Trintellix for Major Depressive Disorder User Reviews (Page 3)

• LAa...
• May 27, 2017

"Best (and most expensive) medication I've ever been on. I've been prescribed every other SSRI, and they gave me side effects of sleepiness and indifference. I have only experienced slight nausea for about 2 hours, 15 minutes after I take my Trintellix. This only lasted the first two weeks. The nausea is the only reason I give this a 9/10. Anxiety and paranoia have been greatly reduced, energy is amazing, and no sleepiness or indifference. I had genetic testing done, and I am deficient in folic acid and don't produce it on my own. I complement the Trintellix with methylfolate by Biotics Lab (Deplin is expensive). I'm happier than I've ever been, and no sexual dysfunctions have happened, so I am extremely thankful for this medication."

• Bea...
• June 19, 2016

"Have Major Depressive Disorder & PTSD. MAJOR ANXIETY DAILY. LIFE WAS UNBEARABLE. Trintellix 10mg has been a miracle for me. Haven't had suicidal thoughts, I'm able to work again. I can feel the real, happy me. I've also tried many other 'antidepressants' that didn't work well for me. THIS! by FAR, is the best. Worked quickly too. Good luck to all. Also, I am blessed to have the prescriber I do who specializes in PTSD."

• -Je...
• Taken for 1 to 6 months
• January 26, 2015

"I am bipolar and have major depression issues and have been on tons of meds, to the point where I have felt like a pin cushion for these meds. Either they make me so tired I can't do nothing or they just don't work. I started taking Brintellix 3 months ago and I am on 10 mg a day. Side effects, whether I took it with food or not I would throw up almost every day ugh... but on the upside it has made me feel like me again, not miserable and naggy looking at everything in a negative way! The nausea is still there sometimes in the morning but I will take it. So I can cope with everyday issues without freaking out and to be somewhat at peace with myself."

• Lil...
• Taken for 1 to 6 months
• September 3, 2018

"I've been diagnosed with double depression, which is a combo of persistent depressive disorder and major depression. I've been on so many medications that this med was my last shot before ECT. I can't believe the difference Trintellix has made in my life. I no longer have to worry about ECT, and I feel good for the first time in 17 years."

• Hap...
• Taken for less than 1 month
• January 9, 2018

"This medication has changed my life. For me, the cons are: I have energy to go, go, go, which I have never had. I feel happy for the first time ever. My panic attacks have completely stopped. I look forward to my future. I am so calm with everyone, where I was being very hateful and snappy before, and I am no longer afraid everyone is watching me every time I go in any public setting. I have not experienced any side effects. If you need a motivating, calming, make-you-feel-happy med, I suggest Trintellix. Diagnosis: PTSD, Major Depression Disorder, borderline personality disorder, OCD, and anxiety."

• Sta...
• August 15, 2019

"I have had MDD for over 10 years now, and I have been on Venlafaxine XR, Prozac, Cymbalta, and other medications. I have recently been switched to Trintellix because nothing else is helping. I tried to do yoga, Pilates, and daily exercise along with a keto diet. I read the other reviews, and I was very nervous before I started taking this. I thought this was not going to be a good medicine for me, but so far I have had zero side effects! I am on 10 mg for two weeks, and then I go to 20 mg. So we will see how long it takes to work out, but so far it’s not bad. I even got nausea meds just to be safe, but I have zero side effects! So that’s definitely a big plus! Other meds have made me gain 40 pounds and didn’t help. Every person is different, so I’m just trying to be a positive person based on my experience so far. Be safe and stay positive!"

• Mea...
• Taken for less than 1 month
• April 29, 2019

"I tried getting off of Effexor for a while, but withdrawals were bad. Lowering the dosage while increasing with Trintellix helped. 5 mg was fine. 10 mg was hard to get used to: nausea, diarrhea, really tired. I was also very itchy, but all of these symptoms went away after a week or two. One thing to note, I was a smoker and after a week of being on 10 mg, I can't stand smoking and quit. I also can't stand soda anymore. So, I am in love with this drug."

• Sie...
• June 12, 2019

"I have tried a few anti-depressants over the years since my 20s, like Celexa, Cymbalta, Lexapro (not good for me), Wellbutrin (not good for me in combination with Cymbalta), and now, Trintellix. I did the genetic testing after my experience on Trintellix and found that I have a genetic expression where my brain does not utilize serotonin very well due to fewer receptor sites (SSRIs are not good for me-it's the SLC6A4 gene if you are curious). Trintellix has a very high effect on serotonin receptor sites, so I did not do well on it at all. I had racing/hypo-manic thoughts, itching, higher appetite with food and sex, tinnitus, loose stools, insomnia, nausea, and very high energy. I would highly recommend doing the genetic test through your PCP or psychiatrist/nurse practitioner to determine your specific needs due to your specific genetics. Not every medication will work for everyone, and reviews can only tell us so much."

