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Medications for Premenstrual Dysphoric Disorder

Other names: PMDD

Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, and tension before menstruation. The symptoms are far more severe than those seen with premenstrual syndrome and often disrupt work and relationships.

Drugs used to treat Premenstrual Dysphoric Disorder

The following list of medications are in some way related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
fluoxetine 8.6 117 reviews
Rx C N X

Generic name: fluoxetine systemic

Brand name:  Prozac

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Prozac 7.7 21 reviews
Rx C N X

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Zoloft 7.7 50 reviews
Rx C N X

Generic name: sertraline systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

sertraline 8.1 71 reviews
Rx C N X

Generic name: sertraline systemic

Brand name:  Zoloft

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Yaz 7.2 122 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

escitalopram Off-label 9.3 24 reviews
Rx C N X

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off-label: Yes

Beyaz 8.1 14 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

citalopram Off-label 8.9 27 reviews
Rx C N X

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off-label: Yes

bupropion Off-label 8.7 4 reviews
Rx C N X

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off-label: Yes

venlafaxine Off-label 9.5 4 reviews
Rx C N X

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off-label: Yes

paroxetine 8.1 11 reviews
Rx D N X

Generic name: paroxetine systemic

Brand name:  Paxil CR

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Yasmin 5.7 20 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Paxil CR 9.0 3 reviews
Rx D N X

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

drospirenone / ethinyl estradiol 6.4 233 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Brand names:  Yaz, Yasmin, Gianvi, Loryna, Nikki, Ocella, Syeda, Zarah, Zumandimine, Jasmiel, Lo-Zumandimine …show all

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Gianvi 6.8 29 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Pamprin Multi-Symptom Menstrual Relief 0.0 1 review
OTC N N X

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

Midol PMS Maximum Strength Rate Add review
OTC N N X

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

drospirenone / ethinyl estradiol / levomefolate calcium 7.9 15 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol / levomefolate calcium systemic

Brand name:  Beyaz

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Loryna 3.4 12 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Nikki 5.2 31 reviews
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Ocella 7.0 1 review
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pamabrom 2.0 1 review
OTC N N

Generic name: pamabrom systemic

Brand names:  Diurex Water Capsules, Aqua-Ban, Diurex Aquagels

Drug class: miscellaneous diuretics

For consumers: interactions, side effects

Syeda Rate Add review
Rx X N X

Generic name: drospirenone / ethinyl estradiol systemic

Drug class: contraceptives

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

acetaminophen / pamabrom / pyrilamine 0.0 1 review
OTC N N X

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Brand names:  Pamprin Multi-Symptom Menstrual Relief, Midol PMS Maximum Strength, Pamprin Maximum Pain, Premsyn PMS, Menstrual Pain Relief, Menstrual PMS …show all

Drug class: analgesic combinations

For consumers: interactions, side effects

Pamprin Maximum Pain Rate Add review
OTC N N X

Generic name: acetaminophen / pamabrom / pyrilamine systemic

Drug class: analgesic combinations

For consumers: interactions, side effects

Alternative treatments for Premenstrual Dysphoric Disorder

The following products are considered to be alternative treatments or natural remedies for Premenstrual Dysphoric Disorder. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Premenstrual Dysphoric Disorder.

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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