Skip to Content

User Reviews for Bupropion

Also known as: Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion Forfivo XL Budeprion SR

Bupropion has an average rating of 7.1 out of 10 from a total of 2,265 ratings on 62% of those users who reviewed Bupropion reported a positive effect, while 19% reported a negative effect.

Condition Avg. Rating Reviews Compare
Depression   7.1
1177 reviews 81 medications
Major Depressive Disorder   7.0
312 reviews 47 medications
Smoking Cessation   8.1
287 reviews 18 medications
Anxiety  Off-label 5.9
139 reviews 53 medications
ADHD  Off-label 6.5
105 reviews 41 medications
Bipolar Disorder  Off-label 7.1
76 reviews 30 medications
Sexual Dysfunction, SSRI Induced  Off-label 6.8
73 reviews 15 medications
Obesity  Off-label 6.8
32 reviews 65 medications
Seasonal Affective Disorder   8.7
23 reviews 2 medications
Panic Disorder  Off-label 8.0
18 reviews 19 medications
Persistent Depressive Disorder  Off-label 7.6
13 reviews 3 medications
Postural Orthostatic Tachycardia Syndrome  Off-label 8.7
4 reviews 4 medications
Premenstrual Dysphoric Disorder  Off-label 8.7
4 reviews 50 medications
Migraine Prevention  Off-label 7.0
2 reviews 31 medications
Summary of Bupropion reviews 7.1 2,265 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Bupropion

Angela March 7, 2021

For Anxiety: “Bupropion is not intended for the treatment of anxiety disorders. Unlike sertraline or fluoxetine, bupropion acts on dopamine. Dopamine is not indicated in anxiety disorder. My doctor prescribed this medication off label for anxiety and my experience was very negative. Not only did bupropion not relieve symptoms of anxiety, it also caused severe nervousness and paranoia, high blood pressure, fast beating heart, constipation, difficulty concentrating, increased anxiety, not feeling alert, having trouble speaking, tremors, shaking, headaches, among other unpleasant side effects. Even though there are claims on the internet that bupropion is effective treatment for anxiety, it should never be given to individuals with anxiety. Bupropion is an antidepressant medication that blocks the reuptake of the neurotransmitter dopamine. Dopamine is not implicated in anxiety disorder such as panic disorder. Bupropion is intended for the treatment of depression, not anxiety.”

1 / 10
Jack · Taken for 1 to 6 months March 7, 2021

For Depression: “150MG XL. At first I felt more energy. This was good. Before I sat in place all day with no will to move. Now I was moving around more. It made me slightly anxious, nothing too bad. I figured if it can help my depression, I can put up with a bit of anxiety. The medication quickly lost the energy boost I initially received. At around the third week mark, the insomnia hit. I was only able to sleep every other night and only for 6 hours. I wanted so much to help my depression, I was willing to suffer though the insomnia, nightmares, and increasingly more anxiety during my many conscious hours. By week four I believe I was in some state of delirium. I was now falling asleep every night at midnight and waking up at 3am. No way to get back to sleep. One month in and back to the same depression. Six weeks and I was much worse than before the medication. I tapered down a few days and then stopped. Just so you know I wasn't taking anything else with this medication.”

1 / 10
Jess · Taken for 6 months to 1 year March 5, 2021

Wellbutrin (bupropion) for Depression: “Started Wellbutrin June of 2020. at first I was skeptical because I had tried zoloft and cipralex before it and they both didn't work. But Wellbutrin has done wonders for my confidence and happiness. First few weeks were pretty rough but then I started to feel better. I can honestly say that it has saved my life. Only side effects for me are teeth clenching at night, some ear ringing, and sometimes I feel like more anxious at times. But it is truly amazing for my depression.”

8 / 10
Max · Taken for 6 months to 1 year October 19, 2020

Wellbutrin XL (bupropion) for Depression: “Real and honest review. I’m a 52 yo male living in Canada. I’ve been suffering from Anxiety/ADD/Depression forever. I resisted and procrastinated to take meds again for “years” because of not so great experiences with SSRI’s but also because I read way too much online which scared me off. So I suffered for years until one really bad episode that forced me to take action. I asked my doc to give me Wellbutrin (Bupropion) since it had the least negative reviews (from my years of online self-help nonsense). Started 150mg of Wellbutrin XL for 3 weeks then 300 mg plus 10mg of Citalopram ever since . It’s been LIFE CHANGING really! It’s crazy how I can finally function like a normal human being. I swore to myself that I would write a review here if I found the remedy to my suffering, so here it is. Wellbutrin XL 300mg+10mg of Citalopram has worked “wonders” for me. No more Anxiety, very low ADD and NO MORE depression I really hope this helps a few of you out there.”

