Skip to Content

Zoloft (sertraline) Drug Interactions

A total of 617 drugs are known to interact with Zoloft (sertraline).

  • 140 major drug interactions
  • 470 moderate drug interactions
  • 7 minor drug interactions

Show all medications in the database that may interact with Zoloft (sertraline).

Check for interactions

Type in a drug name to check for interactions with Zoloft (sertraline).

Most frequently checked interactions

View interaction reports for Zoloft (sertraline) and the medicines listed below.

Zoloft (sertraline) alcohol/food interactions

There is 1 alcohol/food interaction with Zoloft (sertraline)

Zoloft (sertraline) disease interactions

There are 10 disease interactions with Zoloft (sertraline) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.