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Trintellix Side Effects

Generic Name: vortioxetine

Note: This page contains side effects data for the generic drug vortioxetine. It is possible that some of the dosage forms included below may not apply to the brand name Trintellix.

In Summary

Common side effects of Trintellix include: diarrhea, male sexual disorder, and nausea. Other side effects include: constipation, dizziness, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vortioxetine: oral tablet

As well as its needed effects, vortioxetine (the active ingredient contained in Trintellix) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking vortioxetine, check with your doctor immediately:

Incidence not known:
  • Agitation
  • blood in the stool or urine
  • confusion
  • convulsions
  • decreased urine output
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • nausea or vomiting
  • nose bleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • shortness of breath
  • sweating
  • swelling of the face, ankles, or hands
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Minor Side Effects

Some vortioxetine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Difficulty having a bowel movement (stool)
  • dry mouth
Less common:
  • Bloated or full feeling
  • excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • unusual dreams
Incidence not known:
  • Acid or sour stomach
  • belching
  • blurred vision
  • change in taste
  • dizziness or lightheadedness
  • eye pain
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • heartburn
  • indigestion
  • loss of taste
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to vortioxetine: oral tablet


The most commonly reported side effects were difficulties in sexual desire, sexual performance, sexual satisfaction, and nausea.[Ref]


Very common (10% or more): Difficulties in sexual desire, sexual performance, sexual satisfaction (up to 34%)
Common (1% to 10%) Abnormal dreams
Rare(less than 0.1%): Mania, hypomania[Ref]


Frequency not reported: Angioedema[Ref]

Nervous system

Common (1% to 10%): Dizziness
Frequency not reported: Serotonin syndrome, dysgeusia, vertigo[Ref]


Very common (10% or more): Nausea (up to 32%), diarrhea (up to 10%)
Common (1% to 10%): Dry mouth, constipation, vomiting, flatulence
Frequency not reported: Dyspepsia[Ref]


Frequency not reported: Discontinuation symptoms such as headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, runny nose[Ref]


Common (1% to 10%): Pruritus[Ref]


Frequency not reported: Flushing[Ref]


1. "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.

It is possible that some side effects of Trintellix may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.