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Medications for Premenstrual Dysphoric Disorder

Other names: PMDD

What is Premenstrual Dysphoric Disorder:  Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, and tension before menstruation. The symptoms are far more severe than those seen with premenstrual syndrome and often disrupt work and relationships.

Medications to treat Premenstrual Dysphoric Disorder

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Prozac Rx C N X 11 reviews
8.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Zoloft Rx C N X 31 reviews
8.0

Generic name: sertraline systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
fluoxetine Rx C N X 76 reviews
8.0

Generic name: fluoxetine systemic

Brand names:  Prozac, Sarafem, Rapiflux, Selfemra …

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Beyaz Rx X N X 10 reviews
8.0

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Yaz Rx X N X 58 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Sarafem Rx C N X 19 reviews
8.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
sertraline Rx C N X 37 reviews
8.0

Generic name: sertraline systemic

Brand name:  Zoloft

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Midol Maximum Strength Menstrual OTC N N X Add review
9.0

Generic name: acetaminophen / caffeine / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions,

 
Paxil CR Rx D N X 1 review
9.0

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Yasmin Rx X N X 6 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
citalopram Off Label Rx C N X 13 reviews
9.0

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
escitalopram Off Label Rx C N X 10 reviews
9.0

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Gianvi Rx X N X 17 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
paroxetine Rx D N X 3 reviews
9.0

Generic name: paroxetine systemic

Brand name:  Paxil CR

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
bupropion Off Label Rx C N X 3 reviews
7.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Pamprin Multi-Symptom Menstrual Relief OTC N N X 1 review Add

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

 
venlafaxine Off Label Rx C N X 3 reviews
9.0

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Midol PMS OTC N N X Add review Add

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

 
Ocella Rx X N X 1 review
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Rapiflux Rx C N X Add review Add

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

 
drospirenone / ethinyl estradiol / levomefolate calcium Rx X N X 11 reviews
8.0

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Brand names:  Beyaz, Rajani

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
drospirenone / ethinyl estradiol Rx X N X 87 reviews
7.0

Generic name: drospirenone / ethinyl estradiol systemic

Brand names:  Yaz, Yasmin, Gianvi, Ocella, Loryna, Syeda, Vestura …

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
Loryna Rx X N X 2 reviews
1.0

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Selfemra Rx C N X Add review Add

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
acetaminophen / pamabrom / pyrilamine OTC N N X 1 review Add

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Brand names:  Pamprin Multi-Symptom Menstrual Relief, Midol PMS, Midol PMS Maximum Strength, Premsyn PMS, Menstrual PMS …

Drug class: analgesic combinations

For consumers: interactions, side effects

 
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Alternative treatments for Premenstrual Dysphoric Disorder

The following products are considered to be alternative treatments or natural remedies for Premenstrual Dysphoric Disorder. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Premenstrual Dysphoric Disorder.

Learn more about Premenstrual Dysphoric Disorder

Drugs.com Health Center

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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