Zoloft Drug Interactions
Currently displaying a list of 673 drugs known to interact with Zoloft (sertraline).
- 157 major drug interactions
- 511 moderate drug interactions
- 5 minor drug interactions
Medications known to interact with Zoloft
Note: Showing generic names only.
5
A
- abametapir topical
- abarelix
- abciximab
- abiraterone
- abrocitinib
- acalabrutinib
- acetazolamide
- acetohexamide
- acetylcarbromal
- acrivastine
- adagrasib
- adenosine
- ado-trastuzumab emtansine
- albuterol
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alpelisib
- alprazolam
- alteplase
- amifampridine
- amiloride
- amiodarone
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- anagrelide
- anisindione
- anistreplase
- antithrombin (recombinant)
- antithrombin iii
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- ardeparin
- arformoterol
- argatroban
- aripiprazole
- arsenic trioxide
- asciminib
- asenapine
- aspirin
- astemizole
- atomoxetine
- avapritinib
- azatadine
- azithromycin
B
- baclofen
- bedaquiline
- belzutifan
- bendroflumethiazide
- benzgalantamine
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- betrixaban
- bicalutamide
- biperiden
- bisacodyl
- bismuth subsalicylate
- bitolterol
- bivalirudin
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromfenac
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabozantinib
- cangrelor
- cannabidiol
- cannabis
- caplacizumab
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- casanthranol
- cascara sagrada
- castor oil
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- chlophedianol
- chloral hydrate
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- choline salicylate
- cilostazol
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clemastine
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clopidogrel
- clorazepate
- clozapine
- cobicistat
- codeine
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- dabigatran
- dabrafenib
- dalteparin
- danaparoid
- dantrolene
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deferasirox
- defibrotide
- degarelix
- desipramine
- desirudin
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- dichlorphenamide
- diclofenac
- dicumarol
- diethylpropion
- difelikefalin
- diflunisal
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- dipyridamole
- disopyramide
- disulfiram
- divalproex sodium
- dofetilide
- dolasetron
- donepezil
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drotrecogin alfa
- duloxetine
- duvelisib
E
- edoxaban
- efavirenz
- eletriptan
- eliglustat
- encorafenib
- enoxaparin
- entacapone
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- epoprostenol
- eptifibatide
- ergotamine
- eribulin
- erythromycin
- escitalopram
- eslicarbazepine
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethosuximide
- ethotoin
- etodolac
- etrasimod
- evening primrose
- ezogabine
F
- famotidine
- felbamate
- fenfluramine
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- fingolimod
- flavoxate
- flecainide
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- flutamide
- fluvoxamine
- fondaparinux
- formoterol
- fosamprenavir
- foscarnet
- fosphenytoin
- fostamatinib
- fostemsavir
- frovatriptan
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gatifloxacin
- gemifloxacin
- gepirone
- gilteritinib
- ginkgo
- givinostat
- glasdegib
- glimepiride
- glipizide
- glyburide
- glycerin
- glycerol phenylbutyrate
- goserelin
- granisetron
- grepafloxacin
H
- halazepam
- halofantrine
- haloperidol
- halothane
- heparin
- heroin
- histrelin
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyzine
I
- ibritumomab
- ibrutinib
- ibuprofen
- ibutilide
- idarubicin
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- indacaterol
- indapamide
- indomethacin
- inotersen
- inotuzumab ozogamicin
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iobenguane I 123
- iodine i 131 tositumomab
- ioflupane I 123
- iohexol
- iomeprol
- iopamidol
- isocarboxazid
- isoetharine
- isoniazid
- isoproterenol
- itraconazole
- ivabradine
- ivosidenib
K
L
- labetalol
- lacosamide
- lactitol
- lactulose
- lamotrigine
- lapatinib
- larotrectinib
- lasmiditan
- lefamulin
- lemborexant
- lenvatinib
- lepirudin
- leuprolide
- levalbuterol
- levetiracetam
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- lindane topical
- linezolid
- liothyronine
- liotrix
- lisdexamfetamine
- lithium
- lofexidine
- lomefloxacin
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- macimorelin
- magnesium citrate
- magnesium hydroxide
- magnesium salicylate
- mannitol
- maprotiline
- mavacamten
- mavorixafor
- mazindol
- meclofenamate
- mefenamic acid
- mefloquine
- melatonin
- meloxicam
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaxalone
- methadone
- methamphetamine
- methazolamide
- methocarbamol
- methohexital
- methotrimeprazine
- methsuximide
- methyclothiazide
- methylene blue
- methylphenidate
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metronidazole
- metyrosine
- mexiletine
- midazolam
- midostaurin
- mifepristone
- milnacipran
- mineral oil
