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User Reviews for Trintellix

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Major Depressive Disorder 182 reviews 46 medications
   
6.4
Depression 321 reviews 79 medications
   
6.1
Summary of Trintellix reviews 503 reviews 6.2

Reviews for Trintellix

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For Depression "Took 5 mg on a Friday, it put me to sleep for 12 hours. Took another 5 mg the next day and my chest seized up and my left arm lost sensation. I then started having heart arrhythmia every minute to the point where my entire left side of my chest hurt. I had no energy for the entire weekend. I felt depressed and miserable and in pain. I tried one more time Sunday night before bed and it woke me up from a dead sleep with chest pain and arrhythmia. I still have chest pain and arrhythmia and I've been off of it for 1 week. My energy levels are still low and I get out of breath easily. I have never had any problems cardio wise in the past."

   
1.0

Sogilu September 19, 2017

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For Major Depressive Disorder "For me this has been the worse medicine in the world. I took it four days and thought I would be crazy. I hate going to the hospital but I couldn't handle it any longer. Wow I felt so depressed, so sad, terrible but my friend told me stop this medicine and drink hot tea black tea. I did four times wow I felt another person ,"

   
1.0

NILDA Sendra September 18, 2017

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For Depression "I started at a 1/4 dose (2.5mg) and couldn't make it past day 6. I didn't have the vomiting that others report, but it destroyed my appetite. And then gave me diarrhea. Fastest 5lbs I ever lost. But moreover, it felt like I'd taken a bad amphetamine. It made me INCREDIBLY anxious; heart racing; waking at 5AM in a panic. I've taken SSRI's before--this was something more/different. There were a few glimmers around day 5 when I felt my mood was better (kind of like the kick you get from a cup of coffee) but the rest was unmanageable."

   
3.0

Markus2017 September 18, 2017

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For Depression "I took this from Feb 2017 until Sept 2017 for my GAD. I alternated between 5mg & 10mg daily. It worked ok for my anxiety, but just ok. Sex drive non-existent. Gained 20 lbs with no other lifestyle changes, so it had to be this medicine. I stopped with no withdrawal symptoms so that's good."

   
3.0

RedHairGirl (taken for 6 months to 1 year) September 15, 2017

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For Major Depressive Disorder "I have been on various medications such as Lexapro, Zoloft, and most recently Pristiq for two years, which worked wonders but I was no longer getting full benefits. So I asked my doctor if we could try something new. He recommended Trintellix. The first time I started taking it, my stomach hurt, like bloating, so I stopped and continued with the Pristiq. Went back to Dr and he told me to slowly ween off Pristiq while taking small dosage of Trintelix to give my body time to adjust. 1/2 Pristiq and 1/2 5mg Trintelix for 1wk, then 1/2 Pristiq every other day, and 5mg Trintelix for one week, then no pristiq and 7.5mg Trintelix for one week, and finally to goal of 10mg Trintelix. This worked much better and reduced the stomach aches."

SKato1 September 9, 2017

4 users found this comment helpful.

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For Major Depressive Disorder "This medication helped a little in the beginning, but then made me worse over time. With each increase dose the doctor insisted I'd start feeling better. By the time we got to 15 mg, I wasn't sleeping, I was having peripheral hallucinations, and emotional outbursts. I tried to tell my psychiatrist, but he seemed too invested in keeping his patients on this med. So I went to see my primary, who knows me well. I was an emotional wreck. I told him I had already dosed the med back down to 10 mg. He told me to come off the drug and gave me something for sleep. Perhaps there are people this med really helps, but it made everything in my life so much worse. So I fired my psychiatrist and will be seeing a new one soon"

   
1.0

Sushi33 (taken for 6 months to 1 year) September 7, 2017

8 users found this comment helpful.

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For Major Depressive Disorder "I've been on Trintellix 20 mg x 10 months, 53-year-old female with long-standing, chronic MDD & anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times & in my 30's, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses, or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; hasn't been a "miracle" drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, & 10 mg Adderall daily."

   
7.0

Tracy1124 (taken for 6 months to 1 year) September 6, 2017

17 users found this comment helpful.

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For Depression "I've been on Trintellix for 7 weeks along with Buspirone for Anxiety, which is my biggest problem. About 1 month in on Trintellix I got hives and itchy skin too. Wasn't sure what that was about. The hives seem to be going away slowly, not all gone yet but the itchy skin remains. It's manageable, just annoying. Not really sure this medication is helping me. Right now just trying to get/keep the anxiety under control."

