Generic Name: bupropion (byoo PRO pee on)
Brand Names: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL
What is Zyban?
Zyban (bupropion) is used to help people stop smoking by reducing cravings and other withdrawal effects.
Bupropion may also be used for purposes not listed in this medication guide.
You should not take Zyban if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.
Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Zyban may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Zyban. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Before taking this medicine
Do not use Zyban if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You should not take Zyban if you are allergic to bupropion, or if you have:
epilepsy or a seizure disorder;
an eating disorder such as anorexia or bulimia; or
if you have suddenly stopped using alcohol, seizure medication, or a sedative (Valium, Nembutal, Seconal, Solfoton, and others).
Zyban may cause seizures, especially in people with certain medical conditions. Tell your doctor about all of your medical conditions.
Do not take bupropion to treat more than one condition at a time. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.
To make sure this medicine is safe for you, tell your doctor if you have:
a history of head injury, seizures, or brain or spinal cord tumor;
heart disease, high blood pressure, history of heart attack;
kidney or liver disease (especially cirrhosis); or
bipolar disorder (manic depression).
It is not known whether bupropion will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Zyban?
Take Zyban exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure.
When you start taking Zyban you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.
Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatment. Read all directions and safety information for the nicotine product. Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects.
You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.
Smoking cessation may also cause new or worsening mental health problems, such as depression.
You should not change your dose or stop using this medicine suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms.
This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion.
Store at room temperature away from moisture and heat.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.
What should I avoid while taking Zyban?
Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Zyban can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.
Zyban may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Zyban side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Zyban: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You may have changes in thinking or behavior while taking Zyban to help you quit smoking. If you have any of the following symptoms, stop taking this medicine and call your doctor right away:
mood or behavior changes, unusual thoughts or feelings;
feeling anxious, restless, or depressed;
agitation, hostility, aggression;
impulsive or risk-taking behavior;
confusion, paranoia, hallucinations, panic; or
thoughts about suicide or hurting yourself.
Report any new or worsening symptoms to your doctor.
Call your doctor at once if you have:
a seizure (convulsions);
a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
severe skin reactionfever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Zyban side effects may include:
dry mouth, nausea, stomach pain;
headache, dizziness, ringing in your ears;
loss of interest in sex;
sore throat, muscle pain;
mild itching or skin rash, increased sweating, increased urination; or
changes in appetite, weight loss or gain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Zyban dosing information
Usual Adult Dose for Smoking Cessation:
Initial Dose: 150 mg orally once a day.
Maintenance: Based on clinical response, this dosage may be increased to 300 mg/day, given as 150 mg twice a day, no sooner than 3 days after beginning therapy.
What other drugs will affect Zyban?
You may have a higher risk of seizures if you use certain other medicines while taking Zyban.
Many drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Zyban. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Zyban (bupropion)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- 73 Reviews – Add your own review/rating
- Generic Availability
- Drug class: smoking cessation agents
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Zyban.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zyban only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2017 Cerner Multum, Inc. Version: 19.01. Revision Date: 2016-12-28, 8:52:13 PM.