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Trintellix Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix Vraylar Wellbutrin XL
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix (vortioxetine) Vraylar (cariprazine) Wellbutrin XL (bupropion)
Prescription only

Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more

Prescription only

Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to... View more

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

More about Trintellix (vortioxetine) More about Vraylar (cariprazine) More about Wellbutrin XL (bupropion)
Ratings & Reviews

Trintellix has an average rating of 6.0 out of 10 from a total of 1108 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 33% reported a negative effect.

Vraylar has an average rating of 5.8 out of 10 from a total of 483 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 36% reported a negative effect.

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 486 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 15% reported a negative effect.

View all 1108 reviews

View all 483 reviews

View all 486 reviews

Drug Class
Side Effects

See also: Trintellix side effects in more detail.

See also: Vraylar side effects in more detail.

See also: Wellbutrin XL side effects in more detail.
Generic Availability

No lower cost generic approved

No lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 30 tablet
Dosage 5 mg
Per Unit* $17.50
Cost* $525.12

View all Trintellix prices

Quantity 20 each
Dosage 1.5 mg
Per Unit* $51.25
Cost* $1,024.98

View all Vraylar prices

Quantity 30 tablet, extended release
Dosage 150 mg/24 hours
Per Unit* $70.42
Cost* $2,112.52

View all Wellbutrin XL prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available
  • Oral tablet
  • Oral capsule
  • Oral tablet, extended release
Brand Names

N/A

N/A

 Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

66 hours

504 hours

30 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 352 drugs are known to interact with Trintellix:

  • 95 major drug interactions (438 brand and generic names)
  • 256 moderate drug interactions (1011 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 569 drugs are known to interact with Vraylar:

  • 93 major drug interactions (380 brand and generic names)
  • 475 moderate drug interactions (1806 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 502 drugs are known to interact with Wellbutrin XL:

  • 218 major drug interactions (955 brand and generic names)
  • 279 moderate drug interactions (1287 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more
  • Grapefruit juice can increase the blood levels of cariprazine. This may increase side effects such... View more
  • Using cariprazine together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
First Approval Date

September 30, 2013

September 17, 2015

August 28, 2003
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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