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User Reviews for Trintellix to treat Major Depressive Disorder

Trintellix has an average rating of 6.0 out of 10 from a total of 359 ratings for the treatment of Major Depressive Disorder. 48% of those users who reviewed Trintellix reported a positive effect, while 34% reported a negative effect.

Trintellix Rating Summary

6.0/10 average rating

359 ratings from 380 user reviews.

Compare all 54 medications used in the treatment of Major Depressive Disorder.

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Reviews for Trintellix

Kells80 · Taken for 1 to 6 months May 28, 2021

“I have been on Trintellix switched from Viibryd about 3 to 4 months now. It was hard switching over, I went thru a lot of emotions, crying, laughing, anger. It was strange. Then for about a week I felt “nothing” I was flat. No emotions. About a week long of being emotionless I felt normal again. This was being on 10 mg. Then I started to feel worthless etc, still have anxiety and I still have to take my clonazepam for it. My Dr. upped my med to 20mg, I feel a bit anxious, kind of edgy. Is this normal? I would maybe expect it to be since he doubled it, but I have been on 20 for 5 days now and I feel like tapering back to 10. Anyone have this experience going up?”

8 / 10
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NoName · Taken for 1 to 2 years April 23, 2021

“I have been on Trintellix for about 1 year. I tried Escitalopram and Zoloft before trying Trintellix. Trintellix was ok for me. I realised that I was also just feeling ok on it. I wanted to feel better then ok. I spoke to my Doc about it, she added Bupropion with Trintellix. The Bupropion was bad for me. She is now switching me from Trintellix to Effexor XR. I shall see if this is better.”

6 / 10
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HumDucky · Taken for 5 to 10 years April 14, 2021

“I have tried every single antidepressant on the market over the past 10 years. They either did not work or caused terrible side effects or I needed a booster med usually an antipsychotic to make it work. I gained 60lbs in 3 years taking other meds. My doctor at first gave me 5mg of Trintellix and then upped me to 10. At 10mg I still needed the booster meds. She upped me to 15mg and took me off the booster meds. I lost around 15lbs and was feeling somewhat better. After upping me 6 weeks ago to 20mg (maximum dose) I am feeling fantastic. Lots of energy, positive thoughts, enjoying life for the first time in 10 years. I have been on Trintellix in some form for almost 5 years and it took that long to get the dosage right. I am grateful for my doctor for sticking with me until we finally found the right combination. I feel like I have a whole new life right now. Trintellix did not cause me weight gain. Abilify, Rexulti, and Bupropion XL did.”

9 / 10
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Pandora · Taken for 1 to 6 months June 7, 2020

“I'm bipolar 2 and have suffered with major depression for so many years now. I have tried most antidepressants and with no luck! My latest bout lasted 3 very long years..3 very dark years. I had enough of fighting my own brain and decided that I should see my psychiatrist because I knew in my heart that this wouldn't get better and I would wake up in 3 more years worse and wondering where my life has gone. I did it and I've been on lamictal and trintellix for a few months now. I promise you it's the best result I have ever had. Zero side effects unless you go up in mg too fast. So far? I'm happier. I have more motivation. I have more clarity. I shower daily - most days lol And, more importantly, I have hope. Not all meds are meant for everyone and they are very different just we are as people. Please don't give up if trintellix isn't "Your drug" Blessings over you all, Pandora.”

10 / 10
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Braxton · Taken for less than 1 month October 5, 2020

“I have tried all the SSRI's and some SNRI's. literally, prozac, lexapro, citalopram, well butrin, amitriptyline, remeron, venlafaxine, pristiq, paxil. I had slight symptom relief with lexapro however, the side effects outweighed the benefit. I started on 5 mg of trintellix, I take it in the morning as it is a little stimulating for me, after the first week I went to 10 mgs. The only side effect I experienced is the nausea and that only lasted for about 4 days and it was not severe. I feel like a completely different person. If others have not worked for you give this one a try. It has given me my emotions and concentration back.”

10 / 10
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Juliet · Taken for 6 months to 1 year February 10, 2020

“Trintellix has changed my life. I feel a sense of joy and purpose I've never felt before, and have relationships with people in positive trusting ways. Depression and anxiety are managed and life is manageable for the first time. I take better care of myself and have a more stable, balanced life--and fun! My husband sees a huge difference in me. This med has been a a game-changer after trying 9 other antidepressants with little luck. Who knew life could be do good? And no sexual side effects. It has been a life saver and I would do whatever I have to to stay on it.”