10 / 10
Lynn · Taken for 1 to 2 years March 19, 2019

For Obesity: “Bupropion saved my life, I was on it for weight lose !!!!!! I can not say enough great things about this. I had two babies, gained over 100 pounds and was trapped in this unknown body. Lost, sad and confused. My Dr gave me this prescription and literally changed my life. I was happier, filled with energy and lost 111 pounds. The absolute best best best thing ever !!!!”

10 / 10
Andi · Taken for 6 months to 1 year July 31, 2020

Wellbutrin (bupropion) for Major Depressive Disorder: “GIVE THIS MEDICATION WELLBUTRIN A FIGHTING CHANCE I almost quit a month in, but I am SO glad I didn’t and toughed out the negative side effects. When I started I felt dazed and sedated, but wired and jittery at the same time. My insomnia was horrible. Other side effects I experienced included tinnitus, horrible anxiety, hand tremors, heart palpitations, and a really short temper. I desired nothing, but had the energy to do everything - weird combo. OKAY, now for the GOOD, and things I think people should know before giving up this medication - the side effects last a LONG time (two and a half months for me), but they DO all go away. I was now able to get up early to workout, got into cooking, lost weight, and felt hopeful about life. Sex also got WAY better now that I could stop living in my head, which was a huge plus. For the first time in a long time I can really say I feel happy. So give it time!”

8 / 10
workitout (CONTRAVE) November 19, 2020

For Obesity: “Naltrexone hcl 50 mg 1/2 tab daily & Bupropion hcl er (SR)12hr 150 mg 1 tab daily for 14 days then 2 tab daily thereafter. I'm 5.6, 270 LBS with High blood pressure. Started 7 days ago. Right away 1st day the food, sugar, breads, starch cravings STOPPED. I feel so HAPPY to where I had to ask myself... Wait, was i still sad/depressed prior to taking these prescriptions. I didn't think I was so unhappy anymore, however according to the way I feel now with so much energy, wanting to socialize, engage in activities, date and create more than I ever had in the past. I question how much I locked up, put off in truly dealing with all the deaths in my family?. I have lost 13 pounds in the 1st 7 days!. DRY MOUTH (Side effects) which is a plus bcuz I now drank more water. I am so glad I took the leap and trusted myself to do this, I truly am looking forward to my tomorrows.Good luck on you journey's everyone.11/19/2020”

10 / 10
Cancer2Depression September 5, 2020

Wellbutrin (bupropion) for Depression: “I was a 250 pound fat and happy married man until I was diagnosed with stage 3B cancer. My wife and kids convinced me to see a Psych and get treated. Anyway, he started my on Wellbutrin (BUPROPION generic) at 200mg per day. He said this med has been around a long time and it's very safe and effective. Note that I don't have Anxiety. After a week on BUPROPION, I would sing on the way to work and was unable to take the smile off my face. After about 6 months these feelings wore off, but I was still better than before. My Psych upped the dosage to 300mg per day. I take two 100mg pills at 9am and then one 100mg pill at 230pm. Overall, I'm happy. It worked for me. Only side effects are a little insomnia twice per month and ringing in my ears 4 times per month, which lasts for hours each time. The ringing is very low. I get my meds Generic for a 90 day supply each time and my insurance charges me $24 for that 90 day supply (300mg/day).”

9 / 10
F/21 June 14, 2020

Wellbutrin (bupropion) for Major Depressive Disorder: “This drug Wellbutrin has been life changing for me. After trying SSRIs and SNRIs that didn’t work, it did the trick. Yes, it sucks at first; the side effects are horrible but you have to give it time. And on these meds at first, I got the head zaps, anxiety like I had never felt before, heart palpitations, lack of appetite and weight loss, headaches, nausea, severe insomnia- the whole nine yards. But after about 5 months on 300 mg, I turned a corner and feel better than ever. I can focus, I’m not tired but can sleep if I need to, my anxiety largely went away, I’m happy and can orgasm too. All the side effects pretty much subsided, save for the appetite one... I still don’t have to eat if I don’t want to but I’m not repulsed by the idea of food anymore. So seriously, it isn’t a conventional drug and it’s bad initially but PLEASE stick with it. Don’t expect it to work overnight... these things take time. I promise you will get results. You got this. Hang in there!”

