Generic name: Ethinyl Estradiol, Drospirenone, and Levomefolate [ ETH-in-il-es-tra-DYE-ole, droh-SPYE-re-none, & lee-voe-me-FOE-late ]
Brand names: Beyaz, Rajani, Safyral, Tydemy
Medically reviewed by Drugs.com. Last updated on Jan 6, 2023.
The Rajani brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
- Smoking cigarettes while using Rajani (ethinyl estradiol, drospirenone, and levomefolate) raises the chance of very bad heart and blood-related side effects. This chance is raised with age (mainly in women older than 35 years of age). It is also raised with the number of cigarettes smoked. It is strongly advised not to smoke. Do not use Rajani (ethinyl estradiol, drospirenone, and levomefolate) if you smoke and are older than 35 years of age.
Uses of Rajani:
- It is used to prevent pregnancy.
- It is used to treat premenstrual dysphoric disorder (PMDD).
- It is used to treat pimples (acne).
- Levomefolate is a vitamin used to aid the diet needs of women who may get pregnant.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Rajani?
- If you have an allergy to ethinyl estradiol, drospirenone, levomefolate, or any other part of Rajani (ethinyl estradiol, drospirenone, and levomefolate).
- If you are allergic to Rajani (ethinyl estradiol, drospirenone, and levomefolate); any part of Rajani (ethinyl estradiol, drospirenone, and levomefolate); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have had any of these health problems: Blood clots, blood clotting problem, breast cancer or other cancer where hormones make it grow, diseased blood vessels in the brain or heart, disease of a heart valve with problems, heart disease, chest pain caused by angina, heart attack, stroke, high blood pressure, liver disease, liver tumor, very bad headache or migraine, or diabetes that affects blood flow.
- If you have kidney disease.
- If you have adrenal gland problems.
- If you have had any of these health problems: Endometrial cancer, cancer of the cervix or vagina, or vaginal bleeding where the cause is not known.
- If you have surgery and need bedrest.
- If you turned yellow during pregnancy or with estrogen-based or hormone contraceptive use.
- If you are pregnant or may be pregnant. Do not take Rajani (ethinyl estradiol, drospirenone, and levomefolate) if you are pregnant.
- If you are breast-feeding or plan to breast-feed.
- If you are taking ombitasvir, paritaprevir, and ritonavir (with or without dasabuvir).
This is not a list of all drugs or health problems that interact with Rajani (ethinyl estradiol, drospirenone, and levomefolate).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Rajani (ethinyl estradiol, drospirenone, and levomefolate) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Rajani?
- Tell all of your health care providers that you take Rajani (ethinyl estradiol, drospirenone, and levomefolate). This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If Rajani (ethinyl estradiol, drospirenone, and levomefolate) is stopped, your doctor will tell you when to start taking Rajani (ethinyl estradiol, drospirenone, and levomefolate) again after your surgery or procedure.
- This medicine may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
- This medicine has the hormone drospirenone. The chance of blood clots may be greater with birth control that has drospirenone than with other birth control pills. Talk with the doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
- Check your blood sugar as you have been told by your doctor.
- If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
- High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Be sure to have regular breast exams and gynecology check-ups. You will also need to do breast self-exams as you have been told.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Rajani (ethinyl estradiol, drospirenone, and levomefolate).
- This medicine may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- Certain drugs, herbal products, or health problems could cause Rajani (ethinyl estradiol, drospirenone, and levomefolate) to not work as well. Be sure your doctor knows about all of your drugs and health problems.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors.
- Do not use in children who have not had their first menstrual period.
- If you have any signs of pregnancy or if you have a positive pregnancy test, call your doctor right away.
How is this medicine (Rajani) best taken?
Use Rajani (ethinyl estradiol, drospirenone, and levomefolate) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take Rajani (ethinyl estradiol, drospirenone, and levomefolate) at the same time of day.
- Take after the evening meal or at bedtime.
- Take with or without food. Take with food if it causes an upset stomach.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- Do not skip doses, even if you do not have sex very often.
- If you throw up or have diarrhea, Rajani (ethinyl estradiol, drospirenone, and levomefolate) may not work as well to prevent pregnancy. Use an extra form of birth control, like condoms, until you check with your doctor.
- If you miss 2 periods in a row, take a pregnancy test before starting a new cycle.
What do I do if I miss a dose?
- If a dose is missed, check the package insert or call the doctor to find out what to do. If using Rajani (ethinyl estradiol, drospirenone, and levomefolate) to prevent pregnancy, another form of birth control may need to be used for some time to prevent pregnancy.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Very upset stomach or throwing up.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very bad headache.
- Low mood (depression).
- Mood changes.
- Feeling very tired or weak.
- Not able to pass urine or change in how much urine is passed.
- A lump in the breast, breast pain or soreness, or nipple discharge.
- Vaginal itching or discharge.
- Spotting or vaginal bleeding that is very bad or does not go away.
- Bulging eyes.
- Change in eyesight.
- Loss of eyesight.
- Change in how contact lenses feel in the eyes.
- Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
What are some other side effects of Rajani?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling more or less hungry.
- Weight gain.
- Upset stomach or throwing up.
- Period (menstrual) changes. These include spotting or bleeding between cycles.
- Enlarged breasts.
- Tender breasts.
- Feeling tired or weak.
- Lowered interest in sex.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Rajani?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Rajani (ethinyl estradiol, drospirenone, and levomefolate), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
More about Rajani (drospirenone / ethinyl estradiol / levomefolate calcium)
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