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Trintellix for Major Depressive Disorder User Reviews

Trintellix has an average rating of 6.0 out of 10 from a total of 421 reviews for the treatment of Major Depressive Disorder. 49% of reviewers reported a positive experience, while 34% reported a negative experience.

Trintellix rating summary

6.0/10 average rating

421 ratings from 450 user reviews.

Compare all 56 medications used in the treatment of Major Depressive Disorder.

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Reviews for Trintellix

  • Pandora
  • Taken for 1 to 6 months
  • June 7, 2020

"I'm bipolar 2 and have suffered with major depression for so many years now. I have tried most antidepressants and with no luck! My latest bout lasted 3 very long years..3 very dark years. I had enough of fighting my own brain and decided that I should see my psychiatrist because I knew in my heart that this wouldn't get better and I would wake up in 3 more years worse and wondering where my life has gone. I did it and I've been on lamictal and trintellix for a few months now. I promise you it's the best result I have ever had. Zero side effects unless you go up in mg too fast. So far? I'm happier. I have more motivation. I have more clarity. I shower daily - most days lol And, more importantly, I have hope. Not all meds are meant for everyone and they are very different just we are as people. Please don't give up if trintellix isn't "Your drug" Blessings over you all, Pandora."

10 / 10
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  • bkc
  • Taken for less than 1 month
  • November 21, 2023

"I have had severe anxiety and depression. OCD and social anxiety... over 30 years. Trintellix has taken the edge off and allows me to relax and feel carefree. This is saying a lot because I was living between sadness and the terror of anxiety of the absolute worst kind. Trintellix has provided relief that I didn't think was possible. Thank you."

10 / 10
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57 Report
  • Jay
  • Taken for 1 to 6 months
  • December 20, 2019

"Excellent drug for my MDD/anxiety. Here's what I suggest: Start slowly. Cut a 5mg in half; let your body adjust for 4 days. Then go to 5 mg for 4 days. Then to 10mg. Stay on it. Let it do its work. It has dramatically lifted my depression and anxiety and has helped me enjoy life, interacting with friends, etc. It seems to hit all the right brain receptors for me. I went up to 20mg but didn't need it; 10mg was enough and there are less sexual side effects at 10mg. Low dose is enough to get my neurotransmitters functioning - no need to go higher. It might have taken me a little longer to get there due to the slower titration, but definitely worth it. Doc said to be patient and that climbing too high too fast will increase risk of nausea, etc. Since I didn't have that, I'm thinking he is right. Good luck, I hope it works for y'all like it has for me!"

10 / 10
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Frequently asked questions

  • Juliet
  • Taken for 6 months to 1 year
  • February 10, 2020

"Trintellix has changed my life. I feel a sense of joy and purpose I've never felt before, and have relationships with people in positive trusting ways. Depression and anxiety are managed and life is manageable for the first time. I take better care of myself and have a more stable, balanced life--and fun! My husband sees a huge difference in me. This med has been a a game-changer after trying 9 other antidepressants with little luck. Who knew life could be do good? And no sexual side effects. It has been a life saver and I would do whatever I have to to stay on it."

10 / 10
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  • Timukas
  • Taken for 6 months to 1 year
  • August 19, 2023

"I have depression and panic disorder. I have been sick since I was 14. Now I am 48 years old. I have tried almost every antidepressant in my life. Trintellix is the best I have found for myself. Don't be afraid to try and don't give up. You will find what will help you! Good luck."

9 / 10
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56 Report

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  • Wicks
  • Taken for 1 to 6 months
  • August 9, 2019

"I've been on every antidepressant known to man. Trintellix is the only one that I can say works for me. I have no nausea. Sex drive hasn't changed, still good. I am able to do my job now. I am happy for the first time in 20 years."

10 / 10
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227 Report
  • Thadius...
  • Taken for 1 to 6 months
  • February 13, 2019

"I've tried several other SSRI's for MDD. Lexapro had me puking every day. Prozac made me a zombie. Paxil gave me an energy boost and worked well, but developed severe sexual side effects. Cymbalta seemed to be the best, but I got into a really bad funk and it just wasn't enough. After entering into counselling once the depression became debilitating, my therapist had me follow up with a Psychiatrist. He switched me to Trintellix and it is hands down the best drug I've tried. No side effects. He also put me on 10mg Dexedrin 3x a day for ADHD which was previously untreated and the combination has been amazing. I told my wife it's like jogging your whole life with ankle and wrist weights on and then all of a sudden someone removes them. That's the mental change I've felt on this drug combination. My depression scores have reduced from about 20-30 to 2 as of today. I hesitate to use the term "miracle drug." But it has definitely been an answer to prayer."