10 / 10
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Jay · Taken for 1 to 6 months December 20, 2019

“Excellent drug for my MDD/anxiety. Here's what I suggest: Start slowly. Cut a 5mg in half; let your body adjust for 4 days. Then go to 5 mg for 4 days. Then to 10mg. Stay on it. Let it do its work. It has dramatically lifted my depression and anxiety and has helped me enjoy life, interacting with friends, etc. It seems to hit all the right brain receptors for me. I went up to 20mg but didn't need it; 10mg was enough and there are less sexual side effects at 10mg. Low dose is enough to get my neurotransmitters functioning - no need to go higher. It might have taken me a little longer to get there due to the slower titration, but definitely worth it. Doc said to be patient and that climbing too high too fast will increase risk of nausea, etc. Since I didn't have that, I'm thinking he is right. Good luck, I hope it works for y'all like it has for me!”

10 / 10
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Thadius Watkins · Taken for 1 to 6 months February 13, 2019

“I've tried several other SSRI's for MDD. Lexapro had me puking every day. Prozac made me a zombie. Paxil gave me an energy boost and worked well, but developed severe sexual side effects. Cymbalta seemed to be the best, but I got into a really bad funk and it just wasn't enough. After entering into counselling once the depression became debilitating, my therapist had me follow up with a Psychiatrist. He switched me to Trintellix and it is hands down the best drug I've tried. No side effects. He also put me on 10mg Dexedrin 3x a day for ADHD which was previously untreated and the combination has been amazing. I told my wife it's like jogging your whole life with ankle and wrist weights on and then all of a sudden someone removes them. That's the mental change I've felt on this drug combination. My depression scores have reduced from about 20-30 to 2 as of today. I hesitate to use the term "miracle drug." But it has definitely been an answer to prayer.”

10 / 10
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Wicks · Taken for 1 to 6 months August 9, 2019

“I've been on every antidepressant known to man. Trintellix is the only one that I can say works for me. I have no nausea. Sex drive hasn't changed, still good. I am able to do my job now. I am happy for the first time in 20 years.”

10 / 10
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Trish · Taken for 6 months to 1 year February 25, 2020

“Been on a number of MDD medicines. This Trintellix is the best. It has changed my moods of depression to the better. I have tried others . It seem I had no energy, fatigued, and sat in the dark for a number of months . I was giving up on what would help me. I suffer from agorphobia as well as severe anxiety with panic disorder. Trintellix along with a low dose of at lorazepam has helped me cope and feel better. The company has been a blessing along with my doctor helping to pay for the trintellix. I would recommend!”

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feelinglow December 27, 2019

“Was on Cymbalta, dr put me on Trintellix 10mg. My depression was bad. All I wanted to do was stay in bed. I developed social anxiety. Wouldn’t go outside of my home. FINALLY I made a dr appt. My dr upped my dosage to 20mg. Feeling much better. I’ve only been on 2 weeks. I had not decorated for Christmas. I have 12 grandchildren who come to see us. We have a get together on Christmas Eve and it’s a big deal to them. I just didn’t care. After starting the 20mg it’s like something starting working again in my brain. I can’t explain it. I put my tree up, decorated it, decorated my house, went Christmas shopping, wrapped gifts and was ready when all my children and my grandchildren came over Christmas Eve. We had a wonderful time. It’s like I was ME again! I was wondering if anyone else has has good results with Trintellix and how soon. I’m hoping it’s not a placebo effect. I was crying all the time before she upped my dosage to 20mg. Now I feel good to go!”

10 / 10
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Zero January 13, 2020

“I used to believe in exerting strong mental control to handle depression without medication worrying it will last forever. But this time after multiple occasions acting suicidal behaviors I realized medication is a must. Dr gave me a few options incl trintellix asking me to research myself and let him know (I’ve been studying this on my own for quite a while and I actually appreciated this approach) I chose trintellix. Starting off 5mg for two weeks and going onto 10. Suicidal thoughts start to go down quite immediately. But I still feel quite depressed periodically. Until after 2 months or so, when I suddenly realize that I start to really be able to enjoy life the way I haven’t been able to for a long time. I have my innermost confidence back. And my sense of humor comes back too. I didn’t just count on the medication- I exercise my mental strength too during the period and try to exercise. I think combining all these it really helped. And trintellix works exactly as I hoped.”

10 / 10
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NoShaming August 8, 2019

“I switched from taking Trintellix at night to in the morning and it made a HUGE difference. I started taking this medication 3 months ago. During the first month I didn't notice any major changes in my mood and was experiencing horrible insomnia (which wasn't out of the norm). I was ready to give up on the medication because there was no real change. So I figured what's the point? Then I read somewhere that someone suggested switching to taking the Trintellix in the morning, so I tried that. I have noticed a MAJOR difference. This medicine really works. My mood is better, I can get through an 8 hour work day without any mood disruptions and perform regular chores when I get home. It has been years since I was able to perform a "regular" day with chores. Before, I couldn't get through an 8 hour work day. Now I feel great. Yes, I do still have bad moments, but they are nowhere near what they used to be. I feel good, I am sleeping good and I have lost some weight.”

