Skip to Content

Rajani Side Effects

Generic Name: drospirenone / ethinyl estradiol / levomefolate calcium

Note: This page contains side effects data for the generic drug drospirenone / ethinyl estradiol / levomefolate calcium. It is possible that some of the dosage forms included below may not apply to the brand name Rajani.

In Summary

Common side effects of Rajani include: headache and spotting. Other side effects include: irregular menses and migraine. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet

As well as its needed effects, drospirenone / ethinyl estradiol / levomefolate calcium may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking drospirenone / ethinyl estradiol / levomefolate calcium, check with your doctor immediately:

More common:
  • Breast pain or tenderness
  • headache, severe and throbbing
  • heavy non-menstrual vaginal bleeding
  • irregular menstrual periods
  • nausea
  • normal menstrual bleeding occurring earlier, possibly lasting longer than expected
Less common:
  • Longer or heavier menstrual periods
  • unusual tiredness or weakness
  • vomiting
Incidence not known:
  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • dark urine
  • difficulty with breathing
  • dizziness
  • fever
  • headache
  • itching
  • loss of appetite
  • pain in the chest, groin, or legs, especially the calves
  • rash
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vision changes
  • vomiting of blood
  • yellow eyes or skin

Minor Side Effects

Some drospirenone / ethinyl estradiol / levomefolate calcium side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Crying
  • decreased interest in sexual intercourse
  • delusions of persecution, mistrust, suspiciousness, and/or combativeness
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • mental depression
  • quick to react or overreact emotionally
  • rapidly changing moods
  • weight gain

For Healthcare Professionals

Applies to drospirenone / ethinyl estradiol / levomefolate calcium: oral tablet


Cardiovascular side effects have included hypertension, arterial or deep venous thrombotic events, strokes, and myocardial infarctions.[Ref]


Genitourinary side effects have included breast tenderness, decreased libido, unscheduled (breakthrough or intracyclic) bleeding and spotting.


Gastrointestinal side effects have included nausea, vomiting, and inflammatory bowel disease.[Ref]


Hepatic side effects have included jaundice, cholestasis and hepatic adenomas.[Ref]


Metabolic side effects have included gallbladder disease, liver function disturbances, liver tumors, hyperkalemia, hypertriglyceridemia, changes in glucose tolerance, and effect on peripheral insulin resistance (including diabetes mellitus).[Ref]

Nervous system

Nervous system side effects have included an increase in frequency or severity of migraine headaches.[Ref]


Ocular side effects have included loss of vision, proptosis, diplopia, papilledema, or retinal vascular lesions.[Ref]


Psychiatric side effects have included irritability, depression and affect lability.[Ref]


Oncologic side effects have included carcinoma of the breasts and reproductive organs.[Ref]


Musculoskeletal side effects have included systemic lupus erythematosus.[Ref]


Dermatologic side effects have included chloasma, angioedema, erythema nodosum, and erythema multiforme.[Ref]


Hypersensitivity side effects have included anaphylactic reaction.[Ref]


1. "Product Information. Beyaz (drospirenone/ethinyl estradiol/levomefolate)." Bayer Pharmaceutical Inc, West Haven, CT.

It is possible that some side effects of Rajani may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Rajani (drospirenone / ethinyl estradiol / levomefolate calcium)

Consumer resources

Other brands: Beyaz, Safyral

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.