Comparing Alprazolam vs Zoloft
| Alprazolam | Zoloft (sertraline) |
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| Alprazolam | Zoloft (sertraline) |
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Prescription only
Alprazolam effectively relieves anxiety; however, it is addictive, and withdrawal symptoms can be severe. Other common side effects include low blood pressure, dizziness on standing (which may... View more |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
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| More about Alprazolam | More about Zoloft (sertraline) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Alprazolam has an average rating of 8.6 out of 10 from a total of 1494 ratings on Drugs.com. 83% of reviewers reported a positive effect, while 8% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1975 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Alprazolam side effects |
View all Zoloft side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Alprazolam prices |
View all Zoloft prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Alprazolam Intensol, Xanax, Xanax XR |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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20 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 563 drugs are known to interact with Alprazolam:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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October 16, 1981 |
December 30, 1991 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
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Ozempic
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Cymbalta
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Paroxetine
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Diazepam
Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Learn ...
Lorazepam
Lorazepam is in a group of drugs called benzodiazepines and is used to treat anxiety disorders ...
Venlafaxine
Venlafaxine is used to treat major depressive disorder, anxiety, and panic disorder. Learn about ...
Buspirone
Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability and dizziness ...
Duloxetine
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.