Zoloft Alternatives Compared
| Zoloft | Rexulti | Bupropion |
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| Zoloft (sertraline) | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Major Depressive Disorder, Panic Disorder, Obsessive Compulsive Disorder... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression. Most people experience some improvement in their symptoms within 1 to 2 weeks of starting... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Zoloft (sertraline) | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Zoloft has an average rating of 7.2 out of 10 from a total of 1722 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
Rexulti has an average rating of 6.4 out of 10 from a total of 379 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2620 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include:
See also: Zoloft side effects in more detail. |
See also: Rexulti side effects in more detail. |
Commonly reported side effects include:
See also: bupropion side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Zoloft prices and generic prices |
View all Rexulti prices |
View all bupropion prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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66 hours |
91 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 642 drugs are known to interact with Zoloft:
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A total of 534 drugs are known to interact with Rexulti:
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A total of 484 drugs are known to interact with bupropion:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 30, 1991 |
July 10, 2015 |
December 30, 1985 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.