worse.

Rexulti may cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking this medicine.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Schizophrenia:

Initial dose: 1 mg orally once a day on Days 1 through 4
Titration regimen: Based on clinical response and tolerability, titrate to 2 mg once a day on Days 5 to 7, then to 4 mg once a day on Day 8.
Maintenance dose: 2 to 4 mg orally once a day
Maximum dose: 4 mg/day

Use: Treatment of schizophrenia

Usual Adult Dose for Depression:

Initial dose: 0.5 mg to 1 mg orally once a day
Titration regimen: Based on clinical response and tolerability, dose increases should be done at weekly intervals; titrate to 1 mg once a day, then up 2 mg once a day.
Maintenance dose: 2 mg orally once a day
Maximum dose: 3 mg/day

Comment: Healthcare providers should periodically reassess the need for maintenance treatment.

Use: Adjunctive treatment of major depressive disorder (MDD)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid becoming overheated or dehydrated in hot weather. Brexpiprazole can make it harder for your body to control its own temperature. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.

Rexulti side effects

Get emergency medical help if you have signs of an allergic reaction to Rexulti: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

High doses or long-term use of Rexulti can cause a serious movement disorder that may not be reversible. The longer you use this medicine, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • trouble swallowing;

  • feelings of warmth, intolerance to heat;

  • a seizure (convulsions);

  • a light-headed feeling, like you might pass out;

  • high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;

  • low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing;

  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors; or

  • signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common Rexulti side effects may include:

  • weight gain; or

  • feeling restless or being unable to sit still.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rexulti?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with brexpiprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Rexulti (brexpiprazole) is in a class of medicines known as atypical antipsychotics used to treat schizophrenia and depression. Although your results may vary, the atypical antipsychotic class is often associated with weight gain, possibly due to increased appetite, less physical activity because of side effects like drowsiness, or metabolic changes. Continue reading

Rexulti (generic name: brexpiprazole) is an atypical antipsychotic used to treat adults with schizophrenia or depression. In Rexulti studies, some people started to see results 1 or 2 weeks after starting treatment, but the best results were seen at the end of 6 weeks. Continue reading

Rexulti (brexpiprazole) is an atypical antipsychotic used to treat adults with schizophrenia or depression. In a 6-week long study in adults, adding Rexulti to ongoing antidepressant treatment led to a 62% greater reduction in symptoms of depression. Continue reading

Rexulti (brexpiprazole) works by altering chemicals in the brain that can lead to schizophrenia or depression. It is classified as a serotonin-dopamine activity modulator (SDAM) and works at serotonin and dopamine receptors in the brain. It is used to treat symptoms of schizophrenia, and in combination with other medicines for depression. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rexulti only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.