Zoloft Alternatives Compared
| Zoloft (sertraline) | Rexulti (brexpiprazole) | Bupropion |
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| Zoloft (sertraline) | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Zoloft (sertraline) | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Zoloft has an average rating of 7.3 out of 10 from a total of 1979 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 499 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2913 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Zoloft side effects |
View all Rexulti side effects |
View all Bupropion side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Zoloft prices |
View all Rexulti prices |
View all Bupropion prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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66 hours |
91 hours |
30 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 674 drugs are known to interact with Zoloft:
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A total of 601 drugs are known to interact with Rexulti:
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A total of 560 drugs are known to interact with Bupropion:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 30, 1991 |
July 10, 2015 |
December 30, 1985 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.