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Drospirenone / Ethinyl Estradiol / Levomefolate Calcium Dosage

Medically reviewed on September 14, 2018.

Applies to the following strengths: 3 mg-0.02 mg-0.451 mg; 3 mg-0.03 mg-0.451 mg

Usual Adult Dose for Contraception

1 tablet orally each day. A patient should begin taking either on the first day of the menstrual period (Day 1 Start) or on the first Sunday after the onset of the menstrual period (Sunday Start). The patient should begin the next and all subsequent 28-day regimens on the same day of the week as she began the first regimen, following the same schedule.

Usual Adult Dose for Premenstrual Dysphoric Disorder

1 tablet orally each day. A patient should begin taking either on the first day of the menstrual period (Day 1 Start) or on the first Sunday after the onset of the menstrual period (Sunday Start). The patient should begin the next and all subsequent 28-day regimens on the same day of the week as she began the first regimen, following the same schedule. Drospirenone-ethinyl estradiol is indicated for the treatment of symptoms of premenstrual dysphoric disorder (PMDD) in women who choose to use an oral contraceptive as their method of contraception. The effectiveness of drospirenone/ethinyl estradiol/levomefolate for premenstrual dysphoric disorder when used for more than three menstrual cycles has not been evaluated.

Usual Adult Dose for Acne

1 tablet orally each day. A patient should begin taking either on the first day of the menstrual period (Day 1 Start) or on the first Sunday after the onset of the menstrual period (Sunday Start). The patient should begin the next and all subsequent 28-day regimens on the same day of the week as she began the first regimen, following the same schedule. Drospirenone-ethinyl estradiol is indicated for the treatment of moderate acne vulgaris in women at least 14 years of age, who have no known contraindications to oral contraceptive therapy and have achieved menarche. Drospirenone/ethinyl estradiol/levomefolate should be used for the treatment of acne only if the patient desires an oral contraceptive for birth control.

Renal Dose Adjustments

The medication is contraindicated in patients with renal insufficiency.

Liver Dose Adjustments

The medication is contraindicated in patients with hepatic dysfunction.

Precautions

US BOXED WARNING:
-CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS: Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke.

Safety and efficacy have been established in female patients of reproductive age; use prior to menarche is not indicated.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

It is recommended to take at the same time each day, preferably after the evening meal or at bedtime.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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