• Dig...
• Taken for 1 to 6 months
• September 12, 2015

"I had given up that there was any drug that could lift me out of the recurring cycles of clinical depression. I had tried dozens of medications over the years, some worked for a time but I came to the point that my depression was at least I thought untreatable. This last bout had me down in bed for nearly 2 months. I was 'blessed' to stumble upon Trintellix after my wife had recommended it after seeing it transform one of her patients. The key is it takes a very long time to work and you must be patient. I am now almost 6 weeks in and the depression has completely lifted and feeling better every day. Yes, there are side effects.. headaches, insomnia and confusion but they go away. This drug saved my life! Give it 6-8 weeks at minimum!"

• Jes...
• April 24, 2017

"It was very difficult titrating up to 20 mg of Trintellix. I started at 5 mg one week, 10 mg the next week, 15 mg the following week until I reached 20 mg. The nausea, vomiting, and dizziness were almost unbearable, I missed 2 days each week for a month while starting it. Thankfully I was on FMLA and was able to muscle through it. I have been through almost every SSRI, SNRI, etc., and nothing but electroconvulsive therapy worked for me. After the first week on Trintellix, I felt happy for the first time, actually happy, which is why I muscled through the side effects. I have been on it for a year now, and it is a miracle pill. Make it through the first month, and all side effects go away."

• Lad...
• Taken for 5 to 10 years
• November 24, 2024

"I have been taking Trintellix for about five years. I have been on so many antidepressants that I cannot count them all. Trintellix has worked the best for me and for the longest period of time. I have not had any of the side effects that are listed, and it has been beneficial for my sex drive. However, in the past two months, it has not been working as well. I've felt more down and depressed, and I had to add more sleeping meds to those I was already taking, as well as add more meds for my ADHD. My doctor is switching me to Viibryd (vilazodone) for a period of time to see if that will change things. The plan is to move back to Trintellix then. Overall, though, Trintellix is a medication I have tolerated well and one that has worked well for me over one of the longest time periods. When I was laid off from my job and my husband was only working part-time, the manufacturers of Trintellix had a program called 'Help a Hand,' which provided the meds free of charge for a year."

• Mik...
• September 20, 2016

"This medication has helped me so much! I tried Prozac, Zoloft, and Lexapro before starting this medication. I felt much better in about 3 days with Trintellix. It is so nice to have more focused energy and be able to function again at work as well as having fun with my kids again. Great medication!"

• Anonymous
• Taken for 2 to 5 years
• October 17, 2024

"I have ADHD, anxiety, and depression, and tried many different meds before Trintellix, but nothing really helped in a noticeable way. Trintellix makes the lows of my depression much more shallow and makes it much easier to keep on going instead of fixating on negatives! I use it along with Wellbutrin, which may make a difference. I'm just so glad I was able to find something that works!"

• NKO...
• January 25, 2016

"I've been on Trintellix now for 6 weeks. I started on 1/2 of a 5mg tablet because I hadn't tolerated any other SSRI. I increased to 5mg about 3 weeks ago. I've found a newfound hope in life. I had constipation, but increased my fiber intake, started on Benefiber daily, increased water consumption, and even had the desire to exercise, which also helps. I'm sold on this medication. I haven't felt this good in years!"

• Rav...
• Taken for 1 to 6 months
• October 19, 2019

"I've been on everything for depression, you name it: Zoloft, Prozac with add-ons like Buspar and/or mirtazapine, Abilify added to that mix, but nothing has worked till I tried Trintellix, and I do my extensive research since I study psychopharmacology. Anyway, this has been about 80% improvement. The only main side effect is a mild hypomania, or what I call a good mood and productive, and some jitteriness, like I'll have to pace sometimes. Helped my working memory, I can remember numbers better, but also events I can remember better."

• Jes...
• Taken for 1 to 6 months
• December 13, 2019

"I started taking this medication a little over 3 months ago after trying/failing to successfully taper myself off Lexapro. Lexapro was a great med for treating anxiety for several months, but when depression hit, Lexapro did not seem to be helping. My doctor had me switch to Trintellix, and I have been amazed at the result. Suicidal ideations are now small enough to ignore, and most of the time I can lift myself out of my down moods. I don't think 5 mg is quite enough, so I will be asking for 10 mg soon. If anyone is on the fence about this drug, I say give it a shot. I was really skeptical, and the first time my doc suggested it, I gave him a hard no in response. I finally tried it when he suggested it a second time, and I do not regret it. Also, my pharmacist found a really great discount coupon...I believe it was through the drug company itself."