10 / 10
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224 Report

More FAQ

  • feeli...
  • December 27, 2019

"Was on Cymbalta, dr put me on Trintellix 10mg. My depression was bad. All I wanted to do was stay in bed. I developed social anxiety. Wouldn’t go outside of my home. FINALLY I made a dr appt. My dr upped my dosage to 20mg. Feeling much better. I’ve only been on 2 weeks. I had not decorated for Christmas. I have 12 grandchildren who come to see us. We have a get together on Christmas Eve and it’s a big deal to them. I just didn’t care. After starting the 20mg it’s like something starting working again in my brain. I can’t explain it. I put my tree up, decorated it, decorated my house, went Christmas shopping, wrapped gifts and was ready when all my children and my grandchildren came over Christmas Eve. We had a wonderful time. It’s like I was ME again! I was wondering if anyone else has has good results with Trintellix and how soon. I’m hoping it’s not a placebo effect. I was crying all the time before she upped my dosage to 20mg. Now I feel good to go!"

10 / 10
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186 Report
  • Braxton
  • Taken for less than 1 month
  • October 5, 2020

"I have tried all the SSRI's and some SNRI's. literally, prozac, lexapro, citalopram, well butrin, amitriptyline, remeron, venlafaxine, pristiq, paxil. I had slight symptom relief with lexapro however, the side effects outweighed the benefit. I started on 5 mg of trintellix, I take it in the morning as it is a little stimulating for me, after the first week I went to 10 mgs. The only side effect I experienced is the nausea and that only lasted for about 4 days and it was not severe. I feel like a completely different person. If others have not worked for you give this one a try. It has given me my emotions and concentration back."

10 / 10
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148 Report
  • At Last
  • Taken for less than 1 month
  • February 6, 2023

"I have NEVER posted about a meditation. I had to with Trintellix. This drug literally brought me from a dark hole, back into the light. I’ve been through most medications, and started to feel hopeless. I am so happy I have it, and don’t care if I’m on it for the rest of my life. I’ve been depressed since age 11. I’m now 41. That plus years of anxiety was enough for me. Please give it a try. I started with 1/4 of the pill to introduce it into my system. I was so scared of the side effects, I’ve read about. Then I went up to 5 mg about 3 days later. I only need 1 soda cracker for nausea. Ginger ale helps too. If you are truly suffering, give this med a try!"

10 / 10
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  • Anony...
  • June 28, 2021

"I have been on 20 mg of trintellix for 6 weeks now, and it has helped me tremendously. Previously, I was on the maximum dose of sertraline for 2.5 years. It worked well, but I experienced a flattening of my emotions, low sex drive and restless leg syndrome. After a major bout of severe depression about 6 months after getting off sertraline, I tried lexapro but it made me sleep all day. My doctor suggested trintellix, and I've never been happier with an antidepressant. I noticed an increase in motivation after a week. At 4-5 weeks, I felt like myself when I'm well. I am (so far) not experiencing a single side effect. I had mild nausea at the beginning, but that's it. I know everyone's experiences with medication is highly individualized, but as a trauma survivor who does "everything right" (exercise, therapy, nutrition, etc) and still experiences severe depression, I am so grateful to have found trintellix. I will update this review if this changes."

10 / 10
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  • cocop...
  • Taken for 1 to 2 years
  • April 11, 2019

"I wanted to wait a good amount of time being on this drug until I gave my review. I have now been on Trintellix for over 1 1/2 years and it works wonders for my depression. Prior to this medication I was on four different medications including: Cymbalta, Prozac, Wellbutrin and one other and none of them worked for me after a few months. This medication is for people who have serious depression and are looking for relief. I absolutely love this medication and it is the best I’ve ever been on."