   
5.0

Daisy Jeanne (taken for 1 to 6 months) September 5, 2017

7 users found this comment helpful.

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For Depression "This pill makes me so nauseated and ill feeling that there is no way this should have ever been cleared by the FDA. After 2 months of taking it to let it "kick in" I feel like I'm physically dying. I've taken other anti-depressants that were fine. This should be recalled immediately."

   
2.0

JimDiesel (taken for 1 to 6 months) September 3, 2017

16 users found this comment helpful.

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For Major Depressive Disorder "I have taken Lexapro for depression and anxiety for over 10 years-beginning in my early 40's. I have tried to change to other medications without success. But, I had the side effects on Lexapro of tiredness, lack of energy, and apathy. Maybe related to those side effects, but I believe also separately, I gained a lot of weight since I started the medicine. The trintellix is the first medicine that not is working on my mood and anxiety and my energy and get up and go has returned. I feel 20 years younger! For the past 6 weeks, I have taken 10 mg of Trinellix, while titration slowly down on my Lexapro (had been at 30 mg for years). I was less than hopeful, but am so thrilled to have this successs finally. I do have some stomach upset-not ba"

   
9.0

ozzycookie (taken for 1 to 6 months) September 3, 2017

10 users found this comment helpful.

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For Major Depressive Disorder "Terrible drug. Was so nauseated every day for 6 weeks until switched to zoloft or prozac."

   
1.0

Anonymous (taken for 1 to 6 months) September 1, 2017

7 users found this comment helpful.

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For Major Depressive Disorder "I'm not allergic to anything except this drug. It made my body turn red, was painful, and gave me bumps all over my body that looked like measles which lasted for months before going away. I only took this medication for 3 days."

   
1.0

Anonymous (taken for less than 1 month) August 31, 2017

3 users found this comment helpful.

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For Major Depressive Disorder "I was prescribed 10 mg, but used a pill cutter to cut the pills in half to start the treatment slowly. Of note, I was off of Citalopram for 6 weeks prior to starting this new medication. After taking the first dose, I awoke the next day with heightened ringing in my ears (aka tinnitus). I took the dose at night and felt hungry after doing so. After only 6 days, and consulting my pdoc, I stopped dosing as the tinnitus did not stop and I'm concerned about damaging my hearing. 6 days after taking the last dose, I'm still experiencing nausea, general malaise, and the tinnitus is still there. The drug has a long half life. I had high hopes for this medication, and am really disappointed. I have to see an ENT about the tinnitus as well."

BJ1097 (taken for less than 1 month) August 30, 2017

6 users found this comment helpful.

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For Depression "Minimal effectiveness for me. Was on 10 mg for anxiety and depression for 8 months. Had to reduce to 5 mg due to extreme fatigue and general malaise. When my Dr. asked if it was helping I said I didn't know, other than it was making me tired and emotionless (not happy, not sad). His reply was if you don't know then it's not doing anything, Good answer! I tapered off over 2 months and withdrawal was hell. Now am only taking clonazapam for anxiety and feel much better. Tried it again for 1.5 weeks and only 5 mg (just to be sure) and had same extreme fatigue, blah blah blah feeling, and felt down and worthless. Then withdrawal effects again after only such a short period. This drug is not for me."

   
2.0

pvisser42 (taken for 6 months to 1 year) August 29, 2017

13 users found this comment helpful.

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For Major Depressive Disorder "I have severe depression and have been on Trintellix for a month. At first, the nausea and vomiting were awful. My doctor gave me promethizine, but that didn't help. A medication that did work is Zofran, and it works like a charm for the nausea. It completely stops it. I take Trintellix in afternoon and about an hour later, Zofran. No more nausea; I am so relieved. However, I thought Trintellix would help my depression more. I seem to be more anxious. I am prescribed Valium 5 mg. up to once a day, but I rarely used to take it. Now I am so anxious that I have to take it. I was so hopeful, and now I'm so disappointed that Trintellix is not working as expected. Does anyone have any suggestions for another anti-depressant?"

   
6.0

Dreamer528 (taken for 1 to 6 months) August 26, 2017

11 users found this comment helpful.

