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User Reviews for Zoloft

Zoloft has an average rating of 7.2 out of 10 from a total of 1,589 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect.

Condition Avg. Rating Reviews Compare
Depression  
6.8
580 reviews 78 medications
Panic Disorder  
7.4
313 reviews 19 medications
Social Anxiety Disorder  
7.4
269 reviews 6 medications
Obsessive Compulsive Disorder  
7.9
127 reviews 11 medications
Major Depressive Disorder  
6.6
116 reviews 47 medications
Post Traumatic Stress Disorder  
6.6
92 reviews 5 medications
Premenstrual Dysphoric Disorder  
7.8
47 reviews 50 medications
Postpartum Depression  
8.2
45 reviews 8 medications
Summary of Zoloft reviews 7.2 1,589 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Zoloft

Saved_MyLife September 9, 2019

For Depression: “I’m 36 and I’ve dealt with depression my entire life. I was also irritable. It would come, hit me hard, and then go away. I thought diets, sleep etc could help me. They would only at first. I gave Lexapro a try, my first medication ever. It helped some and I wanted to “settle” with Lexapro because at least my depression was at bay Two years ago I started Zoloft and it literally saved my life, marriage, memories with my kids, saved me from me. I truly didn’t know what normal life was like until I started Zoloft. It hasn’t changed me, it helped me be the true, happy me that would show up periodically. All those “organic” ways might help some people. Just don’t think “big pharma” can’t help you, like I did before I tried meds. I never ever ever thought I would be saying that. For two years now I’ve been alive, I’ve run my business like never before; I’m patient with my kids, my wife, my family. I hope so badly this review helps someone out there who is just like I was.”

10 / 10
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lil July 2, 2021

For Depression: “hi guys, I promised I would come back and leave a review after trying zoloft. I am female (21) and I have been diagnosed with depression, anxiety, and post traumatic stress disorder from a car crash. I read SO many reviews talking about their horrible crazy experiences so I was super scared to try this. I’m on 25mg of zoloft daily which I believe is the lowest dose. It has worked wonders for me. PLEASE GIVE IT A TRY. The first night I took it without food and I was up all night extremely nauseous with a crazy amount of energy. definitely take it in the morning. The only annoying side effects I've experienced are mild nausea if i take it without food and lower libido. This pill has changed my life and honestly saved my life. I am so much more productive and energetic, I no longer have racing thoughts and cry for hours every night. I feel like myself again, and I feel like my best self. I wish you all the best luck on your journey. You are so loved !!!!”

9 / 10
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JMM February 7, 2020

For Depression: “2 mths ago I was desperately going through these pages to find something positive about sertraline My had mother died and my daughter, 3 weeks after, went into treatment for 6 weeks for anorexia. Long story short, I had an acute panic/anxiety/depression event in early December. I started on Zoloft 25mg on Dec 11. I had most hours of feeling 'ok' but I was frustrated that I was still feeling that adrenalin and anxiety. By week 5 I was still frustrated by feelings of anxiety. Then everything lifted. I promise you will feel better. I absolutely promise. Stick with it. But do the work too! Go out! Exercise! Eat well! (I had no appetite!) Don't watch the news. Look for the small things. And read or listen to Claire Weekes on you tube (it's like your grandma giving you a talking to) xxx You will be better x”

9 / 10
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2020 · Taken for 1 to 6 months January 14, 2020

For Depression: “Hello, I have been taking Sertraline for almost two months and I give it 10 out of 10, I feel amazing! In addition to taking the medication, I created my own healing plan: drink water, 8 hour sleep, cognitive behaviour therapy, cut off alcohol, caffeine and sugar, eat vegetables, fish, fruits and nuts, exercise 3 times a week, take vitamin D, B12, magnesium, spend time with friends and family, enjoy the sun, do something fun, meditate and do yoga (try these apps: Calm and Headspace). There is also a free app called Flow which help you to treat depression, have a reiki session and let go what is not making you happy (job, relationships, addiction), etc. Medication is great but you need to look at other aspects of your life as well to heal :-)”

