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Bupropion for Major Depressive Disorder User Reviews

Brand names: Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion Forfivo XL Budeprion SR

Bupropion has an average rating of 6.9 out of 10 from a total of 400 reviews for the treatment of Major Depressive Disorder. 60% of reviewers reported a positive experience, while 23% reported a negative experience.

Bupropion rating summary

6.9/10 average rating

400 ratings from 422 user reviews.

Compare all 56 medications used in the treatment of Major Depressive Disorder.

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Reviews for Bupropion

  • alive
  • Taken for 2 to 5 years
  • March 20, 2021

Wellbutrin (bupropion) "Like others on this site, I have tried so many antidepressants. SSRIs take away any sexual feeling for me, and I tend to put on weight and not have the best self-image with them. Bupropion is the only medication that really allows me to feel my feelings, and talk more easily in social settings. After your adjustment (some insomnia for a few weeks) it actually helped me to sleep better. It took me a few times of trying this medication to really get it to work for me. It helped with my anxiety rather than making it worse, but depression was my biggest problem: hopelessness, fatigue, etc. This medication makes jokes funny, trees prettier, and makes me feel emotionally stronger. Remember that it takes courage and patience to get help and to stick with it until it works. God bless."

10 / 10
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1285 Report
  • Andi
  • Taken for 6 months to 1 year
  • July 31, 2020

Wellbutrin (bupropion) "Give this medication Wellbutrin a fighting chance. I almost quit a month in, but I am SO glad I didn’t and toughed out the negative side effects. When I started, I felt dazed and sedated but wired and jittery at the same time. My insomnia was horrible. Other side effects I experienced included tinnitus, horrible anxiety, hand tremors, heart palpitations, and a really short temper. I desired nothing, but had the energy to do everything - weird combo. OKAY, now for the GOOD, and things I think people should know before giving up this medication - the side effects last a LONG time (two and a half months for me) but they DO all go away. I was now able to get up early to work out, got into cooking, lost weight, and felt hopeful about life. Sex also got WAY better now that I could stop living in my head, which was a huge plus. For the first time in a long time, I can really say I feel happy. So give it time!"

8 / 10
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  • F21
  • June 14, 2020

Wellbutrin (bupropion) "This drug Wellbutrin has been life-changing for me. After trying SSRIs and SNRIs that didn’t work, it did the trick. Yes, it sucks at first; the side effects are horrible, but you have to give it time. And on these meds at first, I got the head zaps, anxiety like I had never felt before, heart palpitations, lack of appetite and weight loss, headaches, nausea, severe insomnia - the whole nine yards. But after about 5 months on 300 mg, I turned a corner and feel better than ever. I can focus, I’m not tired but can sleep if I need to, my anxiety largely went away, I’m happy and can orgasm too. All the side effects pretty much subsided, save for the appetite one... I still don’t have to eat if I don’t want to, but I’m not repulsed by the idea of food anymore. So seriously, it isn’t a conventional drug and it’s bad initially, but PLEASE stick with it. Don’t expect it to work overnight... these things take time. I promise you will get results. You got this. Hang in there!"

10 / 10
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Frequently asked questions

  • Pat
  • Taken for 1 to 6 months
  • May 10, 2020

Wellbutrin XL (bupropion) "This medication saved my life! I tried every different antidepressant. I was at my lowest and taking 2 antidepressants at the time. I never thought of suicide till then. I had nothing left, no hope, no joy. My Dr. prescribed 300mg Wellbutrin XL once a day, and I kid you not, I WOKE UP A DIFFERENT PERSON! No depression, great mood, no anxiety (like some say), pleasure and joy back, no racing thoughts, no fatigue, no restlessness. I'm me again!"

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  • Salim
  • April 26, 2020

Wellbutrin (bupropion) "Wellbutrin was amazing to me. I was on it for depression, but I stopped smoking after. I used to smoke a lot a day. It gave me enormous energy and improved my depression a lot. I am thankful to the scientists who developed this drug. Don't let the negative reviews scare you. Try it and you will not regret it."

10 / 10
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333 Report

Are you taking this medicine?

