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Caplyta User Reviews & Ratings

Caplyta has an average rating of 6.3 out of 10 from a total of 152 reviews on Drugs.com. 53% of reviewers reported a positive experience, while 33% reported a negative experience.

Reviews for Caplyta

  • Saras...
  • Taken for 1 to 6 months
  • June 17, 2022

For Bipolar Disorder "Amazing so far. I have been on it for six weeks and after getting past the first three days taking it- which gave me awful headaches, nausea, dry mouth, and fatigue - I started to feel something in me change. After three weeks I can say I noticed that the typical bad, ruminating thoughts of despair and general negativity were decreasing. And now at six weeks I can honestly say I have days where I catch myself and think, “Wow— I haven’t thought anything bad today”. I have never had a med this effective, and have a very sensitive/resistant system that has made med therapy a chore because nothing ever seems to work, or I end up having bad side effects. For the first time in 25+ years I feel hopeful; I am finding real joy in things, laughing genuinely, and I am able to be more compassionate and realistic with the pressures I put on myself. It’s improving my outlook on life and in turn improving my relationships. This is a miracle med for me."

10 / 10
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206 Report
  • Caplyta...
  • Taken for less than 1 month
  • February 18, 2022

For Schizophrenia "I have had a very positive experience with Caplyta so far. I have been on several antipsychotics that worked but had side effects that were not tolerable. On the first day of taking this, I had dry mouth and a headache. Since then, I have not had a single side effect. After a week on it, I feel great. I haven't gained weight on it which is a good sign. I have more motivation and am sleeping normally after having those problems on Vraylar. My mood is also not flat like it was on the other medications that I had been on previously. I am not normally the person to write reviews but I saw all of the bad reviews and thought that maybe by sharing my experience it would help others. Maybe many people don't write reviews unless they have a bad experience? I am not sure but my experience on it has been very good. Would recommend to anyone who couldn't tolerate the side effects of other antipsychotics."

10 / 10
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129 Report
  • Feeling...
  • Taken for 1 to 6 months
  • September 6, 2020

For Schizophrenia "This medicine Caplyta has been a lifesaver for my bipolar! I've experienced sleepiness and dry mouth in the beginning, but those have gone away in the 5 weeks I've been on this medicine. My bipolar is completely under control and the severe depression is gone. I feel motivated, happy and able to participate in life. I'm so happy to have found this medicine. I finally feel 'normal'."

10 / 10
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170 Report

Frequently asked questions

  • Happy
  • Taken for 2 to 5 years
  • December 13, 2021

For Schizophrenia "I would often complain to my psychiatrist about how many meds I was taking for my schizoaffective bipolar. He'd always assure me that brains and meds are like locks and keys; sometimes you only need one key to open the lock, and other times you need multiple keys at once. I'm a multiple keys type of girl. I've been on a myriad of psych meds, but slowly found out that I needed several at once to keep things steady, but I still felt 'crazy'. I was angry, extremely paranoid, sleepy, hallucinating constantly, and I felt so unsafe in the world, like everyone was out to get me. I read about a new med coming out and begged my psychiatrist to let me take it. 'Okay, we'll see how it works for you,' he said. It was slow at first, or so I thought. I didn't realize the small changes that were happening. I became less angry, less paranoid. I stopped hallucinating. But most of all, I started to feel happy. I never realized life could be so peaceful."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • February 23, 2022

For Bipolar Disorder "Caplyta is my fifth trial antipsychotic, and the first one that has produced no side effects. I have noticed a substantial shift in my depression and mood. It has not completely alleviated all of my symptoms, but it is definitely helping. I take it in combination with Lamictal 300 and Divalproex 250."

9 / 10
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110 Report

Are you taking this medicine?

  • Anonymous
  • Taken for less than 1 month
  • April 16, 2022

For Bipolar Disorder "Here is a weird one. I've been on Caplyta for a week as of today. And I seem to embarrassingly lost bladder control. Yesterday I had 3 accidents and today I have had 3 as well! It hits out of nowhere that I have to go, and if I don't get to a toilet within a minute, I just go uncontrollably on myself. I can't stop it. I'm 32, haven't had a child in nearly 10 years. I don't know what could be causing this other than I've been on a new medicine. I'm so embarrassed. I'm a school bus driver; it happened today at the end of my route before I could make it back to the bus yard, and I soaked myself and the seat of the bus. I was so embarrassed on the walk to my car! Has anyone else had this happen?"

