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Trospium Side Effects

In Summary

Commonly reported side effects of trospium include: constipation and xerostomia. Other side effects include: headache, xerophthalmia, and dry nose. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trospium: oral capsule extended release, oral tablet

Along with its needed effects, trospium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trospium:

More common
  • Bladder pain
  • bloody or cloudy urine
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or burning urination
  • difficulty in passing urine (dribbling)
  • frequent urge to urinate
  • lower back or side pain
  • painful urination
Less common
  • Chills
  • cough
  • diarrhea
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • changes in vision
  • clammy skin
  • confusion as to time, place, or person
  • dark-colored urine
  • difficulty with swallowing
  • dizziness
  • enlarged pupils
  • fainting
  • fast or slow heartbeat
  • hallucinations
  • hives
  • holding false beliefs that cannot be changed by fact
  • increased sensitivity of the eyes to light
  • increased sweating, possibly with fever or cold
  • itching
  • muscle cramps or spasms
  • muscle stiffness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • severe chest pain
  • severe headache
  • shortness of breath
  • skin rash
  • sores, ulcers, or white spots in the mouth or on the lips
  • stiff or sore neck
  • tightness in the chest
  • unusual excitement, nervousness, or restlessness
  • wheezing

Some side effects of trospium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • blurred vision
  • difficulty having a bowel movement (stool)
  • dry mouth
  • dry skin
  • sleepiness or unusual drowsiness
Less common
  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • dry eyes
  • excess air or gas in the stomach or intestines
  • heartburn
  • indigestion
  • passing gas
  • stomach discomfort, upset, or pain
  • stuffy nose
  • trouble with urinating
  • unable to have a bowel movement (stool)
  • upper stomach pain
Incidence not known
  • Burning feeling in the chest or stomach
  • change in taste
  • dry throat
  • indigestion
  • loss of taste
  • swelling of the abdomen or stomach area
  • tenderness in the stomach area

For Healthcare Professionals

Applies to trospium: oral capsule extended release, oral tablet


Cardiovascular side effects including palpitations, supraventricular tachycardia, chest pain, and hypertensive crisis have been reported during postmarketing experience.[Ref]


Gastrointestinal side effects most commonly reported have included dry mouth (20.1% to 21.8%), constipation (9.5% to 9.6%), and abdominal pain (3.1%). Abdominal distention, dry throat, upper abdominal pain, aggravated constipation, dyspepsia, vomiting, dysgeusia, and flatulence have been reported in less than 2% of patients. Gastritis has been reported during postmarketing experience. At least one case of abdominal cramps has also been reported.[Ref]

Nervous system

Nervous system side effects have included headache (4.2%). Nervous system side effects reported postmarketing have included dizziness, confusion, hallucinations, and somnolence.[Ref]


Renal side effects have included urinary retention.[Ref]


Ocular side effects have included dry eyes and blurred vision. Abnormal vision has been reported during postmarketing experience.[Ref]


Psychiatric side effects including hallucinations and delirium have been reported during postmarketing experience.[Ref]


Other side effects have included fatigue.[Ref]


Dermatologic side effects have included dry skin. Rash has been reported during postmarketing experience.[Ref]


Hypersensitivity side effects including anaphylactic reaction have been reported during postmarketing experience.[Ref]


Metabolic side effects including rhabdomyolysis have been reported during postmarketing experience.[Ref]


Immunologic side effects including Stevens-Johnson syndrome have been reported during postmarketing experience.[Ref]


1. "Product Information. Sanctura (trospium chloride)." Odyssey Pharmaceutical, East Hanover, NJ.

2. Lopez Pereira P, Miguelez C, Caffarati J, Estornell F, Anguera A "Trospium chloride for the treatment of detrusor instability in children." J Urol 170 (2003): 1978-81

3. Epstein BJ, Gums JG, Molina E "Newer agents for the management of overactive bladder." Am Fam Physician 74 (2006): 2061-8

Some side effects of trospium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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