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Medications for Overactive Bladder

Other names: bladder dysfunction; OAB

Medically reviewed by Carmen Pope, BPharm. Last updated on Mar 14, 2024.

Medications used to treat overactive bladder may include those that relax the bladder such as oxybutynin, which can be taken as a pill (Ditropan XL) or used as a skin patch (Oxytrol), or gel (Gelnique); darifenacin (Enablex); fesoterodine (Toviaz); mirabegron (Myrbetriq); solifenacin (Vesicare, Vesicare LS); tolterodine (Detrol, Detrol LA); trospium; and vibegron (Gemtesa). For postmenopausal women, estrogen treatment in the form of vaginal estrogen creams (such as Premarin Vaginal) or estrogen patches (such as Climara, Dotti) can help strengthen the muscles and tissues in the urethra and vaginal area, improving symptoms of overactive bladder.

Injections of onabotulinumtoxinA (Botox) into the bladder can help reduce severe urge incontinence by relaxing the muscles and increasing bladder capacity.

Drugs used to treat Overactive Bladder

The medications listed below are related to or used in the treatment of this condition.

Filter
Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Gemtesa 7.5 142 reviews for Gemtesa to treat Overactive Bladder
Rx N
Generic name:
vibegron systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
solifenacin 4.2 19 reviews for solifenacin to treat Overactive Bladder
Rx C N
Generic name:
solifenacin systemic
Brand name:
VESIcare
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
vibegron 7.5 148 reviews for vibegron to treat Overactive Bladder
Rx N
Generic name:
vibegron systemic
Brand name:
Gemtesa
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
onabotulinumtoxinA 6.5 12 reviews for onabotulinumtoxinA to treat Overactive Bladder
Rx C N
Generic name:
onabotulinumtoxinA systemic
Brand name:
Botox
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
VESIcare 5.0 4 reviews for VESIcare to treat Overactive Bladder
Rx C N
Generic name:
solifenacin systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Botox 6.5 12 reviews for Botox to treat Overactive Bladder
Rx C N
Generic name:
onabotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
darifenacin 4.5 2 reviews for darifenacin to treat Overactive Bladder
Rx C N
Generic name:
darifenacin systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
oxybutynin Rate Add review
Rx/OTC B N X
Generic name:
oxybutynin systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
estradiol Rate Add review
Rx X N
Generic name:
estradiol systemic
Drug class:
estrogens
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
estradiol Rate Add review
Rx X N
Generic name:
estradiol topical
Drug class:
estrogens, miscellaneous vaginal agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
tolterodine Rate Add review
Rx C N X
Generic name:
tolterodine systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
fesoterodine Rate Add review
Rx C N
Generic name:
fesoterodine systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
mirabegron 8.0 1 review for mirabegron to treat Overactive Bladder
Rx C N
Generic name:
mirabegron systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
trospium Rate Add review
Rx C N X
Generic name:
trospium systemic
Drug class:
urinary antispasmodics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information

Frequently asked questions

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Learn more about Overactive Bladder

Care guides

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.