6 / 10
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  • Esbee
  • Taken for 1 to 6 months
  • March 24, 2023

For Bipolar Disorder "Caplyta is a game-changer!! For me, my bipolar depression is mostly compounded by my ADHD creating extremely low energy and so much restlessness. Because all other antipsychotics block the D1 dopamine receptor, they never help me beyond pulling me out of an acute hypomanic or mixed episode. Caplyta is a D1 and D2 agonist (promoter)!! It has been remarkable for keeping me level and helping with my depression without causing any weight gain whatsoever. Two months on it and I’ve lost everything I gained and more from when I was on abilify. Caplyta is my savior. It’s my miracle all-in-one. Please try it, and give it a few weeks."

10 / 10
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60 Report
  • RL84
  • Taken for less than 1 month
  • June 10, 2022

For Bipolar Disorder "I’m very early into taking this medication. About six days to be exact. I have BP1 disorder, generalized anxiety, and panic disorder. I have been on several different medications over the years. Currently, I take 450mg ER Lithium once in the AM and twice at night. Lamictal (brand name) 100mg once daily and 1mg Xanax 4x daily as needed. Speaking with my psychiatrist about my irritability and flat mood, we decided to give Caplyta a try. I was skeptical because of how new it is, not to mention seemingly bad reviews. That being said, the first night was a bit hairy. I would get unbelievably cold like I was in Antarctica with no clothes on. Then I would be burning up. A brutal headache ensued late and into the next day. I was considering not taking it the next day, but I decided to stick with it. I’m glad I did. The side effects were drastically less the next day and more or less gone completely, and I noticed a difference for sure (i.e., more engaged, better mood)"

9 / 10
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81 Report
  • BeePa...
  • Taken for 1 to 6 months
  • May 23, 2022

For Bipolar Disorder "My God, this medication has changed my life. I am able to separate my emotions from my logic. I'm not depressed or angry anymore. Is this what life is like for 'normal people'? I feel like I have hope in my life which I really haven't had before. I have bipolar 2 as well as C-PTSD. I take this alongside Lamictal, Celexa, and Prazosin (for PTSD nightmares). Whoever made this drug is a lifesaver. I've had side effects of dry mouth and felt an improvement within 2 weeks."

10 / 10
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  • apath...
  • Taken for 1 to 6 months
  • March 10, 2023

For Bipolar Disorder "I've been on Caplyta going on 4 months now. My depression has never been worse, I now have high blood pressure, dystonia, heartbeat irregularities, SEVERE constipation, severe anxiety, and broken sleep, about 10 hours a day. I've never felt this horrible on an antipsychotic med in my life before and I've been on most of them. I can't get out of bed to shower, do chores, do any self-care, cooking, clean, etc. These drugs' side effects are worse than any drug I've taken for my BP2 depression. I've almost landed in the ER for heart palpitations and high blood pressure and resting heart rate in the high 80s to low 90s. The amount of apathy I have is unlike anything I've experienced. It may work well for schizophrenia, but for my BP2 it is the worst drug I've ever taken in over 32 years. I would never recommend this drug to anyone for BP2 depression."

1 / 10
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  • Raychel
  • Taken for 1 to 6 months
  • March 11, 2022

For Bipolar Disorder "Caplyta made my depression worse. It was like I was in a black hole for a month. It got rid of my mania for sure. But the crushing depression made it a really bad choice for me. I will never take this again."

4 / 10
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75 Report
  • Val
  • Taken for 1 to 6 months
  • October 26, 2023

For Bipolar Disorder "Caplyta has changed my life. For many years, I took other antipsychotics and also tried lithium. They left me with tremors, gaining 75 pounds, suicidally depressed. I have bipolar type 1, sensory integration disorder, ADD, agoraphobia, OCD, and anxiety. On all previous mood stabilizers and antipsychotics, I had a flat mood, no real happiness. But still crushing bouts of depression. Also, I have never been able to keep my house clean. I often hoard. I have issues with keeping up my hygiene. I was full of self-doubts and paralyzed with fear. Just generally waiting to die. I have been tweaking the Caplyta, 42mg, with my other meds - Trintellix 20mg, buspirone 30mg, Rexulti 4mg, and clonazepam 2mg for sleep or as needed. I started taking Caplyta in late May. I felt it really kicked in September. My house is immaculate. I bathe every day. My intrusive thoughts/voices have significantly decreased. I rarely feel suicidal. I can leave my house alone. I have lost weight. I feel amazing!"

