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How long does it take for Vraylar (cariprazine) to work?

Medically reviewed by Drugs.com. Last updated on Jul 27, 2020.

Official Answer

by Drugs.com

Vraylar (cariprazine) takes time to work and patients often see a gradual reduction in symptoms over several weeks. Symptoms tend to continue to improve the longer the medication is taken. Some symptoms may not completely resolve however. Vraylar is an atypical antipsychotic used in the treatment of schizophrenia, the acute treatment of manic or mixed episodes associated with bipolar I disorder and the treatment of depressive episodes associated with bipolar I disorder. 

How long does Vraylar take to work in patients with schizophrenia?

  • Within the first 1-2 weeks hallucinations, disorganized thinking and delusions may improve.
  • After 1-2 weeks patients may feel more motivated and have a greater desire to be around other people.
  • After 6 weeks, patients with schizophrenia treated with Vraylar in a clinical trial saw a significant reduction in symptoms compared with patients who received placebo.
  • After 8-12 weeks of taking Vraylar, patients will likely see the full benefit of the treatment they will achieve.

How long does Vraylar take to work in patients with manic or mixed episodes associated with bipolar I disorder?

  • After 3 weeks, patients with manic or mixed episodes associated with bipolar I disorder treated with Vraylar in clinical trials saw significant reduction in symptoms compared with patients who received placebo.

How long does Vraylar take to work in patients with depressive episodes associated with bipolar I disorder (bipolar depression)?

  • After 6 weeks, patients with schizophrenia treated with Vraylar 1.5mg in clinical trials saw a significant reduction in symptoms compared with patients treated with placebo.
References
  • Food and Drug Administration (FDA). Vraylar. Highlights of Prescribing Information. [Accessed July 27. 2020]. Available online at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204370s006lbl.pdf.
  • National Alliance on Mental Illness (NAMI). Cariprazine (Vraylar). [Accessed July 27, 2020]. Available online at: https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Cariprazine-(Vraylar)#:~:text=Your%20doctor%20can%20best%20discuss,on%20your%20symptoms%20and%20illness.&text=Symptoms%20continue%20to%20get%20better,the%20full%20benefit%20of%20cariprazine.
  • Citrome L. Cariprazine in Schizophrenia: Clinical Efficacy, Tolerability, and Place in Therapy. Adv Ther (2013) 30(2):114–26. DOI 10.1007/s12325-013-0006-7.
  • Vieta E, Durgam S, Lu K, et al. Effect of cariprazine across the symptoms of mania in bipolar I disorder: Analyses of pooled data from phase II/III trials. Eur Neuropsychopharmacol. 2015 Nov;25(11):1882-91. DOI: 10.1016/j.euroneuro.2015.08.020.

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