  • Lin-Lu
  • January 10, 2017

Wellbutrin XL (bupropion) "I have been on and off different SSRI's and none of them have helped, e.g., slept my life away, foggy mind, couldn't concentrate, no feelings, constant ringing in my ears, low libido. I started on Wellbutrin XL 150mg for 1 month and my doc upped my dose to 300mg. My experience has been super wonderful, from sleeping too much I am now going to bed later at night and getting up earlier & feel refreshed. I cry when I need to which to me is a good release. I am always busy. I have redone my whole home & garden, I go out more (used to be a total recluse). I sit & have my coffee out on the patio & watch the bird life and find so much joy in everyday life. I have found an inner peace with Wellbutrin XL that I have never felt before. Big thumbs up :)"

10 / 10
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  • Carol...
  • Taken for 10 years or more
  • May 10, 2021

Wellbutrin SR (bupropion) "I have been on Wellbutrin SR almost since it was available for use by the FDA. I started on the starter dose of 100 mg Wellbutrin SR. I felt much better. Then my MD wanted me to try the next size increase, so I did. I had a bad reaction of paranoia, so I went back down to my starting dose. I have been on that dose ever since. With this medication, I went from sleeping 14-18 hours, thinking nonstop about everything negative, to sleeping an average of 8 hrs with NO ruminating about negative thoughts. I went back to school and became an RN. I am an example of a huge success story on Wellbutrin. Before I started on Wellbutrin, I had tried all the other antidepressants on the market, with no success."

10 / 10
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159 Report
  • David...
  • March 27, 2016

Wellbutrin (bupropion) "I really did not intend to review Wellbutrin... just curious what other people said... but so much 'neg' I felt I had to speak. I've been on it for 29 YEARS! I had been seriously depressed for a few months.. my therapist was a moron for waiting three months to send me to a psych! I was told it would take at least 2 weeks to be really effective... for me it was day 17. I woke up and when I first looked in the mirror (gut check time), I didn't say to myself 'wow I feel better', I said 'omg is this what normal people feel like when they wake up in the morning?' For all practical purposes, that was like my actual birthday... the day I became a fully functioning human. I'm lucky, it works and it keeps working."

10 / 10
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  • Bug
  • Taken for 1 to 6 months
  • July 22, 2019

Wellbutrin SR (bupropion) "Wellbutrin saved my life. I was at the point that I hated being around everyone. I could only manage to go to work and come back to my bed. I had no energy. I had no sex drive. I had no interest in ANYTHING. I wasn't sad...I just existed. I endured feeling like this for about a year. No breaks of feeling better. My doctor prescribed me Wellbutrin SR and it has changed my life. The first week was hard. The side effects were no joke. I had minor auditory and visual hallucinations and experienced my first panic attack of my life. BUT - my doctor asked me to push through it and I did. It has helped me quit smoking. I have lost 15 pounds and I am not lethargic anymore. It boosted my libido. I can be around people without wanting to flip out. I can concentrate at work again. I sleep 7-8 hours like most people. Instead of spending every moment I can in bed. If this is an option - I highly recommend Wellbutrin."

10 / 10
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  • Joy
  • Taken for 1 to 6 months
  • September 2, 2020

Wellbutrin (bupropion) "I’m 39 female that was prescribed Wellbutrin/Bupropion without a psych evaluation and soon as I started taking it... I began having dreams and sexual desires. I continued thinking things would change but they got worse. Weeks later I began to hallucinate and even forgot where I parked my car after going shopping one day and ended up calling police and reported it stolen when it wasn’t. I also started seeing things that weren’t there and having really dark thoughts. This drug took over my life and caused me to make irrational decisions like up and moving 1200 miles across country for no apparent reason whatsoever. A situation I regret! I got a second opinion and was taken off of wellbutrin immediately and given a psych evaluation. I was given prozac and trazadone but no longer take them. I just got a puppy, I changed my diet and lifestyle and learned coping mechanisms. I will never take another pill if I can help it."

1 / 10
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139 Report
  • Vice
  • February 13, 2020

Wellbutrin (bupropion) "Wellbutrin has changed my life! I was such a terrible, irrational, and very depressed person before this medication. My partner and I were always arguing, mostly due to my own fault. I had such a hard time getting out of bed and taking on the day. I would absolutely need a mid-afternoon four-hour nap to get me through. Wellbutrin has given me so much mental clarity. It has saved my relationship and allowed me to go through my days feeling 'normal'. The only downfall is it gives me a very dry mouth, which is not good for my overall oral health, but I have found some toothpaste and mouthwash that help a little. It's worth it for the clear mind."

9 / 10
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  • dani
  • Taken for 6 months to 1 year
  • November 21, 2023

Wellbutrin XL (bupropion) "I was depressed for 9 years with sudden onset at 17 that was so severe I got it while eating only healthy with lots of protein and going to the gym 5-6 times a week while having the time of my life socially. Immediately, I knew it's not environmental so I started seeing psychiatrists. I was started on Zoloft, which helped partially but stopped working (made me bipolar-like). After Zoloft, I tried a lot of garbage like paroxetine, escitalopram, fluvoxetine, lamotrigine, seroquel, abilify, modafinil, duloxetine (even tried ordering Parnate from the black market but it got seized). The list goes on. Eventually, I begged my psychiatrist for bupropion and lo and behold, 1 week in, cured. From daily suicidal thoughts for 9 years to NONE. And no sexual side effects like others, only 150mg does it for me, no side effects at all. On 300mg, I get irritable and get amphetamine-like side effects (jaw grinding), so more does not equal better. This is my first review and hopefully my last (at least for depression regimen)."

