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Trintellix (vortioxetine) Disease Interactions

There are 5 disease interactions with Trintellix (vortioxetine):


Antidepressant/antipsychotic agents (Includes Trintellix) ↔ depression

Moderate Potential Hazard, Moderate plausibility. Applies to: Depression, Bipolar Disorder

Adult and pediatric patients with depression and other psychiatric disorders may experience worsening of their symptoms and may have the emergence of suicidal thoughts and behavior. Patients should be monitored appropriately and observed closely for worsening of their symptoms, suicidality or changes in their behavior, especially during the first few months of treatment, and at times of dose changes. Discontinuing the medication should be considered if symptoms are persistently worse, or abrupt in onset.


Antidepressants (Includes Trintellix) ↔ angle closure glaucoma

Moderate Potential Hazard, Moderate plausibility. Applies to: Glaucoma (Narrow Angle)

Some antidepressants exert mydriatic activity that can induce increased intraocular pressure and result in angle-closure (narrow angle) glaucoma in a patient with anatomically narrow angles who does not have a patent iridectomy. Prior to initiating therapy with these agents patients should be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure (e.g., iridectomy), if they are susceptible. The use of these drugs in patients with untreated anatomically narrow angles should be avoided.


Antidepressants (Includes Trintellix) ↔ bleeding

Moderate Potential Hazard, Moderate plausibility. Applies to: Bleeding

Some antidepressants should be administered with caution in patients with an increased risk for hemorrhage. Patients should be advised to immediately report any signs and symptoms suggestive of bleeding complications, including ecchymosis, hematoma, epistaxis, and petechia.


Vortioxetine (Includes Trintellix) ↔ hyponatremia

Moderate Potential Hazard, Moderate plausibility. Applies to: Hyponatremia, Dehydration, SIADH

Treatment with vortioxetine may cause hyponatremia, in many cases secondary to development of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Caution should be used when treating patients with hyponatremia or at greater risk of developing hyponatremia such as elderly patients, patients taking diuretics or those who are volume-depleted.


Vortioxetine (Includes Trintellix) ↔ mixed/manic episode

Moderate Potential Hazard, Moderate plausibility. Applies to: Depression, Bipolar Disorder, Mania

Therapy with vortioxetine may cause activation of mania and hypomania and should be used with caution in patients with personal or family history of mania, hypomania, bipolar disorder, and other mood disorders.

Trintellix (vortioxetine) drug interactions

There are 295 drug interactions with Trintellix (vortioxetine)

Trintellix (vortioxetine) alcohol/food interactions

There is 1 alcohol/food interaction with Trintellix (vortioxetine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.