Trintellix Side Effects
Generic name: vortioxetine
Medically reviewed by Drugs.com. Last updated on Nov 30, 2020.
Note: This document contains side effect information about vortioxetine. Some of the dosage forms listed on this page may not apply to the brand name Trintellix.
Common side effects of Trintellix include: diarrhea, male sexual disorder, and nausea. Other side effects include: constipation, dizziness, and vomiting. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to vortioxetine: oral tablet
Oral route (Tablet)
Warning: Suicidal Thoughts and BehaviorsIncreased risk of suicidal thinking and behavior in pediatric and young adult patients taking antidepressants.Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors.Vortioxetine hydrobromide is not approved for use in pediatric patients.
Side effects requiring immediate medical attention
Along with its needed effects, vortioxetine (the active ingredient contained in Trintellix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking vortioxetine:
Incidence not known
- blood in the stool or urine
- decreased urine output
- difficulty swallowing
- fast or irregular heartbeat
- hives, itching
- increased sweating
- increased thirst
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- muscle pain or cramps
- nausea or vomiting
- nose bleeds
- overactive reflexes
- poor coordination
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red or purple spots on the skin
- swelling of the breasts or unusual milk production
- swelling of the face, ankles, or hands
- talking or acting with excitement you cannot control
- tightness in the chest
- trembling or shaking
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting blood
Side effects not requiring immediate medical attention
Some side effects of vortioxetine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty having a bowel movement (stool)
- dry mouth
- Abnormal ejaculation
- bloated or full feeling
- decreased sexual performance or desire
- excess air or gas in the stomach or intestines
- itching skin
- passing gas
- unusual dreams
Incidence not known
- Acid or sour stomach
- blurred vision
- change in taste
- dizziness or lightheadedness
- eye pain
- feeling of constant movement of self or surroundings
- feeling of warmth
- loss of taste
- redness of the face, neck, arms, and occasionally, upper chest
- sensation of spinning
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to vortioxetine: oral tablet
The most commonly reported side effects included nausea, sexual dysfunction, headache, diarrhea, and dry mouth.[Ref]
Nausea usually occurred during the first week of treatment, with up to 20% of patients reporting nausea within 1 to 2 days of starting treatment. Nausea occurred more frequently in female patients, and in patients 65 years and older.[Ref]
Very common (10% or more): Nausea (up to 42%), constipation (up to 15%)
Uncommon (0.1% to 1%): Abdominal distention, epigastric discomfort, gastritis, salivary hypersecretion
Frequency not reported: Gastrointestinal bleeding
Very common (10% or more): Sexual dysfunction (up to 34%)
Uncommon (0.1% to 1%): Micturition urgency, nocturia
Very common (10% or more): Headache (up to 14.7%)
Common (1% to 10%): Dizziness, sedation, somnolence
Frequency not reported: Serotonin syndrome
Postmarketing reports: Seizure
Common (1% to 10%): Abnormal dreams, insomnia
Uncommon (0.1% to 1%): Bruxism, derealization, initial insomnia, middle insomnia, restlessness, sleep disorder, tension
Frequency not reported: Anger/sudden outbursts of anger, dyssomnia, mood swings, poor quality sleep, terminal insomnia, withdrawal symptoms
Postmarketing reports: Aggression, agitation, hostility, irritation[Ref]
Common (1% to 10%): Accidental overdose, asthenia, fatigue
Uncommon (0.1% to 1%): Malaise[Ref]
Uncommon (0.1% to 1%): Flushing, night sweats, rash
Frequency not reported: Contusion, ecchymosis
Common (1% to 10%): Arthralgia, back pain
Frequency not reported: Bone fractures, muscle tension[Ref]
Common (1% to 10%): Decreased appetite
Uncommon (0.1% to 1%): Increased low density lipoprotein/blood cholesterol/blood triglycerides, weight gain
Common (1% to 10%): Nasopharyngitis
Frequency not reported: Epistaxis[Ref]
Uncommon (0.1% to 1%): Chest discomfort, hypotension, increased heart rate, prolonged electrocardiogram QT
Frequency not reported: Hemorrhage[Ref]
Uncommon (0.1% to 1%): Dry eye
Rare (0.01% to 0.1%): Mydriasis[Ref]
Postmarketing reports: Anaphylaxis, hypersensitivity reactions
Postmarketing reports: Hyperprolactinemia
Frequently asked questions
- Does Trintellix (vortioxetine) cause weight gain or loss?
- How long does it take for Trintellix (vortioxetine) to start working?
- Is Trintellix (vortioxetine) good for anxiety?
- Shall I take Trintellix (vortioxetine) in the night or morning?
- Can I take Cymbalta (duloxetine) and Trintellix (vortioxetine) together?
- Is Trintellix the same as Brintellix?
More about Trintellix (vortioxetine)
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 963 Reviews
- Drug class: miscellaneous antidepressants
- FDA Approval History
Related treatment guides
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Trintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.
3. Cerner Multum, Inc. "Australian Product Information." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.