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Zoloft Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zoloft Remove Zoloft from your drug comparison Cymbalta Remove Cymbalta from your drug comparison Bupropion Remove Bupropion from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Zoloft sertraline Remove Zoloft from your drug comparison Cymbalta duloxetine Remove Cymbalta from your drug comparison Bupropion Remove Bupropion from your drug comparison

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Obsessive Compulsive Disorder, Major Depressive Disorder, Panic Disorder... View more

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 1548 reviews

View all 1544 reviews

View all 2322 reviews

Drug Class

Side Effects

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, xerostomia.

See the full Zoloft side effects document.

Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, xerostomia.

See the full Cymbalta side effects document.

Commonly reported side effects include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, xerostomia.

See the full bupropion side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 30 tablet
Dosage 100 mg
Per Unit* $13.13
Cost* $393.84

View all Zoloft prices and generic prices

Quantity 21 delayed release capsule
Dosage 60 mg
Per Unit* $11.61
Cost* $243.73

View all Cymbalta prices and generic prices

Quantity 30 each
Dosage 150 mg/24 hours
Per Unit* $1.64
Cost* $49.22

View all bupropion prices

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Generic Availability

Yes

Yes

Yes (this medicine)

Dosage Form(s) Available
  • Oral concentrate
  • Oral tablet
  • Oral delayed release capsule
  • Oral tablet
  • Oral tablet, extended release

Brand Names

N/A

 Other duloxetine brands include: Drizalma Sprinkle, Irenka Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

66 hours

17 hours

30 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 619 drugs are known to interact with Zoloft:

  • 141 major drug interactions (560 brand and generic names)
  • 471 moderate drug interactions (1937 brand and generic names)
  • 7 minor drug interactions (35 brand and generic names)

A total of 563 drugs are known to interact with Cymbalta:

  • 101 major drug interactions (449 brand and generic names)
  • 439 moderate drug interactions (1911 brand and generic names)
  • 23 minor drug interactions (187 brand and generic names)

A total of 422 drugs are known to interact with bupropion:

  • 212 major drug interactions (922 brand and generic names)
  • 205 moderate drug interactions (859 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

December 30, 1991

N/A

December 30, 1985

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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