How long does it take Caplyta to work?

Patient with schizophrenia started to show improved Positive and Negative Syndrome Scale (PANSS) total scores after one week of treatment with Caplyta (lumateperone), according to the results of a phase III trial. PANSS is a scale used to measure the severity of schizophrenia symptoms. Symptoms continue to improve the longer you take the drug.

While there may be some signs of improvement during the initial weeks of treatment, it can take up to 2-3 months for the full effects to be felt in patients with schizophrenia.

In the first 1-2 weeks, hallucinations, disorganized thinking and delusions may improve, although sometimes they won’t go away altogether. It can also take at least 1-2 weeks for motivation and the desire to be around other people to improve.

Patients with bipolar depression also started to show improvement in their symptoms during the initial weeks of treatment with Caplyta, according to the results of another phase III trial. At the end of the 6 week trial, patients with bipolar depression treated with Caplyta 42mg day showed a statistically significant improvement in their symptoms compared with patients receiving placebo.