10 / 10
Browntrout · Taken for 2 to 5 years February 27, 2020

Wellbutrin XL (bupropion) for Depression: “I always had a funk before I started taking Wellbuitrin. It was an underlining stress that I couldn't kick. It was hard to manage my stressful job and family. Wellbutrin has literally changed my life in so many positive ways. I manage stresses better, the feeling of a looming funk is gone and I've gotten really into running and lost a lot of weight. After about 2 years of being on Wellbutrin I slowly stopped taking it. After a few months of not being off of it I could feel familiar old feelings coming back. I've decided I like who I am better on Wellbutrin and started taking it again. Long story short I've very happy with this medication.”

10 / 10
AJ · Taken for 1 to 6 months August 6, 2020

Wellbutrin XL (bupropion) for Depression: “I took Wellbutrin XL for 6 months, the first 3 months my dose was 150mg, the last 3 months dose was 300mg. I was taking it for anxiety and depression. Took a little getting used to, but nothing terrible. In the 6 months I went from 150 lbs to 128 lbs (part of it was appetite-suppressant, part was that I had the energy to go out and do things/exercise). When I was at 150mg I had more anxiety attacks, but when I went to 300mg I felt like a normal human being (still having panic attacks, but they were due to being in a bad relationship). I loved this medication, only got off because I am now pregnant and didn’t want to worry about whether it was safe for the baby or not. Will be going back on once my baby is born.”

10 / 10
CJS · Taken for 1 to 2 years November 9, 2020

For Obesity: “I'm a 39 year old female. I've been on this medication for a bit over 1 year, I started at 150mg like most people do, then I went to 300mg and now I'm at 450mg. I used Wellbutrin (Bupropion) for anxiety and stress disorder along with depression. In 1 year I have lost 95.6 pounds (with not a lot of exercise but I do eat healthier) and I'm no longer obese. This drug works great for some and not so great for others. We all are different so the drug works different for everyone. As for me I'm very happy and so far no other side effects.”

10 / 10
happy · Taken for 6 months to 1 year July 25, 2020

For Obesity: “im 62 ys old wh male,pre diabetic ,I requested my primary care dr to put me on bupropion for weight loss, I've been on it a few months now and gone from 243 to 211 with no side effects except dry mouth. I hope I can avoid diabetes, it runs in my family. I'm worried about my hair thinning, if bupropion is causing that. Again I'm 62 and have had fine hair my entire life. Anyway covid19 will probably get me, that is not the way I expected to go out. Hopefully God will look over me and pass me by the COVID19. so far so good.”

10 / 10
TheTwizler · Taken for less than 1 month June 1, 2020

Wellbutrin (bupropion) for Depression: “I'm on day 3 of wellbutrin. So far it's been miserable. I'm on the lowest dose and still having horrible stomach side effects. I can't eat, I have no appetite, severe diarrhea with intense stomach pain. I'm also exhausted but can't seem to sleep more than a few hours at a time. My mouth is dry and my eyeballs feel like sandpaper. And to top it all off, just looking at my husband arouses me. I'd actually enjoy that side effect if I could stay off the toilet. I'm gonna try to stick it out in hopes that this will pass. I know I need to give it some time.”

Mariah August 22, 2020

For Anxiety: “I finally went on Wellbutrin after telling myself “I’ll try next year if it gets bad again”. This medication has eliminated my anxiety, encouraged more healthy habits, and brought me back into my body & stop self medicating for the first time in my life. This is NOT a cure-all! I have found that this medication must be paired with healthy habits (healthy diet of whole foods with plenty of fruits & veggies, ample hydration & sleep, etc.). Side effects I experienced in the first week included insomnia, mild constipation, thirst. All managed by previously stated healthy habits. After a couple weeks I stopped noticing any side effects at all. I’m about two months in and the drug is so affective I have been forgetting to take it. What anxiety?! If I could wave a magic wand I would make it so that this drug was effective for and available to every person with anxiety because it has changed my life.”

10 / 10
MLD112 · Taken for 1 to 6 months August 10, 2019

For Obesity: “My doctor prescribed me Wellbutrin/bupropion when my insurance wouldn’t cover Contrave. I have a hard time making good food choices when I always felt hungry, which has been since I had my son 3 years ago. The bupropion really suppresses my appetite and makes it easier to choose healthy foods. I am down 9 lbs in the first four weeks.”

