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Vraylar - What are some of the important warnings?

Medically reviewed by Last updated on May 28, 2019.

Official Answer


Vraylar (cariprazine) is an antipsychotic medication that is used to treat schizophrenia and bipolar disorder. Vraylar may cause serious side effects including the increased risk of death in elderly people with dementia related psychosis. It may also increase the risk of suicidal thoughts or actions in children and young adults.

Warnings include:

  • Increased risk of death in older adults with dementia-related conditions;
  • Increased risk of suicidal thoughts or actions in children and young adults;
  • Increased risk of cerebrovascular disease, such as a stroke or transient ischemic disease (TIA), in elderly patients with dementia-related psychosis;
  • Elevated risk of neuroleptic malignant syndrome;
  • Possible risk of tardive dyskinesia;
  • Long-half life of drug requires side effect monitoring for several weeks at onset of therapy or after dose change;
  • Monitor for metabolic changes like high blood sugar, diabetes, weight gain and elevated lipids like cholesterol, LDL, and HDL;
  • Possible increased risk of orthostatic hypotension which may lead to fainting and falls.


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