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Medications for Premenstrual Dysphoric Disorder

Other names: PMDD

Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, and tension before menstruation. The symptoms are far more severe than those seen with premenstrual syndrome and often disrupt work and relationships.

Drugs used to treat Premenstrual Dysphoric Disorder

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
fluoxetine 8.6 120 reviews for fluoxetine to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
fluoxetine systemic
Brand name:
Prozac
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Prozac 7.3 23 reviews for Prozac to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
fluoxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Zoloft 7.7 51 reviews for Zoloft to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
sertraline systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
sertraline 8.0 77 reviews for sertraline to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
sertraline systemic
Brand name:
Zoloft
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Yaz 7.2 131 reviews for Yaz to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
escitalopram Off-label 9.4 29 reviews for escitalopram to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
escitalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
bupropion Off-label 8.7 4 reviews for bupropion to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
bupropion systemic
Drug class:
miscellaneous antidepressants, smoking cessation agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
citalopram Off-label 8.9 28 reviews for citalopram to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
citalopram systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Beyaz 8.1 14 reviews for Beyaz to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol / levomefolate calcium systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
venlafaxine Off-label 9.5 4 reviews for venlafaxine to treat Premenstrual Dysphoric Disorder
Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
paroxetine 8.1 11 reviews for paroxetine to treat Premenstrual Dysphoric Disorder
Rx D N X
Generic name:
paroxetine systemic
Brand name:
Paxil CR
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Yasmin 5.6 22 reviews for Yasmin to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
drospirenone / ethinyl estradiol 6.5 248 reviews for drospirenone / ethinyl estradiol to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Brand names:
Yaz, Yasmin, Gianvi, Loryna, Nikki, Ocella, Syeda, Lo-Zumandimine, Jasmiel, Zarah, Zumandimine
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Paxil CR 9.0 3 reviews for Paxil CR to treat Premenstrual Dysphoric Disorder
Rx D N X
Generic name:
paroxetine systemic
Drug class:
selective serotonin reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Gianvi 6.8 29 reviews for Gianvi to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Loryna 4.2 15 reviews for Loryna to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
drospirenone / ethinyl estradiol / levomefolate calcium 7.9 15 reviews for drospirenone / ethinyl estradiol / levomefolate calcium to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol / levomefolate calcium systemic
Brand name:
Beyaz
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Nikki 5.2 31 reviews for Nikki to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Ocella 7.0 1 review for Ocella to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Syeda 8.0 1 review for Syeda to treat Premenstrual Dysphoric Disorder
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
acetaminophen / caffeine / pyrilamine 9.0 1 review for acetaminophen / caffeine / pyrilamine to treat Premenstrual Dysphoric Disorder
OTC N N X
Generic name:
acetaminophen / caffeine / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
acetaminophen / pamabrom / pyrilamine 0.0 1 review for acetaminophen / pamabrom / pyrilamine to treat Premenstrual Dysphoric Disorder
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Brand names:
Pamprin Maximum Pain, Menstrual Pain Relief, Premsyn PMS, Menstrual PMS
Drug class:
analgesic combinations
For consumers:
interactions, side effects
pamabrom 2.0 1 review for pamabrom to treat Premenstrual Dysphoric Disorder
OTC N N
Generic name:
pamabrom systemic
Brand names:
Aqua-Ban, Diurex Water Capsules, Diurex Aquagels
Drug class:
miscellaneous diuretics
For consumers:
interactions, side effects
Pamprin Maximum Pain Rate Add review
OTC N N X
Generic name:
acetaminophen / pamabrom / pyrilamine systemic
Drug class:
analgesic combinations
For consumers:
interactions, side effects
Lo-Zumandimine Rate Add review
Rx X N X
Generic name:
drospirenone / ethinyl estradiol systemic
Drug class:
contraceptives
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

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Alternative treatments for Premenstrual Dysphoric Disorder

The following products are considered to be alternative treatments or natural remedies for Premenstrual Dysphoric Disorder. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Premenstrual Dysphoric Disorder.

Learn more about Premenstrual Dysphoric Disorder

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.