10 / 10
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  • Becker
  • Taken for less than 1 month
  • September 28, 2019

Wellbutrin (bupropion) "Hardly any side effects. Had a little nausea for the first few nights but that’s all. I’ve noticed a HUGE difference in my anxiety and depression. I’m better at work. I don’t get worked up when I’m overloaded with work. I take 150mg XL at 8:30 am and there’s no weird coming down feeling at night. It’s a beautiful medication. I couldn’t stop watching TV and now I can turn it off and do dishes, laundry, take my dog on a hike. I don’t have that gut-wrenching anxiety knot in my stomach anymore."

10 / 10
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142 Report
  • ASDFG
  • Taken for 5 to 10 years
  • August 22, 2020

Wellbutrin (bupropion) "This Wellbutrin is the only antidepressant I can tolerate. It seems to be one of the more stimulating ones, which I need because of my hypothyroidism. I can't handle a high dose, so I have stuck with 100-150mg 1x a day for over 5 years, and I don't usually feel depressed. If I miss a dose, I feel a little down and lethargic. I've smoked on and off for 20+ years, and I can't say it helps me in that area--at least not at the dose I'm taking. I've been told I am wired differently than most (O-) and so far, this is the only mostly effective antidepressant I have ever taken without side effects."

9 / 10
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  • Jay...
  • Taken for 2 to 5 years
  • April 13, 2023

Wellbutrin (bupropion) "Took this years ago and it helped. Made the rookie mistake of stopping the meds because I felt I didn’t need them anymore. But duh that means they were working. When I stopped I got suicidal. Back on for two weeks now and it’s like a fog has been lifted. No real side effects. Just better thoughts and outlook on life. Can’t believe I stopped my meds before. Never again."

10 / 10
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  • Sharon
  • Taken for 2 to 5 years
  • May 26, 2020

Wellbutrin XL (bupropion) "I have been taking Wellbutrin 300 XL for about 3 years. It helps my depression a lot. I am able to function daily and not overreact. Started at 150 mg and went to 300 mg. Before Wellbutrin, I was very depressed, and working, parenting, and everything was causing me grief, sadness, and fear. I was overweight and I overreacted to small things. I felt hopeless and on edge every day. I have a low-functioning thyroid as well that may have been making my depression worse. So now I am on track. It took me about 2 weeks to feel a difference. Now I do have several of the side effects. I lost about 30 lbs. I have a low appetite, I have ringing in my right ear. I also have dry mouth, anxiety, trouble sleeping, and blurred vision. I can handle the side effects but not the depression. So I have stayed on the medicine. Also, I suddenly stopped taking the meds one time and it caused suicidal thoughts and flu-like symptoms."

8 / 10
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  • DDano
  • Taken for 2 to 5 years
  • November 13, 2019

Wellbutrin XL (bupropion) "My first antidepressant when I turned 22. Currently taking 150mg XL once a day. It definitely felt like a super drug for the first few months: happier mood, increased motivation, less food binging, happier sex life. Wellbutrin XL will eventually slow down in terms of effectiveness. But even without the 'high' energy, I am in a better place with it. Don't do this - I stopped taking them to see if I still needed them, and that was a good laugh. No physical withdrawals, but my suicidal thoughts came back. So I learned to just be humble and accept a life with *at least* no suicidal thoughts."

9 / 10
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  • senio...
  • Taken for 1 to 6 months
  • April 9, 2024

Wellbutrin (bupropion) "I was on a low and had no energy and was self-medicating with alcohol. I was always in bed, no energy, just blah! Crying all the time, missing work. I decided to seek help, and my doctor put me on this med a month ago. All I can say is wow!! I've not been stressed and worrying about every little thing. I have no urge to drink at all, and I'm able to get out and do stuff with my kids. Depression sucks, but I'm glad this med is working for me."

10 / 10
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  • Niki9...
  • Taken for 1 to 2 years
  • October 27, 2014

Wellbutrin (bupropion) "I have Major Depressive Disorder, Post Traumatic Stress Disorder. I've taken Zoloft, Paxil, Citalopram. I'm currently taking Wellbutrin 300XL, Cipralex 25mg. Cipralex only got me out of suicidal thoughts, but Wellbutrin healed my brain. When my psychiatrist first prescribed it to me, I couldn't afford it, so I didn't fill my prescription. When she found out, she gave me some samples. Within a week, I got motivation. I had forgotten how it felt to want to do things. My thoughts were more cheerful. I was able to laugh and joke. My PTSD paranoia went down. I began walking, quit smoking, went back to work, traveled, and met the love of my life. It made me me again! I'm still taking it and will for as long as my brain needs it."

