Skip to Content
Print Share

Medications for Premenstrual Dysphoric Disorder

Other names: PMDD

About Premenstrual Dysphoric Disorder:  Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, and tension before menstruation. The symptoms are far more severe than those seen with premenstrual syndrome and often disrupt work and relationships.

Drugs Used to Treat Premenstrual Dysphoric Disorder

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Prozac C N X 14 reviews
7.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

fluoxetine C N X 93 reviews
8.0

Generic name: fluoxetine systemic

Brand names:  Prozac, Sarafem, Rapiflux, Selfemra …show all

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Zoloft C N X 36 reviews
8.0

Generic name: sertraline systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Beyaz X N X 12 reviews
7.0

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Yaz X N X 74 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

sertraline C N X 44 reviews
8.0

Generic name: sertraline systemic

Brand name:  Zoloft

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Sarafem C N X 21 reviews
8.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

citalopram Off Label C N X 18 reviews
9.0

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Paxil CR D N X 2 reviews
9.0

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

escitalopram Off Label C N X 14 reviews
9.0

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Yasmin X N X 9 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

bupropion Off Label C N X 4 reviews
7.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

paroxetine D N X 7 reviews
9.0

Generic name: paroxetine systemic

Brand name:  Paxil CR

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

drospirenone / ethinyl estradiol X N X 131 reviews
6.0

Generic name: drospirenone / ethinyl estradiol systemic

Brand names:  Yaz, Yasmin, Gianvi, Ocella, Loryna, Syeda, Vestura, Nikki, Zarah, Jasmiel, Lo-Zumandimine, Zumandimine …show all

Drug class: contraceptives

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Gianvi X N X 22 reviews
6.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

venlafaxine Off Label C N X 3 reviews
9.0

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Pamprin Multi-Symptom Menstrual Relief N N X 1 review Rate

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

drospirenone / ethinyl estradiol / levomefolate calcium X N X 13 reviews
7.0

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Brand names:  Beyaz, Rajani

Drug class: contraceptives

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, Prescribing Information

Ocella X N X 1 review
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Midol PMS Maximum Strength N N X Add review Rate

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

Rapiflux C N X Add review Rate

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

acetaminophen / pamabrom / pyrilamine N N X 1 review Rate

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Brand names:  Pamprin Multi-Symptom Menstrual Relief, Midol PMS Maximum Strength, Pamprin Maximum Pain, Premsyn PMS, Menstrual Pain Relief, Menstrual PMS …show all

Drug class: analgesic combinations

For consumers: interactions,

Selfemra C N X Add review Rate

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Loryna X N X 5 reviews
2.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pamabrom N N Add review
10

Generic name: pamabrom systemic

Brand names:  Diurex Water Capsules, Aqua-Ban, Diurex Aquagels

Drug class: miscellaneous diuretics

For consumers: interactions,

Alternative treatments for Premenstrual Dysphoric Disorder

The following products are considered to be alternative treatments or natural remedies for Premenstrual Dysphoric Disorder. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Premenstrual Dysphoric Disorder.

Learn more about Premenstrual Dysphoric Disorder

Drugs.com Health Center

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Treatment Options

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drugs.com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Explore Apps
Hide