- mirtazapine
- mitotane
- mobocertinib
- molindone
- morphine
- morphine liposomal
- moxifloxacin
N
- nabilone
- nabumetone
- nalbuphine
- naproxen
- naratriptan
- nateglinide
- nebivolol
- nefazodone
- nelfinavir
- nilotinib
- nilutamide
- nitisinone
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- orphenadrine
- osilodrostat
- osimertinib
- oxaliplatin
- oxaprozin
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
P
- pacritinib
- paliperidone
- palonosetron
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pasireotide
- pazopanib
- pentamidine
- pentazocine
- pentobarbital
- perampanel
- perflutren
- pergolide
- perphenazine
- phenacemide
- phendimetrazine
- phenelzine
- phenobarbital
- phenolphthalein
- phensuximide
- phentermine
- phenylbutazone
- phenylpropanolamine
- phenytoin
- pimavanserin
- pimozide
- pirbuterol
- pirfenidone
- piroxicam
- pirtobrutinib
- pitolisant
- plasminogen, human
- plicamycin
- polyethylene glycol 3350
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- ponesimod
- porfimer
- posaconazole
- pralsetinib
- pramipexole
- prasugrel
- pregabalin
- primaquine
- primidone
- probucol
- procainamide
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propiomazine
- propofol
- propoxyphene
- propranolol
- protein c
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramucirumab
- ranolazine
- rasagiline
- regorafenib
- relugolix
- remifentanil
- remimazolam
- repaglinide
- reteplase
- revumenib
- ribociclib
- rifampin
- rifapentine
- rilpivirine
- risperidone
- ritodrine
- ritonavir
- rivaroxaban
- rivastigmine
- rizatriptan
- romidepsin
- ropinirole
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
S
- safinamide
- salmeterol
- salsalate
- saquinavir
- scopolamine
- secobarbital
- selegiline
- selpercatinib
- senna
- sevoflurane
- sibutramine
- siponimod
- sirolimus
- sodium oxybate
- sodium salicylate
- sodium thiosalicylate
- sofpironium topical
- solifenacin
- sorafenib
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- streptokinase
- sufentanil
- sulfamethoxazole
- sulfinpyrazone
- sulindac
- sumatriptan
- sunitinib
- suvorexant
T
- tacrine
- tacrolimus
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- tazemetostat
- tebentafusp
- tedizolid
- telavancin
- telithromycin
- telotristat
- temazepam
- temsirolimus
- tenecteplase
- terbinafine
- terbutaline
- terfenadine
- tetrabenazine
- thalidomide
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- timolol ophthalmic
- tinzaparin
- tirofiban
- tizanidine
- tolazamide
- tolbutamide
- tolcapone
- tolmetin
- tolterodine
- topiramate
- toremifene
- torsemide
- tositumomab
- tovorafenib
- tramadol
- tranylcypromine
- trazodone
- treprostinil
- triamterene
- triazolam
- trichlormethiazide
- triclabendazole
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trofinetide
- troglitazone
- troleandomycin
- tryptophan
- turmeric
U
V
- valbenazine
- valerian
- valproic acid
- vandetanib
- vardenafil
- vasopressin
- vemurafenib
- venlafaxine
- vigabatrin
- vilazodone
- voclosporin
- vorapaxar
- voriconazole
- vortioxetine
W
Z
Zoloft alcohol/food interactions
There is 1 alcohol/food interaction with Zoloft (sertraline).
Zoloft disease interactions
There are 10 disease interactions with Zoloft (sertraline) which include:
- depression
- hyponatremia
- glaucoma
- liver disease
- mania
- platelet function
- seizure disorders
- SIADH
- renal dysfunction
- weight loss
Report options
QR code containing a link to this page
More about Zoloft (sertraline)
- Zoloft consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1,972)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Generic availability
- Support group
- Drug class: selective serotonin reuptake inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Vraylar
Vraylar is a once a day antipsychotic medication used to treat mental health or mood disorders ...
Reviews & ratings
Lexapro
Lexapro is used to treat anxiety and major depressive disorder. Learn about side effects ...
Reviews & ratings
Featured
Rexulti
Rexulti (brexpiprazole) is a prescription antipsychotic medication used in the treatment of major ...
Reviews & ratings
Seroquel
Seroquel is used to treat the symptoms of schizophrenia, bipolar disorder and major depressive ...
Reviews & ratings
Xanax
Xanax (alprazolam) is a benzodiazepine medication used to treat anxiety and panic disorders ...
Reviews & ratings
Citalopram
Citalopram is an antidepressant (selective serotonin reuptake inhibitor) and is used to treat ...
Reviews & ratings
Lorazepam
Lorazepam is in a group of drugs called benzodiazepines and is used to treat anxiety disorders ...
Reviews & ratings
Venlafaxine
Venlafaxine is used to treat major depressive disorder, anxiety, and panic disorder. Learn about ...
Reviews & ratings
Buspirone
Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability and dizziness ...
Reviews & ratings
Alprazolam
Alprazolam is used to treat anxiety disorders, panic disorders, and anxiety. Learn about side ...
Reviews & ratings
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
