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Medications for Major Depressive Disorder

Other names: Clinical Depression; Major Depression; MDD; Unipolar Depression; Unipolar Disorder

About Major Depressive Disorder

Major depressive disorder is characterized by depressed mood and loss of interest in normal activities and relationships, interfering with a person's ability to carry out normal activities.

Drugs used to treat Major Depressive Disorder

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Zoloft 6.7 109 reviews
Rx C N X

Generic name: sertraline systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Wellbutrin XL 7.0 99 reviews
Rx C N X

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Trintellix 6.0 382 reviews
Rx C N X

Generic name: vortioxetine systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

bupropion 7.0 322 reviews
Rx C N X

Generic name: bupropion systemic

Brand names:  Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion SR, Forfivo XL …show all

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Prozac 6.3 81 reviews
Rx C N X

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Lexapro 6.2 82 reviews
Rx C N X

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Cymbalta 5.9 92 reviews
Rx C N X

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Abilify 6.0 106 reviews
Rx C N X

Generic name: aripiprazole systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Rexulti 6.4 186 reviews
Rx N X

Generic name: brexpiprazole systemic

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

aripiprazole 6.0 119 reviews
Rx C N X

Generic name: aripiprazole systemic

Brand name:  Abilify

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Effexor XR 6.7 91 reviews
Rx C N X

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

sertraline 6.8 163 reviews
Rx C N X

Generic name: sertraline systemic

Brand name:  Zoloft

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Pristiq 5.9 109 reviews
Rx C N X

Generic name: desvenlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

trazodone 6.7 29 reviews
Rx C N X

Generic name: trazodone systemic

Brand names:  Desyrel, Desyrel Dividose

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

vortioxetine 6.1 458 reviews
Rx C N X

Generic name: vortioxetine systemic

Brand name:  Trintellix

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Viibryd 5.5 183 reviews
Rx C N X

Generic name: vilazodone systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

brexpiprazole 6.3 195 reviews
Rx N X

Generic name: brexpiprazole systemic

Brand name:  Rexulti

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Effexor 5.8 52 reviews
Rx C N X

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Remeron 7.7 49 reviews
Rx C N X

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Wellbutrin SR 8.1 24 reviews
Rx C N X

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

venlafaxine 6.4 200 reviews
Rx C N X

Generic name: venlafaxine systemic

Brand names:  Effexor XR, Effexor

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

fluoxetine 6.7 112 reviews
Rx C N X

Generic name: fluoxetine systemic

Brand name:  Prozac

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

mirtazapine 7.0 148 reviews
Rx C N X

Generic name: mirtazapine systemic

Brand names:  Remeron, Remeron SolTab

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

duloxetine 5.9 110 reviews
Rx C N X

Generic name: duloxetine systemic

Brand names:  Cymbalta, Irenka

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

escitalopram 6.3 123 reviews
Rx C N X

Generic name: escitalopram systemic

Brand name:  Lexapro

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Learn more about Major Depressive Disorder

IBM Watson Micromedex

Symptoms and treatments

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.