Lo2150 May 21, 2019

For Obesity: “I was prescribed BUPROPION HCL SR 150 MG (once per day) for anxiety/depression as well as weight loss. Within days, it felt like the cloud had been lifted over my head, my mood was great & the FIRST DAY I took it, I noticed that I felt like I could eat and my brain and stomach knew when to stop. Even when I wanted to eat more, I just could not. In the beginning, I had to cut my breakfast/lunch/dinner servings in half and I was totally satisfied! I lost 10 pounds in the first 6 weeks. My advice is to keep a journal and track your progress! After 6 weeks, my doctor added TOPIRAMATE 50 MG TABLET 2 x per day. In 7 months I’ve lost 28 pounds, which is very exciting for me! Unfortunately, I’ve hit a plateau & the appetite suppression no longer seems to be working so, my doctor is increasing my dose BUPROPION 300 XL to see if this will help. I’m hopeful as I’ve had such success with it up until now! I’ll try to update my progress in a few months.”

9 / 10
Michigan Girl November 20, 2019

Wellbutrin XL (bupropion) for Depression: “I have been clinically depressed at various times in my life (postpartum and SAD) but have avoided medication for it. Recently I’ve been weepy, couldn’t get moving, and chores/phone calls/bills began piling up - No energy to deal with life. I talked to my GP who suggested Wellbutrin. I was hesitant but desperate to function again. It worked within a week. I am on 150 mg, XR. I was diagnosed with ADD as a young adult, and Wellbutrin is like the gentler, kinder version of Adderall. I have focus, can complete tasks, am happier. I have energy and willpower to exercise (instead of thinking about it all day and then feeling guilty for not doing it). I have less of an appetite, but not because I feel manically energetic/hyped up/shaky...Binging (which I did before) is not even a thought in my head. I’ve been on Wellbutrin for two and a half months, lost about 12 lbs. I would like to take Wellbutrin for the rest of my life - never felt this calm, even and steady, and capable.”

10 / 10
rasinsomniac · Taken for less than 1 month May 27, 2020

Wellbutrin (bupropion) for Depression: “After a break up with my girlfriend and one true love of my life I went to a really dark place and had serious suicidal thoughts. I was first put on Brintellix, then Valdoxan and three weeks ago to Wellbutrin. It's been six months since the break up and after using this med for 3 weeks I'm finally able to enjoy life again and have energy to get through the days with pleasure. This med has so far been a life safer for me. First two weeks were hard and I had serious insomnia but now for the first time in 6 months I don't need Ambien to sleep anymore. I seriously recommend this med, at least for me its working perfectly so far. Just give it time to start working and you will feel better.”

10 / 10
Pat1414 · Taken for 1 to 6 months May 10, 2020

Wellbutrin XL (bupropion) for Major Depressive Disorder: “This medication saved my life! I tried every different antidepressant. I was at my lowest and taking 2 antidepressants at the time. I never thought of suicide till then. I had nothing left, no hope, no joy. My Dr. prescribed 300mg Wellbutrin XL once a day and I kid you not, I WOKE UP A DIFFERENT PERSON! No depression, great mood, no anxiety (like some say), pleasure and joy back, no racing thoughts, no fatigue, no restlessness. I'm me again!”

Woody October 2, 2020

Wellbutrin (bupropion) for Depression: “I began Bupropion about a year ago. Took a while to kick in, Waiting eight weeks for the hoped-for effect was like waiting eight months. I had tried another med and it left me with negative sexual side effects which is why the doctor suggested Bupropion. I've been taking low dose Viagra, honestly don't know if I need it . . . but Viagra works. I told my doctor that I'm okay, but don't seem to feel any drastic change from when I first began the med. She suggested upping to 300 mg extended release. After a week I began to feel better but, don't know if it is from the med or the high of knowing I made the attempt at trying to feel better. Wishful thinking is a good way to put it. So here's my question: Since I was already taking Bupropion at 150 mg/day extended release should I expect the new dosage of 300 mg to take eight weeks to fully kick in? Has anyone had this experience?”

