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Trintellix Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix Bupropion Cymbalta
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix (vortioxetine) Bupropion Cymbalta (duloxetine)
Prescription only

Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

More about Trintellix (vortioxetine) More about Bupropion More about Cymbalta (duloxetine)
Generic Status

No lower-cost generic available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Trintellix has an average rating of 5.9 out of 10 from a total of 1055 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect.

Bupropion has an average rating of 7.0 out of 10 from a total of 2748 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 21% reported a negative effect.

Cymbalta has an average rating of 6.2 out of 10 from a total of 1826 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 1055 reviews

View all 2748 reviews

View all 1826 reviews

Drug Class
Side Effects

Common side effects include:

  • diarrhea
  • male sexual disorder
  • nausea

See also: Trintellix side effects in more detail.

Commonly reported side effects include:

  • insomnia
  • nausea
  • pharyngitis
  • weight loss
  • constipation
  • dizziness
  • headache
  • xerostomia

See also: bupropion side effects in more detail.

Common side effects include:

  • asthenia
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • fatigue
  • hypersomnia
  • insomnia
  • nausea
  • sedated state
  • headache
  • xerostomia
  • show all 12

See also: Cymbalta side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 30 tablet
Dosage 5 mg
Per Unit* $16.69
Cost* $500.57

View all Trintellix prices

Quantity 30 each
Dosage 150 mg/24 hours
Per Unit* $1.51
Cost* $45.27

View all bupropion prices

Quantity 30 delayed release capsule
Dosage 60 mg
Per Unit* $10.16
Cost* $304.87

View all Cymbalta prices and generic prices

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Dosage Form(s) Available
  • Oral tablet
  • Oral tablet
  • Oral tablet, extended release
  • Oral delayed release capsule
Brand Names

N/A

 Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL Other duloxetine brands include: Drizalma Sprinkle, Irenka
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

66 hours

30 hours

17 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 340 drugs are known to interact with Trintellix:

  • 92 major drug interactions (429 brand and generic names)
  • 247 moderate drug interactions (970 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 485 drugs are known to interact with bupropion:

  • 216 major drug interactions (942 brand and generic names)
  • 264 moderate drug interactions (1240 brand and generic names)
  • 5 minor drug interactions (17 brand and generic names)

A total of 578 drugs are known to interact with Cymbalta:

  • 104 major drug interactions (459 brand and generic names)
  • 451 moderate drug interactions (1963 brand and generic names)
  • 23 minor drug interactions (182 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
Disease Interactions
First Approval Date

September 30, 2013

August 30, 2012

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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