10 / 10
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Dom June 8, 2020

For Panic Disorder: “I suffered from panic attacks back in 2017 I was terrified of going on medication But I was sad all the time, I felt empty. After my panic attacks came depression. No one understood what I was going through. So after months of anxiety and depression my dr suggested Zoloft. I was scared to take it. the thought of being on Zoloft scared me. I sat in my car holding the Zoloft and cried “I’m gonna be on medication my whole life”. But I took the Zoloft! I felt really panicky the first two weeks but after the two weeks, I noticed my anxiety calm down and panic attacks went away I was on it for about a year and and decided to wean myself off of it. I’m seriously so happy I decided to take Zoloft it helped me when I needed it I’ve been off of Zoloft since and I’m happy and healthy. My advice is take it if you have no other choice yes it’s scary but, don’t take advice from people who don’t suffer from anxiety and depression!! It helped me so much. Dom”

10 / 10
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Was scared to start September 3, 2020

For Depression: “About 6 weeks ago, I started Zoloft at 25 mg for GAD, mild depression, and some PTSD and OCD symptoms. Before you continue reading, please understand that my experience likely will not be yours, as is the case with every single review you'll read. Do not be scared to start. It absolutely helped. My overall mood didn't change much, but it helped the physical symptoms of my anxiety and helped me cope with my life stresses. I began to enjoy doing things I love again. I still had bad days, but I was overall functioning well and productive, although I still had not the best outlook on life. Side effects I experienced: insomnia, daily headaches similar to hangovers, shakiness, increased depression the first week, decreased appetite, menstrual changes, and decreased libido. Again, this is just my experience. Do not be afraid to give it a try, people are much more likely to leave negative reviews, I just wanted to leave a review to help others. Best of luck, you've got this!”

6 / 10
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Abby · Taken for less than 1 month August 23, 2020

For Panic Disorder: “Hi everyone! My name is Abby and I’m 24. I’ve always been a worrier, and have been in and out of therapy since college, and consistently for the past year now. While I am a huge fan of therapy, no matter how hard I worked I still struggled with intense anxiety and moderate depression. I went to the doctor once last November and was prescribed Zoloft, but didn’t take it because I was scared to start a medication. After another rough patch this summer, I went back and took Zoloft. It’s a game changer. I still am me - but a much more stable, level-headed version. I am more present and can sort out my anxious thoughts much more easily. For the first time in forever, I’m feeling happy and hopeful about the future. All I want to say is, if you’ve been struggling, please seek out professional medical help and do not be afraid to take the medication you are prescribed. It’s absolutely possible to feel like you again. All my love ♥️”

10 / 10
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Frequently asked questions

ozzy21 · Taken for 1 to 2 years December 23, 2020

For Depression: “A few a year ago I smoked a high strain of cannabis and a few days later started to have severe anxiety, something triggered and I went into a deep depression. I was living the life, amazing career and beautiful girlfriend, everything I could ask for. Then this hit and I was so deep into depression that I didn't want to continue anymore. Antidepressants were my last choice, and THANKFUL I did. I didn't want to get on them because I thought I was weak and couldn't get over it on my own. Symptoms were high depersonalization and feeling detached, hopelessness, isolation, etc. I thought it was over at age 24... but listen... It's not. I am living the best life now and have my dream job. Antidepressants do not make you weak. They make you brave and proud of yourself at the end of it. I have become a better person from all of this and you will too. Do not give up, because you will be back to normal. It took a good 6 - 8 months before they did their job. It takes awhile to kick in.”

10 / 10
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Thistooshallpassxo · Taken for 1 to 6 months September 5, 2017

For Depression: “MOTIVATION MONDAY: to the lovely folks just like me who spend hours searching online forums looking for something to give you hope. I understand. I want to share what I've learned. When I was in my darkest place I would read reviews about meds not working or awful side effects. I was convinced no medication would work for me because of this. BUT this one did! Please know, there is a light at the end of the tunnel! ALWAYS. You are not alone. You are not crazy. Don't give up. You'll be feeling normal again before you know it. This too shall pass!”