10 / 10
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  • Lyla...
  • June 17, 2014

Wellbutrin XL (bupropion) "I was diagnosed with major depressive disorder in 2006. My depression comes in cycles, but I take this medication every day. I was on Zoloft for about 3 years off and on and gained about 30 pounds, was tired all the time, and had some discouraging sexual side effects to top everything off. I did my research and discovered Wellbutrin, which other people said was more stimulating and had no sexual side effects. I asked my doctor if I could switch and started tapering off Zoloft while starting 150 mg of Wellbutrin. My doctor upped the dose to 300 mg and I had never been happier! It has drastically changed my life. Lost weight and can get up in the morning without being a total grouch. I only gave it a 9 because of the cost."

9 / 10
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  • Birds...
  • Taken for 5 to 10 years
  • April 6, 2020

Wellbutrin (bupropion) "I’ve been on Wellbutrin XL with my dosage varying from 300-450. This is the best antidepressant I have ever tried, and I have tried many. Whenever I increase my dosage, I do experience side effects for a little while. Mostly, I’m more easily annoyed and fidgety. They always go away over time. This is the only medication that has been able to increase my energy levels and sex drive. I also have GAD, have had psychotic depression in the past, and panic attacks in the past. This drug doesn’t exacerbate any of those problems for me. I’m also on Seroquel though, so that probably helps with my sleep. Many antidepressants have given me terrible headaches, but this one does not. I get migraines a few times a year, same as before. If you’ve found that other antidepressants don’t work for you, I highly recommend this one. Almost no side effects and definitely gives me the energy I need."

10 / 10
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100 Report
  • RhettV
  • July 6, 2017

Wellbutrin (bupropion) "I've been on Wellbutrin for about three months now. It was prescribed to me by a psychiatrist due to depression and anxiety, low cognitive function, and bad working memory. Wellbutrin started working on me around week 8. Mood lifted immensely, better executive function, lower anxiety, became much more goal-oriented. Stopped delaying and procrastinating everything, became interested in my hobbies again, felt clear-headed, more energetic, and general mental well-being. Struggle with working memory a bit, still."

10 / 10
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  • Monica
  • Taken for 1 to 6 months
  • September 23, 2019

Wellbutrin (bupropion) "Wellbutrin has been amazing. I have anxiety, depression, ADHD & PTSD. It was hard getting used to this one as it amped me up a lot. Take with food as early as possible. The constipation and anxiety did subside. Now I can’t believe I’ve allowed myself to be so sad when this stuff even makes air blowing on my face feel incredible. Here’s what I found - after trying everything SSRI wise, if you have bad side effects right away, it’s not the right drug. Taking this Wellbutrin, I knew right away, was totally different. I did need Xanax to be a crutch with this at first because of the anxiety...but I was also tapering off gabapentin at the time so who knows why I was that anxious. So this is how “normal” people feel w/o depression...interesting. Lucky."

10 / 10
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  • JosieS
  • Taken for 1 to 6 months
  • August 14, 2023

Wellbutrin XL (bupropion) "Before: I've lived with depression for at least 10 years. I've tried Lexapro, Paxil, and Prozac in the past, unfortunately, it left me overall numb. I felt antidepressants weren't for me, so I tried overcoming my depression by changing my lifestyle. For a year, I ate healthier, worked out, and got enough sleep. While my overall health did improve (based on my bloodwork), and I did feel a bit better, my depression was still hovering over me like a cloud. I was still down, had crying spells, snapping at people, bouts of anger, irritable, and just had zero patience. I knew I had to do something when I couldn't even enjoy my vacation at a beautiful resort. Present: My doctor prescribed me Wellbutrin XL 150 mg, and oddly enough, I started to feel better after 3 days. Two weeks in, my husband noticed I was more focused, calmer, happier, and overall uplifted. 2 months in, I feel like a different person. Please give Wellbutrin a try, you have nothing to lose."

10 / 10
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  • Aano
  • Taken for less than 1 month
  • December 20, 2019

Wellbutrin XL (bupropion) "I’ve been taking this for a little over 2 weeks now. Before this I was on Zoloft for almost 5 years. 6 years of my life I had constant thoughts of ending it. Ever since I’ve been on this medication I finally want to live. So far I’m having the basic side effects of most anti depressants, loss of appetite (although it is coming back), dry mouth, constipation/stomach pains, and being a bit more sensitive than usual. I would much rather deal with any side effects than wanting to end my life. I’ve read that some side effects will go away within time (since I’m only on my third week)"

9 / 10
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95 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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