9 / 10
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  • NoSha...
  • August 8, 2019

"I switched from taking Trintellix at night to in the morning and it made a HUGE difference. I started taking this medication 3 months ago. During the first month I didn't notice any major changes in my mood and was experiencing horrible insomnia (which wasn't out of the norm). I was ready to give up on the medication because there was no real change. So I figured what's the point? Then I read somewhere that someone suggested switching to taking the Trintellix in the morning, so I tried that. I have noticed a MAJOR difference. This medicine really works. My mood is better, I can get through an 8 hour work day without any mood disruptions and perform regular chores when I get home. It has been years since I was able to perform a "regular" day with chores. Before, I couldn't get through an 8 hour work day. Now I feel great. Yes, I do still have bad moments, but they are nowhere near what they used to be. I feel good, I am sleeping good and I have lost some weight."

10 / 10
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141 Report
  • Mike
  • Taken for 1 to 2 years
  • July 12, 2019

"I have suffered from extended major depressive episodes for over 30 of my near 50 years and had very little real success at life. Since my first few months on Trintellix the clouds began to part for the very first time. I've been on the max dose, 20 mg per day, with 0 side effects and a whole new outlook on life. I've even taken on major projects that have led me to a new career and much happiness. There is a direct correlation between my starting this drug and feeling better."

10 / 10
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  • MTC
  • May 21, 2017

"So, back in the day I started with Wellburrin, Lexapro, Zoloft etc...tried it all and nothing was working. Finally my doctor switched me to Trentillex. There wasn't really any side effects when first starting. After about a month and a half, I finally felt something. The darkness went away. The despair, anxiety, and gripping hell that kept me from getting out of my own bed. It's all gone. As if it was lifted before my very own eyes. Life is great now. I'm truly happy for the first time in years. Please, give this a try, push through the side effects, and see what you feel like after 1-2 months. It's a small price to pay for a better life."

10 / 10
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179 Report
  • Zero
  • January 13, 2020

"I used to believe in exerting strong mental control to handle depression without medication worrying it will last forever. But this time after multiple occasions acting suicidal behaviors I realized medication is a must. Dr gave me a few options incl trintellix asking me to research myself and let him know (I’ve been studying this on my own for quite a while and I actually appreciated this approach) I chose trintellix. Starting off 5mg for two weeks and going onto 10. Suicidal thoughts start to go down quite immediately. But I still feel quite depressed periodically. Until after 2 months or so, when I suddenly realize that I start to really be able to enjoy life the way I haven’t been able to for a long time. I have my innermost confidence back. And my sense of humor comes back too. I didn’t just count on the medication- I exercise my mental strength too during the period and try to exercise. I think combining all these it really helped. And trintellix works exactly as I hoped."

10 / 10
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  • Trish
  • Taken for 6 months to 1 year
  • February 25, 2020

"Been on a number of MDD medicines. This Trintellix is the best. It has changed my moods of depression to the better. I have tried others . It seem I had no energy, fatigued, and sat in the dark for a number of months . I was giving up on what would help me. I suffer from agorphobia as well as severe anxiety with panic disorder. Trintellix along with a low dose of at lorazepam has helped me cope and feel better. The company has been a blessing along with my doctor helping to pay for the trintellix. I would recommend!"

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  • MicMac
  • Taken for 1 to 6 months
  • October 11, 2018

"I’ve been on Trintellex for about 7 weeks now. I’ve gone from 5mg to 15mg and about to start 20mg. I’ve been on many antidepressant meds for over 25 years and nothing has helped like this medication has. I do get the extreme nausea (that’s why I didn’t give this med a 10 instead of a 9 rating), so I take this at night and sleep through the nausea side effect and no nausea during the day. It has helped me deal with my PTSD, MDD and anxiety. Now my house is clean, laundry is done, I take time for myself, react in a positive way instead of an emotional negative and defensive way, I have found with therapy and this med my world is changing and I no longer feel broken. My opinion is that it is definitely worth a try if nothing else has worked. This may just be the medication to put you back together again. The benefit of this med outweighs the side effects for me."