10 / 10
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wbb July 31, 2008

For Depression: “I remember reading people's opinions, online, of the drug before I took it and it scared me away from it. Then I finally decided to give it a try and it has been the best choice I have made. I have been on it for over 4 months and I feel great. I'm on 100mg and I don't have any side effects. When I first started I did notice that my hands would tremble but then it subsided. So honestly, don't listen to all the negativity because what doesn't work for some works amazing for others. So go based on youself and not everyone else. It may be a blessing in diguise. The pill is not meant to make you be all happy go lucky and see "butterflies and roses", its meant to help put the chemicals in your mind in balance so you can just be who you are and not overly depressed. I still get sad some times, but that is normal, that is life, and it's up to people to take control to make a change. I did so by getting on this pill.”

10 / 10
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Jay · Taken for 1 to 6 months June 8, 2020

For Depression: “I started taking zoloft after 8 months of post concussion syndrome symptoms. My anxiety and very low mood were affecting every aspect of my life. I was suicidal. I started with 50mg for the first month. Only side effects for me was a bit of nausea the first week and a lack of appetite. By week 4 we went up to 100mg and everything has improved significantly! I can separate emotions from facts which I couldn't do before. The people I thought were "against me" don't seem to bother me whatsoever now. I've gotten my life back. I have energy and an optimistic attitude. My friends and family have noticed in big ways. It's been a life changed for me. The only thing I would say are side effects Low libido Shortened Sleep. I usually wake up in the middle of the night now.”

10 / 10
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Sunshine October 26, 2020

For Panic Disorder: “I’ve been having panic attacks/ anxiety since I can remember. (I’m 27). About 3 years ago I couldn’t take it anymore I quit drinking, quit drinking caffeine, stopped smoking cigarettes. Nothing helped. In January of 2020 after trying about 7 different medications, (at this point I was terrified after so many failed attempts) I didn’t want to try anything else, nothing seemed to help. So let me Start by saying ZOLOFT SAVED MY LIFE, let me say it again so the people in the back can hear, ZOLOFT SAVED MY LIFE. I feel like everything is so much brighter, I gained some weight but that is minor to not have panic attacks for days on end. I’m on 50mg I started very slow which helped the side effects I started at 12.5mg and after 3 days bumped up to 25mg and after a week to 50mg. I couldn’t be happier and feel like for the first time I have my life ahead of me. I would recommend this drug to anyone. It changed my life for the better.”

10 / 10
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Grateful October 2, 2019

For Depression: “Hi guys - just like all of you I scrolled these reviews for hours both before and during my Zoloft treatment. I’ve been on Zoloft 5 weeks now (7 weeks if you include the first two weeks on 25mg which is below therapeutic dose). I tried two SSRI’s before Zoloft and each made me violently ill or suicidal. The side effects of Zoloft have been minimal none - just a mild headache as I up my dosage. I have currently moved up to 100mg, week 6!! My experience has been incredibly positive. I let go of things easier such as fights with partner and I don’t have horrible recurring thoughts. I still have had a total of about 8 bad days over the course of Zoloft but that is life!! This is not a magic pill. In fact - my anxiety has subsided so much that I’ve become incredibly bored! What do I do with all this free time?! It’s made me reach my life’s purpose and it has given me hope. Please don’t give up. I wish I tried Zoloft sooner. Sending love and hope to you all x”

8 / 10
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xxmorgixx August 6, 2021

For Obsessive Compulsive Disorder: “I read these reviews over and over again to calm myself with what I was going through. Although thinking back it might of been obsessive. I have been taking this since December of 2020 when I had a bad mental break down where I was crying for a month straight couldn’t work and was having panic attacks all day everyday! This medication has saved my life! I could not stop thinking these obsessive thoughts everyday all day. That absolutely drove me up the wall crazy. It took about a month or two to finally start getting back to myself again. I am able to work again and able to take care of my family! I have happy moments now. Instead of always being in an obsessive thought and trying to get rid of it I can now accept the thought as a thought or yeah maybe that could happen and go about my day. Please don’t give up on this medication. The side effects do subside and you’ll feel like yourself again I promise!”

10 / 10
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Anonymous August 5, 2008

For Depression: “I've been on Zoloft 50mg for over two years. I am a more relaxed and easy-going person because of Zoloft. Prior to starting the medicine, I was anxious all the time, worried constantly about everything, and suffered periods of depression and hopelessness. Now I am a better wife, friend, and person in general.”