10 / 10
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cocopebbles · Taken for 1 to 2 years April 11, 2019

“I wanted to wait a good amount of time being on this drug until I gave my review. I have now been on Trintellix for over 1 1/2 years and it works wonders for my depression. Prior to this medication I was on four different medications including: Cymbalta, Prozac, Wellbutrin and one other and none of them worked for me after a few months. This medication is for people who have serious depression and are looking for relief. I absolutely love this medication and it is the best I’ve ever been on.”

9 / 10
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mlovesd January 6, 2021

“I was on every drug in the book for depression, Prozac, Wellburtin, Pristiq, Cipralex, nothing took the edge off at all. Lost my mother to depression in July of 2019. Nothing could be worse. Was not on anything but Prozac at the time, and I wasn't doing well. Addicted to benzos, I was struggling. Doctor placed me on Trintellix, 10mg. Was kind enough to give me samples until I got coverage. Had a bit of a setback and fell into a depression six months later. Was boosted to 20mg and now I am doing fantastic. Depressive episodes do come back for a few days at a time but they are easier to handle if you get back in routine and force yourself. I think this is a great drug, I lost all hope in antidepressants previously.”

9 / 10
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Mike · Taken for 1 to 2 years July 12, 2019

“I have suffered from extended major depressive episodes for over 30 of my near 50 years and had very little real success at life. Since my first few months on Trintellix the clouds began to part for the very first time. I've been on the max dose, 20 mg per day, with 0 side effects and a whole new outlook on life. I've even taken on major projects that have led me to a new career and much happiness. There is a direct correlation between my starting this drug and feeling better.”

10 / 10
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Trintellsex · Taken for 1 to 2 years June 5, 2020

“Definitely mixed feelings about Trintellix after being on this medication for a year. Prior to this I took Paxil and abandoned that horror due to reduced emotions and feelings for anything or anyone. Began Trintellix and you'd swear I was bipolar (which I'm not). I wake up some mornings, take a 20 mg. tablet and feel happy, but severely anxious. Throughout the day the anxiety builds up until the evening. The evening sucks. The anxiety slowly builds into depression, wake up the next day and it happens all over again like groundhog day.”

4 / 10
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Honey · Taken for 2 to 5 years August 17, 2019

“I was diagnosed with Major Depressive Disorder and general anxiety after the birth of my first child who had a major birth defect causing 20 years of significant surgeries. I was put on zoloft which worked beautifully for over 22 years. It then began to wear off and I, too, was put on every anti-depression medication ever invented. Nothing ever worked. I continued to try everything, but eventually had a depression breakdown and lost my job of 35 years. Tried ECT, TMS but could not sustain the benefits as I had no medication working following the procedures. Finally was put on Trintellix (20 mg) with Bupropion and it is still working after 2 years. I pray this will continue to be effective as I will have no other hope if it does not. I experienced no adverse side effects. Not every med works for everyone as I am sure you have found out. Never give up hope!”

9 / 10
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MTC May 21, 2017

“So, back in the day I started with Wellburrin, Lexapro, Zoloft etc...tried it all and nothing was working. Finally my doctor switched me to Trentillex. There wasn't really any side effects when first starting. After about a month and a half, I finally felt something. The darkness went away. The despair, anxiety, and gripping hell that kept me from getting out of my own bed. It's all gone. As if it was lifted before my very own eyes. Life is great now. I'm truly happy for the first time in years. Please, give this a try, push through the side effects, and see what you feel like after 1-2 months. It's a small price to pay for a better life.”

10 / 10
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CD9 · Taken for less than 1 month December 26, 2019

“Huge difference with taking Trintellix in just a couple weeks. I have never responded well to antidepressants. It must get to the right receptors. First time I felt positive and hopeful for the future in over 10 years.”

9 / 10
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Trudy1910 · Taken for 1 to 6 months February 24, 2019

“I have taken almost all of the antidepressants with varying results but mainly side effects I couldn't tolerate for the past 25 years. I began taking Trintellix 3 months ago. Starting with 5 mg. It took away my appetite and I lost 10 lbs. Now, I am up to 20 mg. a day and am feeling better. My mood is up and I have more energy. The only side effect is a slight problem falling asleep and my appetite has returned. However, the good out weighs the bad and I am hopeful for the first time in many years.”