9 / 10
Boog · Taken for 6 months to 1 year January 6, 2020

Wellbutrin XL (bupropion) for Depression: “I've been on Wellbutrin XL 150mgs for about a year now and I've gotta say it's worked wonders for me. I was on Lexapro a few years ago and stopped taking it because the weight gain and zero sex drive was bringing me down. I wasn't taking any antidepressants for a year and a half and still couldn't lose the weight. My doctor put me on Wellbutrin, which I was nervous about at first because I also have generalized anxiety disorder and I read that it could exaggerate it. The first month I had splitting headaches and was only sleeping maybe 4-5 hours a night. Since then, things have obviously evened out, but it did take a few weeks. I feel great now, I'm energetic and passionate about things I haven't been in years. I started at 168lbs and have lost 30 pounds; I'm officially down to my pre-lexapro weight. I'm so glad that this medicine works for me, it's made such a huge difference in my day to day!”

10 / 10
Anonymous · Taken for 1 to 2 years February 6, 2021

Wellbutrin XL (bupropion) for Depression: “I've tried almost every other selective reuptake Inhibitor and a few different tricyclic antidepressants for moderate depression and severe anxiety. This Wellbutrin XL is the first one that hasn't increased my anxiety and has actually helped. Currently on 450mg extended release.”

9 / 10
MJ February 6, 2021

Wellbutrin XL (bupropion) for Depression: “I was diagnosed with Bipolar II and C-PTSD in 2015. I tried a handful of different medications, but I was also dependent on alcohol. I stopped drinking August 2020 and soon after went med-free (supervised) to see where I was at. What appeared to come about was depression mostly. When I started 150mg buproprion HCL XL, within 48 hrs I felt more energy, more activated emotions, less fog. It caused me to be more agitated and angry at first, but I knew it was because I was coming from complete numbness to actually having some feelings. I am now a month in and I feel happy about where I am with my mood. I say definitely give it a chance, especially if you are not a fan of SSRIs. Give it a few weeks and log your feelings. Being on this is far better than where I was in my depression. I wanted to share my experience and feelings because it has given me some hope and I want to share that with others.”

8 / 10
Kai2277 October 10, 2018

Wellbutrin (bupropion) for Depression: “I had an odd situation where I was not really depressed with sadness but I just felt nothing. I never got angry, never got happy- never wanted to do anything besides lay in bed. I tried to fake it as much as possible but I couldn’t anymore. I stopped answering my phone, lost all interest and motivation. I had taken all the antidepressants on the market but they made me feel crazy. My hands shook and I felt out of my body. I started researching the symptoms of low dopamine and I had almost all of the symptoms- poor memory, poor concentration, excessive worrying, lack of motivation- and overall just not giving a $#|+ about anything. I asked my doctor for Wellbutrin. In a couple of days I was calling old friends, kicking butt at work, and motivated for life again. My problem all along was dopamine not serotonin. I am thankful I figured it out. DON'T GIVE UP. Read about brain chemicals- dopamine, serotonin, and, norephenephrine- and make the choice based on research.”

10 / 10
Katt · Taken for 6 months to 1 year June 26, 2019

For Obesity: “I was originally prescribed 300mg wellbutrin XR as a true antidepressant. I have managed to completely stop smoking and I've lost over 20 pounds in about 6 months of taking my medication. I have seen most of the weight drop in the past couple of months. My only complaint is the headaches in the beginning for about a month. Tylenol knocked those out quickly though.”

9 / 10
Leigh · Taken for 1 to 6 months January 2, 2021

Wellbutrin (bupropion) for Depression: “When I tried an SSRI I ended up lying on the floor almost unresponsive. I won't take one again. In the last year my depression and anxiety got really bad. Horrible panic attacks, slamming doors, screaming, irritability... then came the suicidal thoughts. My doctor suggested Wellbutrin. I have a very sensitive body so I started on 75 mg once a day. Man. I noticed a difference within the first day or two. The third day I woke up with tons of energy and unpacked my suitcase that had been sitting in my closet for a week, before I even started working! Unheard of for me. My outlook on life has improved, I don't snap at my husband, I don't get annoyed. Plus I've lost 4 lbs and my sex drive has increased slightly. The only side effects I've had were the brain "zingers" people talk about (they have subsided) and pretty bad insomnia. I'm hoping the insomnia goes away, but right now the positives definitely outweigh the negatives! A world of difference!”

9 / 10
Salim April 26, 2020

Wellbutrin (bupropion) for Major Depressive Disorder: “Wellbutrin was amazing to me I was on it for depression, but I stopped smoking after I used to smoke a lot a day. It gave me enormous energy and improved my depression a lot. I am thankful to the scientists who developed this drug. Don't let the negative reviews scare you. Try it and you will not regret it”

10 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.