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For Depression "Have been on Trintellix 10 mg for 3 months now. Previously tried Celexa and Lexapro, and years ago Paxil and Prozac. Overall, it definitely works well to control my anxiety. My problems were more anxiety than depression, although Trintellix seems to help with my mood as well. I'm not nearly as tired as I was on Celexa and Lexapro. No nausea, but I still have some sexual side effects (low libido). Although the sexual side effects are definitely better than Celexa or Lexapro. Overall though, probably the best of the antidepressants I've been on, comparing efficacy vs. side effects."

   
7.0

Dc1331 August 23, 2017

25 users found this comment helpful.

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For Depression "Been on 10mg trintellex for 9 days after weening off Zoloft 150mg over a month Really feel much better on trintellex but I have itchy skin and hives. I got hives on one side of face the first day now they move around . Take hydroxizine which has helped some Going to stop trintellex and start back on Zoloft to see if hives go away per Dr suggestion. Has anyone else gotten hives and do they go away over time. If I knew they would go away I would stick with it a little longer"

   
10

Flowersrule August 17, 2017

13 users found this comment helpful.

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For Depression "Trintellix (30 mg) has helped manage my depression but has resulted in exceptional weight gain. I have gained 30 lb in 9 months, which just adds to the depression and self disgust."

   
5.0

GSD 521 August 15, 2017

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For Depression "Been on this medication for about 6 months now. I didn't have any start up side effects which has always been an issue with me. Been on so many different antidepressants with no good results. I'm no longer sad and I honestly think I'm in a good place in my life. Added in 100mg of wellbutrin SR for energy since the trintellix didn't give me that boost. Only complaint is I have muscle spasmsmore frequently and this medication hasn't helped with my G.A.D. Some days I'll have to take an anti anxiety pill but not very often. I got the savings card and only pay $10 for this which is nice."

Lo Marie August 14, 2017

15 users found this comment helpful.

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For Depression "I am 59 year old woman - I had bizarre dreams every night and I also suffered severe muscle spasms on Trintellix."

   
1.0

Anonymous (taken for 1 to 6 months) August 11, 2017

13 users found this comment helpful.

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For Major Depressive Disorder "I've been on pretty much every antidepressant. SSRI's do nothing for my depression. The only other medication that helped was Wellbutrin, but I stopped that due to not being able to sleep at all. I started on 5 mg then increased to 10 mg 2 weeks later. It has helped my depression the most and I have more energy. The side effects are what make me hate taking this. I've experienced nausea, vomiting, constipation, and decreased sexual desire. The worst though is the nausea. I'm nauseous every time I take it, doesn't matter if I eat with it or not. If I don't eat before I take it then I vomit. This medication is also expensive, it's not covered by my insurance."

   
6.0

AshN101 August 6, 2017

13 users found this comment helpful.

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For Depression "My doctor gave me samples. Went from Zoloft to Trintellix. Let's just say, this has not been a good experience. I have a tough stomach but everytime I take this medicine I'm to the point of vomiting. Tried taking it before bed, definitely not a good idea either. Up vomiting too. I did see a small boost in energy though.. but with all the sickness, I would have to say taking this is not worth it."

   
3.0

Thatgirl789 (taken for less than 1 month) August 1, 2017

22 users found this comment helpful.

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For Depression "The medication worked well for 6 months with no sexual side effects. However, after that, I have noticed that Trintellix not effective as used to be and I dealt with low libido. Once I stopped the medication, my sexual desire was back. Overall, the medication deserves a trial especially if your insurance covers it. Good luck every one."

   
7.0

Abdul0120 (taken for 1 to 2 years) July 30, 2017

15 users found this comment helpful.

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For Depression "I have generalized anxiety disorder with a hint of depression. I started out on 5mg of brintillix along with buspar and klonopin, then after 2 weeks I went up to 10 mg of trintillix. I take the medicine in the morning and within 10 mins I'm having severe abdominal pains, dry heaving , migraines, and itching everywhere!!!! I've been on klonopin for years so I know it's not that. Buspar makes me feel crazy so only thing It could be is the trintillix. I just assume stop rather than take anymore and feel this much physical pain. It will make you crazy in itself. I do not recommend this to anyone."

Janafaye (taken for less than 1 month) July 30, 2017

17 users found this comment helpful.

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For Depression "I was prescribed this medication for anxiety I am going on almost 8 weeks now and really starting to feel better not 100% sure if it's the meds or that I cut back my working hours but I feel pretty good! I did have migraines and nausea when I first started but I toughed it out if you can tough out the side affects it will get better !"

Anonymous (taken for 1 to 6 months) July 26, 2017

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