9 / 10
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NP93 · Taken for 1 to 6 months January 12, 2017

For Social Anxiety Disorder: “Half the reviews on here are a load of garbage. They range from "the side effects are too awful" to "It gives me more anxiety". Do yourself a favor and do not read to any review from anyone who has taken this drug for less than 8 weeks. If you are serious about reducing your anxiety, then grow some balls and give zoloft time to work. Yes, you're going to have a number of side effects in the beginning, ranging from drowsiness, nausea, sexual disfunction, loss of appetite, and even increased anxiety. Guess what, nearly all of these are going to disappear after the first two weeks. In fact, all of the side effects disappeared for me, and it wasn't until around week 8 that I felt the glorious power of this drug. GIVE IT TIME”

10 / 10
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Carson47 · Taken for 5 to 10 years June 12, 2021

For Panic Disorder: “I started having panic attacks/ anxiety since I was 16 years old. Things got real bad in my late 30’s early 40’s. I would drink alcohol at night to self medicate. I tried therapy and my doctor would always try to put me on an a anti depressant. I was too scared ,thinking it would make it worse! After having a nervous breakdown and being hospitalized 6 years ago they put me on Zoloft 50gm and Lamictal 25gm and I finally have my life back!!! It was like a light switch finally came on in my head! So much more calm, not worrying all the time, not wanting alcohol to cope. I haven’t had a drink in 6 years! It has truly has been a life saver for me and I give God all the glory. Sides effects were minimal, 1st week - insomnia and night sweats after that, completely fine! I wish all of you the best of luck and it will get better! Trust me, I thought I was hopeless!”

10 / 10
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More FAQ

Snakeye · Taken for less than 1 month September 24, 2020

For Major Depressive Disorder: “Greetings! I have been on 13 antidepressants in the last ten years for my MDD and GAD. Some worked better than others, but most pooped out after a relatively short time. Others gave me dreadful side-effects like akathisia. I am seeing my third psychiatrist and he has suggested Zoloft. I have very little hope of it working. I begin my regiment on Friday so that I have the weekend as a slight buffer before work on Monday. Positive thoughts and prayers are appreciated. I will follow up this "review" in a few months whether successful or not. I am a married father of four and I just want to be a better husband to my wife and a better father to my children. Most of my friends and colleagues would be surprised if they knew the depth of my mental illness. I hope that all that are reading this find peace and healing.”

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Dani F. September 6, 2016

For Depression: “I told myself that if a miracle happened and this worked, that I would write a review. Let me start off by saying that this drug, literally, saved my LIFE. I've always battled anxiety and panic attacks, and was on a small dose of Paxil and that seemed to take the edge off. I took it on and off for years. After I had my second baby at 28, I got terrible postpartum depression. I had thoughts of suicide, racing thought constantly, couldn't nap and took forever to fall asleep at night. I literally spent three months just thinking and obsessing over how horrible I felt. I wanted to crawl out of my skin and die. I was barely showering, brushing my teeth and hair and would stay in the same sweatpants and shirt for days. I could go on forever by I'll get to the point. After three months of pure hell, I went to my doctor for help. I was prescribed 50 ML of Zoloft. After being on it for 4 weeks, I stopped taking it because it wasn't working. After going another 2 weeks feeling miserable, I went to my doctor again. She recommended we up the dose and stay on it for atleast 6 weeks. Well, after two weeks on 100 ML, I realized I was feeling better. I would go minutes without thinking negatively, then I would go hours, then full days. It feels SO good to feel like myself again. I truly thought I would be miserable forever. Please get help and try something if you are feeling terrible. Everyone is curable with the right drug and right dose. I wish I got help sooner. TRY THIS! It will work! If for some reason it doesn't, try something else! GET HELP NOW! I was doing the same thing you are - googling all types of antidepressants convinced there was no cure and they would never work. Stop spending your life wondering when you will be yourself again. You WILL get better and be 100% your old self again with an antidepressant!”

