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Rexulti

Generic Name: brexpiprazole (brex PIP ra zole)
Brand Names: Rexulti

What is Rexulti?

Rexulti (brexpiprazole) is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Rexulti is used to treat the symptoms of schizophrenia.

Rexulti is also used together with other medications to treat major depressive disorder in adults.

Important information

Rexulti is not approved for use in psychotic conditions related to dementia.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Rexulti is not approved for use by anyone younger than 18 years old.

Before taking this medicine

Rexulti is not approved for use in psychotic conditions related to dementia. Rexulti may increase the risk of death in older adults with dementia-related conditions.

You should not use Rexulti if you are allergic to brexpiprazole.

To make sure Rexulti is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • high cholesterol or triglycerides (a type of fat in the blood);

  • heart disease, high or low blood pressure;

  • a history of low white blood cell (WBC) counts;

  • a history of heart attack or stroke;

  • a history of seizures, head injury or brain tumor;

  • a personal or family history of diabetes or high blood sugar; or

  • trouble swallowing.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

It is not known whether Rexulti will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Rexulti on the baby.

It is not known whether brexpiprazole passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Rexulti is not approved for use by anyone younger than 18 years old.

How should I take Rexulti?

Take Rexulti exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food.

Drink plenty of fluids, especially in hot weather and during exercise. You may get dehydrated easily while taking Rexulti.

You should not stop using Rexulti suddenly. Stopping suddenly may make your condition worse.

Rexulti may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking this medicine.

Store at room temperature away from moisture and heat.

Rexulti dosing information

Usual Adult Dose of Rexulti for Schizophrenia:

Initial dose: 1 mg orally once a day on Days 1 through 4
Titration: Based on clinical response and tolerability, titrate to 2 mg once a day on Day 5 through Day 7, then to 4 mg once a day on Day 8
Target Dose: 2 to 4 mg orally once a day
Maximum dose: 4 mg per day

Use: Treatment of schizophrenia.

Usual Adult Dose of Rexulti for Depression:

Initial dose: 0.5 mg or 1 mg orally once a day
Titration: Based on clinical response and tolerability, dose increases should be done at weekly intervals; titrate to 1 mg once a day, then up 2 mg once a day.
Target dose: 2 mg orally once a day
Maximum dose: 3 mg per day

Use: Adjunctive treatment of major depressive disorder.

Usual Geriatric Dose of Rexulti for Depression:

Dose selection should be cautious, usually starting at the low end of the dosing range.

Usual Geriatric Dose of Rexulti for Schizophrenia:

Dose selection should be cautious, usually starting at the low end of the dosing range.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Rexulti?

Rexulti may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated in hot weather. Rexulti can make it harder for your body to control its own temperature. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.

Rexulti side effects

Get emergency medical help if you have signs of an allergic reaction to Rexulti: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of Rexulti can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take Rexulti, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • severe agitation, distress, or restless feeling;

  • a light-headed feeling, like you might pass out;

  • trouble swallowing;

  • feelings of warmth, intolerance to heat;

  • thoughts about suicide or hurting yourself;

  • twitching or uncontrolled muscle movements;

  • a seizure (convulsions);

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, weight loss;

  • low blood cell counts - sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, red or swollen gums, skin sores, cold or flu symptoms, cough, trouble breathing; or

  • a severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common Rexulti side effects may include:

  • weight gain;

  • dizziness, drowsiness; or

  • agitation, feeling restless.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Rexulti?

Many drugs can interact with brexpiprazole. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • an antibiotic or antifungal medicine;

  • an antidepressant;

  • antiviral medicine to treat hepatitis C or HIV;

  • heart rhythm medicine; or

  • seizure medicine.

This list is not complete and many other drugs can interact with brexpiprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Rexulti.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rexulti only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 1.01. Revision Date: 2015-08-26, 3:13:49 PM.

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