9 / 10
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133 Report
  • Honey
  • Taken for 2 to 5 years
  • August 17, 2019

"I was diagnosed with Major Depressive Disorder and general anxiety after the birth of my first child who had a major birth defect causing 20 years of significant surgeries. I was put on zoloft which worked beautifully for over 22 years. It then began to wear off and I, too, was put on every anti-depression medication ever invented. Nothing ever worked. I continued to try everything, but eventually had a depression breakdown and lost my job of 35 years. Tried ECT, TMS but could not sustain the benefits as I had no medication working following the procedures. Finally was put on Trintellix (20 mg) with Bupropion and it is still working after 2 years. I pray this will continue to be effective as I will have no other hope if it does not. I experienced no adverse side effects. Not every med works for everyone as I am sure you have found out. Never give up hope!"

9 / 10
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  • Yay
  • Taken for 6 months to 1 year
  • September 26, 2023

"I tried different medications for around a year and a half, including most of the SSRI family, and some anticonvulsants and antipsychotics off-label. I have GAD and MDD. Trintellix was the only thing to finally work for me. It was a life saver. No side effects to speak of. I take 20mg. Manufacturer's coupon brings it down to only about $35 a month. So grateful I found this."

10 / 10
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  • Tim
  • March 24, 2023

"I’ve only been taking Trintellix for about 5 weeks and I can honestly say that this is the best emotionally that I have felt in years. I’d been taking Pristiq for almost 3 years and it simply was not working. Within a week of starting on Trintellix my mood, attitude, motivation overall well-being have improved 500%. I’m not having problems getting out of bed because I no longer dread the day ahead. My mass anxiety is just gone. I have energy and motivation and I’m once again taking initiative and taking ownership of my life and career. I’ve started doing light workouts again and eating right. This is exactly what I needed because I wasn’t on a good path. Now I’m totally looking forward to life as a grandpa (I’m 54), doing things that I’ve been avoiding and enjoying the ‘empty nest’ life with my wife!"

10 / 10
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  • Trudy
  • Taken for 1 to 6 months
  • February 24, 2019

"I have taken almost all of the antidepressants with varying results but mainly side effects I couldn't tolerate for the past 25 years. I began taking Trintellix 3 months ago. Starting with 5 mg. It took away my appetite and I lost 10 lbs. Now, I am up to 20 mg. a day and am feeling better. My mood is up and I have more energy. The only side effect is a slight problem falling asleep and my appetite has returned. However, the good out weighs the bad and I am hopeful for the first time in many years."

10 / 10
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  • Whobe...
  • Taken for 1 to 6 months
  • May 25, 2019

"This stuff Trintellix is pretty close to a miracle for me. I have had terrible reactions to SSRI’s to the point where I was told to not try anymore. I went through 2 long depressive periods, the last for several months with almost constant suicidal thoughts. My anxiety was at a level that I was frozen and isolated. I tried the Dr one last time. He prescribed this at 5mg Trintellix and .50 klonpine 2x daily. Within one week, I was completely myself again. Myself in a way I hadn’t been in years. I don’t feel drugged just normal with normal anxiety in appropriate situations but that’s lowered. I have not gained a pound. There was no nausea for me. The only issue was it does make me sleepy so I take a few hours before bed. So happy to have found this, I would urge anyone with issues with older SSRI’s to give it a shot"

10 / 10
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  • CD9
  • Taken for less than 1 month
  • December 26, 2019

"Huge difference with taking Trintellix in just a couple weeks. I have never responded well to antidepressants. It must get to the right receptors. First time I felt positive and hopeful for the future in over 10 years."

9 / 10
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95 Report
  • FigsM...
  • Taken for 1 to 6 months
  • February 23, 2019

"I am updating my review of Trintellix. I have now been using it at 10 mg night for 5 weeks. Feeling better everyday. One thing I had a problem with is getting really sleepy early evening (around 5pm) so I started taking my dose at lunch time instead of first thing in the morning. That is working wonderfully for me. It has regulated my sleep patterns! Also a major plus is that it has helped me with my severe social anxiety. I am so happy that I was able walk into a fast food restaurant, order and sit and eat by myself! And enjoy it! I am 56 and never have done that before. I so hope this medication helps you friends and if not hope you find your happy place wherever it may be. Oh one more thing..the cost. I have Cigna insurance and of course they denied paying for this as it is a level 3 med. My Dr. was able to get me approved since I have failed on other AD’s and the copay was $60.00."

10 / 10
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107 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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