10 / 10
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Sam · Taken for less than 1 month January 1, 2021

“This medication Trintellix is the worst medication I have ever taken. I took it starting Nov 9 I only took it for 5 days before I ended up passing out on it. I started off at 5mg pills and during the time I took them I felt like I was high on speed. My pupils were wide, I was restless, paranoid, hallucinating, couldn’t sleep, zero appetite and nauseous. Eventually it all became too much and I passed out from one of the many severe panic attacks it gave me. The withdrawal even after only taking them for 5 days was terrifying. It felt like I was coming down off street drugs. It took almost 2 weeks to get back to myself!! Never again. Literally the worst nightmare of my entire life.”

1 / 10
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MicMac · Taken for 1 to 6 months October 11, 2018

“I’ve been on Trintellex for about 7 weeks now. I’ve gone from 5mg to 15mg and about to start 20mg. I’ve been on many antidepressant meds for over 25 years and nothing has helped like this medication has. I do get the extreme nausea (that’s why I didn’t give this med a 10 instead of a 9 rating), so I take this at night and sleep through the nausea side effect and no nausea during the day. It has helped me deal with my PTSD, MDD and anxiety. Now my house is clean, laundry is done, I take time for myself, react in a positive way instead of an emotional negative and defensive way, I have found with therapy and this med my world is changing and I no longer feel broken. My opinion is that it is definitely worth a try if nothing else has worked. This may just be the medication to put you back together again. The benefit of this med outweighs the side effects for me.”

9 / 10
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Whobeanie · Taken for 1 to 6 months May 25, 2019

“This stuff Trintellix is pretty close to a miracle for me. I have had terrible reactions to SSRI’s to the point where I was told to not try anymore. I went through 2 long depressive periods, the last for several months with almost constant suicidal thoughts. My anxiety was at a level that I was frozen and isolated. I tried the Dr one last time. He prescribed this at 5mg Trintellix and .50 klonpine 2x daily. Within one week, I was completely myself again. Myself in a way I hadn’t been in years. I don’t feel drugged just normal with normal anxiety in appropriate situations but that’s lowered. I have not gained a pound. There was no nausea for me. The only issue was it does make me sleepy so I take a few hours before bed. So happy to have found this, I would urge anyone with issues with older SSRI’s to give it a shot”

10 / 10
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LANIE · Taken for 1 to 6 months September 23, 2020

“I had severe nausea. I would take Trintellix every morning and within one hour after taking this medication I was vomiting severely. It went on for a couple of months and I had to be changed back to Lexapro! I was so disappointed, because it made feel better. Even after I would vomit, I was okay so in order to keep taking the medication I had to be put and take zofran every day. I didn't feel it was worth it so I switched back to Lexapro. Has Anyone else had these side affects. What should I do? Please help me out! Thanks”

1 / 10
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FigsMama · Taken for 1 to 6 months February 23, 2019

“I am updating my review of Trintellix. I have now been using it at 10 mg night for 5 weeks. Feeling better everyday. One thing I had a problem with is getting really sleepy early evening (around 5pm) so I started taking my dose at lunch time instead of first thing in the morning. That is working wonderfully for me. It has regulated my sleep patterns! Also a major plus is that it has helped me with my severe social anxiety. I am so happy that I was able walk into a fast food restaurant, order and sit and eat by myself! And enjoy it! I am 56 and never have done that before. I so hope this medication helps you friends and if not hope you find your happy place wherever it may be. Oh one more thing..the cost. I have Cigna insurance and of course they denied paying for this as it is a level 3 med. My Dr. was able to get me approved since I have failed on other AD’s and the copay was $60.00.”

10 / 10
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Bella May 11, 2019

“Prescribed 10 mg a day of Trintellix for depression and the first 10 days I was sick to my stomach and itching, so I take an antihistamine at the same time at bedtime. Day 11 started feeling markedly better, nausea was gone, still itching, but less. Day 14 my overall feeling was 50 percent better than when I started the drug. Today, day 16 saw my doctor again. I had lost weight, my overall anxiety is much better, the depression 70 percent better. All my aches and pains have disappeared. The doctor gave me 2 months of samples and told me to come back in a month if I thought I needed to, otherwise continue as directed. I've been on multiple anti depressants over the years, none worked even half as well as the Trintellix”

9 / 10
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Rae · Taken for 6 months to 1 year November 6, 2019

“I have noticed positive improvements in my mood and fatigue since switching from Effexor to Trintellix. I’m not terribly flatlined in my emotions (like with Effexor) but there are other side effects I’ve experienced. Nausea is a consistent side effect of Trintellix, and I typically get it 20ish minutes after taking my meds, and then it fades after a while. Also I’ve noticed appetite suppressing effects, which I’m not upset about, since I gained considerable weight on my last med. Overall I’m satisfied with Trintellix and would recommend it to someone who hasn’t done well on other antidepressants.”

7 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

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