• Can...
• March 11, 2019

"I'm a 25-year-old woman with major depressive disorder and social anxiety for 8 years (with episodes of agoraphobia). Trintellix solved my major depressive disorder in almost 3 weeks!!! I was very skeptical about the antidepressant meds, but this changed my view about it. I'm very happy with this antidepressant. I feel nauseated at times, but compared with the symptoms of depression, it's negligible. Of course, this is not a magic bullet, changes in your lifestyle are required: exercise, healthy food, no drinking or smoking... Hope this med helps you :)"

• Amb...
• Taken for 1 to 6 months
• June 20, 2025

"I have taken several antidepressants, all of which made me anxious and gave me insomnia. Found a new psychiatrist who started me on Trintellix. The first two weeks I felt great, no side effects except for feeling sedated. I welcomed it though because I no longer had panic attacks and felt really calm and neutral. After an increase from 5 to 10 mg I feel great. I still have feelings but I’m not sad or anxious. No sexual side effects. This medication really changed my life."

• Anonymous
• Taken for 6 months to 1 year
• August 3, 2015

"I am a 42-year-old mother. I have been depressed all of my life. Never been happy more than a few weeks at a time. I have tried a few different meds but no real change. I would also self-medicate with alcohol. At least once a week, I would get too drunk, I would black out. As you probably figured, that caused a lot of problems in itself. I started taking Trintellix 6 months ago, and I have NEVER been so happy in my entire life! I love it! It really changed my life for the better. No more drinking at all. I'm so happy, and my family has also seen the change and are more happy."

• Dir...
• Taken for 1 to 6 months
• April 29, 2019

"I have been on 10 mg Trintellix for nine weeks. I also take Risperidone and Buspirone. I was on Viibryd before I started this drug. I have had MDD for 24 years and have been on many antidepressants. Trintellix is by far the best I've been on. I had a little bit of nausea and vomiting, but really no side effects other than that. The side effects went away after the first three days. Trintellix has regulated my sleep and given me so much more energy and zest for life."

• ALM...
• Taken for 2 to 5 years
• February 20, 2016

"I am on 10mg of Trintellix, and have been for approximately 2 years. This med is a miracle worker for me. I am more stable than I have ever been. However, as a result, I experience severe nausea as well as projectile vomiting. If taken after a large meal, it is not as bad. Within the hour after taking the medication, I either feel like I am going to vomit or barely have time to make it to the toilet before vomiting. This is the one negative of this medication, so I have had to choose to deal with this in order to keep the positive outcome in dealing with my MDD. My whole life has changed since starting Trintellix. Vomiting and nausea are a small price compared to just not living."

• hap...
• October 31, 2014

"I have been depressed for 12 years. Throughout my life, I've contemplated suicide. I had paranoid thoughts and had very little self-esteem. I have been on and off multiple antidepressants and couldn't find one that made me feel like myself again. Finally, when I started to experience severe mood swings and found myself becoming angry for no reason to the people I loved, I decided I should try to get help once again. My doctor started me on Trintellix, and it has helped me so much. Fortunately, I don't experience any side effects. My mood is elevated, I'm gaining my confidence back, I'm more motivated, and most importantly, I feel like myself again. I'm taking 10mg currently and find no need to go to a higher dose. The only downfall is the cost."

• Jak...
• Taken for 2 to 5 years
• August 21, 2024

"I saw little to no effect for the first year. After 1 year, in addition to stoicism research and therapy, I began to notice a dramatic stability in my mind and reduced thoughts of suicide. If I miss more than 1 day of it now, I notice my mood dramatically drops, more towards anger than depression, though. I have had 1-2 weeks in the past of forgetting to take my pill, in which case my life began to completely fall apart. I love this drug sincerely and have come to accept that I may need to be on it for the rest of my life, no matter how much therapy or mental stability I have. It has given me stability I never thought I could obtain and has led me to living a very happy life ever since year 2 on the drug. The side effects I had in the first 1-2 years were an upset stomach and diarrhea if I didn't take it with a large meal. Now, 4-5 years later, I can eat it without a meal and feel perfectly fine. The primary side effect I still have is severely reduced sex drive."

• Anonymous
• Taken for 1 to 2 years
• July 2, 2016

"I've been taking this for over a year. Fortunately, I never experienced any of the side effects described by many people here. I always have such high hopes when trying something new for MDD. This medication did not deliver the hoped-for miracle of no more depression, but I must say, my mood has improved to a degree. I am able to get 'up' for certain activities now, where this was very difficult while on other medications. This has lightened my mood better than Viibryd or Cymbalta."

• 3rd...
• Taken for 2 to 5 years
• May 27, 2024

"Switching to this drug was easier than with other SSRIs as I did not have to wean for a month and then start this one. There was only a week of possible issues, but those were mitigated with a temporary medication. It does upset my stomach, even after 3 years on 10 mg, so I have to make sure I take it immediately after eating a good-sized meal. I also take Metamucil regularly due to the tendency toward constipation, although I do have IBS-C anyway. I have lately found it to be less effective than when I first started. There has been an increase in crying, racing thoughts, an increase in irritability, etc. My spouse notices within 24 hours if I have missed a dose due to personality changes. I will be addressing these issues with my doctor at my next scheduled visit. Drugs tend to become less effective with me over time in general, so I'm not sure if this is an issue with the drug itself or with my particular physiology."