Rexulti Alternatives Compared
| Rexulti | Zoloft | Wellbutrin XL |
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| Rexulti brexpiprazole | Zoloft sertraline | Wellbutrin XL bupropion |
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Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression. Most people experience some improvement in their symptoms within 1 to 2 weeks of starting... View more |
Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Obsessive Compulsive Disorder, Panic Disorder, Major Depressive Disorder... View more |
Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Choose a suggestion below Depression
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| More about Rexulti (brexpiprazole) | More about Zoloft (sertraline) | More about Wellbutrin XL (bupropion) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Rexulti has an average rating of 6.4 out of 10 from a total of 364 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. |
Zoloft has an average rating of 7.2 out of 10 from a total of 1689 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
Wellbutrin XL has an average rating of 7.4 out of 10 from a total of 404 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full Rexulti side effects document. |
Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, xerostomia. See the full Zoloft side effects document. |
Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, xerostomia. See the full Wellbutrin XL side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Rexulti prices |
View all Zoloft prices and generic prices |
View all Wellbutrin XL prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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91 hours |
66 hours |
30 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 530 drugs are known to interact with Rexulti:
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A total of 636 drugs are known to interact with Zoloft:
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A total of 425 drugs are known to interact with Wellbutrin XL:
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| First Approval Date | ||||||||||||||||||||||||||
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July 10, 2015 |
December 30, 1991 |
August 28, 2003 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.