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Trintellix Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix (vortioxetine) Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trintellix (vortioxetine) Rexulti (brexpiprazole) Wellbutrin XL (bupropion)
Prescription only

Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

More about Trintellix (vortioxetine) More about Rexulti (brexpiprazole) More about Wellbutrin XL (bupropion)
Ratings & Reviews

Trintellix has an average rating of 6.0 out of 10 from a total of 1129 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 32% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 490 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect.

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect.

View all 1129 reviews

View all 490 reviews

View all 492 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Trintellix side effects

View all Rexulti side effects

View all Wellbutrin XL side effects
Drug Class
Generic Availability

No lower cost generic approved

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 30 tablet
Strength 5 mg
Per unit* $18.63
Cost* $558.87

View all Trintellix prices

Quantity 30 tablet
Strength 0.25 mg
Per unit* $54.27
Cost* $1,628.03

View all Rexulti prices

Quantity 30 tablet, extended release
Strength 150 mg/24 hours
Per unit* $78.44
Cost* $2,353.09

View all Wellbutrin XL prices

Get free Discount Card

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Dosage Forms
  • Oral tablet
  • Oral tablet
  • Oral tablet, extended release
Brand Names

N/A

N/A

 Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

66 hours

91 hours

30 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 354 drugs are known to interact with Trintellix:

  • 95 major drug interactions (440 brand and generic names)
  • 258 moderate drug interactions (1025 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 600 drugs are known to interact with Rexulti:

  • 136 major drug interactions (610 brand and generic names)
  • 461 moderate drug interactions (1715 brand and generic names)
  • 3 minor drug interactions (9 brand and generic names)

A total of 559 drugs are known to interact with Wellbutrin XL:

  • 218 major drug interactions (951 brand and generic names)
  • 336 moderate drug interactions (1872 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of vortioxetine such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
Disease Interactions
First Approval Date

September 30, 2013

July 10, 2015

August 28, 2003
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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