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Generic name: lumateperoneLOO-ma-TE-per-one ]
Drug class: Atypical antipsychotics

Medically reviewed by Judith Stewart, BPharm. Last updated on Aug 22, 2023.

What is Caplyta?

Caplyta (lumateperone) is used in adults to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).

Caplyta is also used alone or with lithium or valproate to treat depression associated with bipolar disorder (manic depression).

Caplyta belongs to a class of medications called atypical antipsychotics. The exact way lumateperone works is unknown but it is thought to change the activity of certain natural substances in the brain.

Caplyta side effects

Get emergency medical help if you have signs of an allergic reaction ro Caplyta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

High doses or long-term use of Caplyta can cause a serious movement disorder that may not be reversible. The longer you use Caplyta, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Caplyta may cause serious side effects. Call your doctor at once if you have:

Common Caplyta side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking this medicine

You should not use Caplyta if you are allergic to lumateperone.

Lumateperone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

To make sure Caplyta is safe for you, tell your doctor if you have ever had:

Taking antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.

You should not breastfeed while using Caplyta.

This medicine may affect fertility (your ability to have children), whether you are a man or a woman.

How should I take Caplyta?

Take Caplyta as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

The recommended dose is one Caplyta 42mg capsule taken once a day with or without food.

Your treatment may also include weight control, and frequent medical tests.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Schizophrenia:

42 mg orally once a day

Use: For the treatment of schizophrenia

Usual Adult Dose for Bipolar Disorder:

42 mg orally once a day

Use: As monotherapy or as adjunctive therapy with lithium or valproate, for the treatment of depressive episodes associated with bipolar I or II disorder (bipolar depression)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Caplyta?

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.


Caplyta is not approved for use in older adults with dementia-related psychosis. Caplyta can increase the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

What other drugs will affect Caplyta?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can interact with lumateperone, especially:

This list is not complete and many other drugs may interact with lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.


Active ingredient: lumateperone.
Inactive ingredients: croscarmellose sodium, gelatin, magnesium stearate, mannitol, and talc. Colorants include FD& C blue #1 and red #3 (42 mg), FDA/E172 black iron oxide, FDA/E172 red iron oxide and FD& C red #3 (10.5 mg), and titanium dioxide (42 mg, 21 mg and 10.5 mg).


Distributed by: Intra-Cellular Therapies Inc., New York, NY 10016, USA.

Popular FAQ

Caplyta (lumateperone) should be taken once a day with or without food. The recommended dosage is one 42mg capsule a day. Caplyta can cause somnolence and sedation, but these side effects are reported less frequently when Caplyta is taken in the evening.

Patient with schizophrenia started to show improved Positive and Negative Syndrome Scale (PANSS) total scores after one week of treatment with Caplyta (lumateperone), according to the results of a phase III trial. PANSS is a scale used to measure the severity of schizophrenia symptoms. Symptoms continue to improve the longer you take the drug. Continue reading

Caplyta (lumateperone) treatment is not associated with the weight gain that some other antipsychotic drugs are. Caplyta is an atypical antipsychotic that is used to treat schizophrenia and bipolar depression in adults. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Caplyta only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.