10 / 10
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31 Report
  • BubsD...
  • Taken for 1 to 6 months
  • November 10, 2021

For Schizophrenia "Absolutely GODSEND!!! I have been on every drug for my schizophrenia up to clozapine, and nothing worked without making me an emotionless drooling void. I have been on Caplyta for about three months, and my quality of life has improved exponentially. My schizo was so bad; I had, by and large, stopped all hygiene, never left the house, and was consumed by paranoia and voices that no one but me could hear. I am now extremely hygienic, I have set routines and schedules again, I am able to go out in public, I converse with complete strangers every day, and I am so optimistic and happy again. I am on no antidepressants anymore, my anxiety is much lessened, and am happy again."

10 / 10
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81 Report
  • Babyron
  • Taken for 1 to 6 months
  • February 12, 2022

For Bipolar Disorder "I’ve been taking Caplyta for almost a month for bipolar depression. I immediately felt better emotionally but have developed a perpetual need to yawn/take a deep breath and a tightness across my upper abdomen. I’ve also noticed tension in the front of my neck and chest. It is not ideal and I am constantly debating these pros and cons. I have more mental clarity than I have had in years, but I am aggravated by yawning or semi-nauseous."

7 / 10
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66 Report
  • delta...
  • Taken for less than 1 month
  • November 2, 2020

For Schizophrenia "I'm on Caplyta for schizoaffective, alongside lithium. It has helped me so much! I was struggling with a lot of intrusive non-realities and visuals, delusions relating to fears and paranoias, disconnection, overwhelming conversations in my head, and severe mood swings, which had been affecting me for years. It has gone a long, long way in helping these issues. My first week was a bit rough but not overwhelming. The first dose left me extremely drowsy, so I decided to take it in the evenings before bed. In the subsequent days, I did feel a bit of dread as it set in. Six days in, I felt like I was able to move it to the mornings and my body was getting used to it. Even before then, it helped me with my symptoms a lot. I really have to take it with food. I've had to eat fuller breakfasts since getting on it, or else the drowsiness comes back, but it's easily preventable. This medication has really changed my life, and I'd encourage anyone trying it to wait a week unless the side effects are too severe."

9 / 10
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90 Report
  • ejames
  • Taken for 1 to 6 months
  • June 17, 2022

For Bipolar Disorder "Doctor started me on this new medicine as an adjunct to the other medications I take. It took around 2 weeks to notice any real effects from this drug. Caplyta certainly did lift my mood but I did have to come off of this drug due to the side effects. This is a relatively new drug and I don’t think many of the side effects are documented well. I stopped because Caplyta made me lose control of my bladder, and it made me feel like I had to go to the bathroom all the time. This was to the point where I got tested for a UTI (negative). I also got shooting pains in my rib cage near my upper chest. I’m not saying it’s a bad drug, just feel it out and listen to your body."

6 / 10
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56 Report
  • Fuh_Khu
  • Taken for less than 1 month
  • March 17, 2022

For Bipolar Disorder "I started this Med a couple days ago. I feel ok. Extreme dry mouth. Literally woke up in the night to chug milk, water & Oj. That being said, I usually can only sleep 90 minutes per each time I fall asleep thru the night. I’ve been sleeping 3-5 hours each time the last couple nights, and for first time in years feeling like I’ve had some rest when I awake. For years crawling out of bed in am, I felt like I had had the crap beat out of me. The only side affect I’m worried about is the weight gain. But I will continue to work with Dr to see if we can make a go of this. I’ve tried many meds over the years. This is the only one I have hope for as the others made me crazier, want to gamble and one had me so zombied I was going to Jack in the box every night for like 200 mini churros."

9 / 10
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61 Report
  • SurfMan
  • Taken for 1 to 6 months
  • September 28, 2020

For Schizophrenia "I have Schizophrenia. After four years and as many different prescriptions, a 30+ lb weight gain, and blood glucose & cholesterol levels off the charts, my doctor prescribed the new drug, Caplyta. It's been five weeks and I've lost 2 lb. In addition, my sleep, sex drive, and well-being are feeling restored to a level I’d nearly forgotten and haven't been at since my mid-20s. Looking forward to the follow-up blood work in two months."