10 / 10
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Mich · Taken for 1 to 6 months February 10, 2020

For Depression: “This drug saved my life. I started having chronic anxiety and depression very suddenly, and insomnia. I am so thankful for the positive and encouraging reviews on websites like this, because they helped me push through this difficult time, and I hope to do the same for someone else. I agree with many other reviews that it does get worse before it gets better. My anxiety increased at first, I think out of desperation for each day to finally be the day I would feel normal again. But it takes time and patience, and there will be ups and downs. I started seeing improvement around 4 weeks, but took a dive again around week 5 before increasing my dosage. Now I am at about week 7-8 and I would say 90% myself again. I highly recommend doing therapy too, and Xanax has helped curb the increased anxiety while my body adapts. Side effects are minimal, just nausea if I don’t take it with food. Zoloft helped me get my mind back under control and enjoy life again!”

10 / 10
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Stone · Taken for 1 to 6 months June 7, 2020

For Depression: “I’m 50 and have struggled with anxiety because of my 26 year relationship with my wife. After 60 days I don’t have the breakdowns any more and can function. Zoloft helped me to close off to her and begin to feel safe emotionally. It really works.”

9 / 10
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Butterfly · Taken for less than 1 month June 5, 2020

For Social Anxiety Disorder: “I have GAD, I knew I was needing support emotionally. 15 years ago I had used Zoloft and it worked well, so I asked my doctor if I could use it again. So I started on 25mg and after 2 weeks I upped to the 50 mg my doc prescribed. Honestly week 3 and 4 were the worst for me because I couldn't eat and I felt so much worse with anxiety and lack of peace of mind. Because I was working from home, and others mentioned that the first month was bad. I felt like I was being pushed under emotionally. I had to do a lot of self talk like "I am not my feelings, this will pass" etc. I took my Zoloft at night and it seemed by evening I always felt better, but mornings were so difficult. But right at end of week four, a cloud lifted and I felt peaceful and calm. So I appreciate others sharing their experience because that's exactly what happened to me. And I pushed through it and I'm glad I did because I feel much better. Hope that helps someone in week 3. It does get better. Hang in there.”

9 / 10
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Anonymous · Taken for 1 to 6 months September 3, 2020

For Panic Disorder: “Hi everyone. Around a month and a half ago I had hit a VERY LOW point in my life after a panic attack. I knew there was something wrong. I couldn’t sleep, I was CONSTANTLY worrying, and I felt very empty. I had bad tremors, I felt numb, and could not stop crying. I developed general anxiety disorder. It put me in a deep spiral. After being prescribed klonopin to help me sleep, I knew I had to try out a medication. My doctor put me in Zoloft 25mg, and a week later bumped me to 50mg. Zoloft literally saved my life. I never thought I could begin to feel myself again, no worrying, not anxious to do things, and very much more present. I will say it gets much worse before it gets better. Stick it out. Literally changed my life.”

10 / 10
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Sb · Taken for 6 months to 1 year August 25, 2020

For Social Anxiety Disorder: “So far so good :) I used to have anxiety attacks over little things like answering the phone or job interviews and definitely missed out on a lot of my college experience because my social anxiety was so bad. I’ve been on Zoloft for about 8 months now for GAD as well as social anxiety and I can say I feel almost like a new person. I now don’t fear going places like the bank or gas station alone. The thought of having to call someone I don’t know on the phone is easy breezy and I now have a job which involves me talking to customers all day, it’s truly amazing!!!! Give it time to work, but remember everyone’s different so don’t be discouraged :)”

8 / 10
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Xavi August 21, 2019

For Panic Disorder: “This drug Zoloft saved my life. I was in the darkest depths. Rampant anxiety to the point it was almost impossible to go to work. I couldn't go out in public, get haircuts or go to the dentist because I would have panic attacks. Every time I woke up I was sad that I was alive because the anxiety would hit me like a flood of terror. Zoloft took me 180. I am absolutely fine now. I still have minor anxiety but just a normal human amount. I am happy and healthy and I have a girlfriend for the first time in my life and I am working out and I am doing well at work. The bad side effects are non existent for me. Sleep, appetite and weight were unaffected. When I started Zoloft the anxiety skyrocketed. But after 4 weeks I woke up one morning and it was like an angel drew the curtains open for me and the light was shining. I woke up and instantly felt better and had hope for the future. If it weren't for Zoloft, I wouldn't have made it. ”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.