9 / 10
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83 Report
  • Anonymous
  • Taken for less than 1 month
  • June 24, 2020

For Schizophrenia "I've had very few side effects so far. This med, Caplyta, doesn't make me feel like a zombie like the other meds, and I can think more clearly. The only side effects I've experienced are mild nausea and internal restlessness. I'll have to see how the next upcoming doses go."

7 / 10
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87 Report
  • Corpo...
  • Taken for less than 1 month
  • August 1, 2020

For Schizophrenia "I took one dosage of Caplyta and about 20 minutes in my arms and legs started to burn as if I took a niacin. Then the next day I had a searing headache. If this drug works for some, great. But not for me. I couldn't find any of my side effects on the internet."

1 / 10
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85 Report
  • Mandy...
  • Taken for 1 to 6 months
  • August 28, 2023

For Bipolar Disorder "I would ignore these negative reviews. They seem to be people who only stayed on the drug for a couple days. I have bipolar depression. 11 months ago I was hit with the worst depression of my life. I couldn't get off my bed or off the couch. I slept a ton. My house was trashed for months. My doctor wanted me to try caplyta. Now. The first day I took it, it was horrifying. I took it at night and woke up in the middle of the night with the worst throbbing headache I have ever had. ER worthy. I rushed to take a 800mg ibuprofen and that only cut the pain down in half. A few hours after I went to bed after being awoken by a headache, I woke up in the am. I felt completely drunk. I couldn't walk straight, bumping into walls. Etc. I will tell you. After the first day of taking this med, the next day I had no symptoms. No headache, I did feel a little wobbly, but not as bad as the first day. 3rd day, no side effects. The 3rd day is when my depression completely vanished. Amazing"

10 / 10
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27 Report
  • KDO
  • Taken for 1 to 6 months
  • October 17, 2021

"I’ve been taking Caplyta (42mg) for 5 months now for my Bipolar 1. For the past ten years I have cycled hard between depression and mania (hypomania). I have been on many different medications. The 5 months since taking Caplyta I haven’t been depressed or manic once. My mind is clear, no fog. My energy levels have been up and zero side effects."

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58 Report
  • tex
  • Taken for 1 to 6 months
  • June 29, 2022

For Bipolar Disorder "I'm currently on Caplyta 42mg and have been for over 3 months. It has vastly improved my life and allowed me to get back to a normal version of myself. I've tried several other atypical antipsychotics like Latuda, Vraylar, and Geodon, each with varying success. Vraylar was the best antipsychotic I was on, sadly it quit working. Caplyta has gotten closer to the stability I had with Vraylar. However, I understand that every person has different success with different medications so do not compare my experience to others. Caplyta though is very expensive and with my insurance switching in the coming months, I may be forced to switch once again which I do not want due to the success of Caplyta. I've had no noticeable side effects from this medication and it does not interact with my other medications prescribed which is a major advantage."

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  • Yolo
  • Taken for less than 1 month
  • May 20, 2022

For Bipolar Disorder "I have been on Caplyta for a week and 2 days. I have been so hopeful for 6 years now that a new medication could help with my depression. I've had a bipolar 1 diagnosis for almost 20 years now. Abilify was life changing for me. It worked for me all on its own for about 12 years!! But it stopped working. I like to run a little hypomanic. Which is where I find myself right now. However, I have also stopped my wellburtrin and tapered off abilify all within a week too. First few days of Caplyta I was exhausted around the clock. I also have very vivid dreams. The tiredness gets better each day. I haven't experienced anything else physically. I am exercising again, I am writing again and I am hopeful. So its definitely working for me so far!"

9 / 10
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  • THano
  • Taken for 1 to 6 months
  • December 13, 2020

For Schizophrenia "I felt burning the first day on Caplyta and it continued the whole time. Hair loss started in about two weeks and that was before the medicine became really intense. I couldn't stop talking, couldn't sleep, and couldn't stop moving. My throat became very sore from talking so much. I felt like I had to walk to settle my mind. I could sleep for about an hour or two a night for about the last 3 weeks on the medication. My hallucinations became terrifying to me. This was like a whole other level of my nightmare life. It was like living in an insane world. Watching TV was terrifying. I felt like I was being hunted by people at night. Urinating became painful and I felt like I wanted to scream. There was difficulty in urinating from the pressure. I was also hallucinating more. 6 1/2 months after stopping the medication, I'm still trying to recover. It was a nightmare."

1 / 10
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65 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.