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User Reviews for Estradiol

Also known as: Estrace, Estradiol Patch, Climara, Delestrogen, Divigel, Vivelle-Dot, Estrogel, Femring, Minivelle, Dotti, Evamist, Depo-Estradiol, Menostar, Estraderm Lyllana Elestrin Alora Estra Pellets …show all brand names

Estradiol has an average rating of 6.0 out of 10 from a total of 396 ratings on Drugs.com. 50% of those users who reviewed Estradiol reported a positive effect, while 35% reported a negative effect.

Condition Avg. Rating Reviews Compare
Postmenopausal Symptoms  
6.1
320 reviews 157 medications
Oophorectomy  
4.8
34 reviews 35 medications
Primary Ovarian Failure  
6.8
13 reviews 36 medications
Hypoestrogenism  
4.4
12 reviews 37 medications
Atrophic Vaginitis  
5.6
11 reviews 54 medications
Gender Dysphoria  Off-label
10.0
4 reviews 6 medications
Atrophic Urethritis  
10.0
1 reviews 46 medications
Prostate Cancer  
9.0
1 reviews 55 medications
Summary of Estradiol reviews 6.0 396 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Estradiol

kd May 2, 2021

Dotti (estradiol) for Postmenopausal Symptoms: “I switched pharmacy and was given the Dotti patch rather than the Sandoz patch like I had before. Immediately my energy level dropped, chills, headache and drenching night sweats. This is not for me!”

1 / 10
Anonymous · Taken for 10 years or more April 30, 2021

Climara (estradiol) for Postmenopausal Symptoms: “Had a complete hysterectomy at 40 years old and have been on the patch for 23 years. It has been a lifesaver. Docs have tried to wean me off of it and menopause symptoms came back within 2 days. Sweating, mood swings/irritability, can't sleep, overall misery. Being on the patch, I feel close to normal and have good skin for 63 years old. I went off the patch for a week and had to get back on as quality of life was horrible without it. I felt best on .5 and was on it for 20 yrs but Doc reduced the dosage to .375 and wants me to be off them permanently because they claim it's risky for cardiovascular health (even though it's supposed to be good for bone health).”

9 / 10
doodlebuggi April 19, 2021

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “Sandoz patch... I don't find it effective AT ALL. If I use the whole patch it's like someone gave me speed for about 4-5 hours it had a super racy heart, super wound up, then.. nothing. The speedy feeling has made me remove the patch. Cut the 0.5 patch in half. Doesn't feel like it's doing anything particularly? WHY DOES THE US NOT SELL ESTRADOT? It is MADE IN THE US! Oh, and what is it with the PERMANENT red marks????? Take a patch off and there's a red mark that is taking weeks and weeks to go way (if it does at all). It's like it's been tattooed to my skin. In 18 months of estradot NEVER had that problem. Never had a sticking problem. Or a tolerance problem, just an acquiring problem - which again, is completely idiotic.. the boxes I got were labeled right on them "made in the USA" but they're SOLD in Australia. Why can't I get a US made medication IN the actual US??????? And why does it cost me a third to buy it elsewhere than any of these US acquirable patches cost?????”

1 / 10
Anonymous June 6, 2014

Estrace (estradiol) for Postmenopausal Symptoms: “Love it, no hot flashes or mood changes and feel like having sex again. Breasts have enlarged but are not painful. Taking 1 mg tablets, hope I never have to give up my wonder pill. Have been taking it for years and I am 70 years old.”

10 / 10
Rosie B · Taken for 1 to 6 months January 3, 2021

Estradiol Patch (estradiol) for Primary Ovarian Failure: “I’m 60 and had my ovaries removed 11 months ago. So for 5 months I have been using a new bio identical biest estriol & estradiol prescription along with progesterone gel. My hot flashes were bad, my vaginal irritation was unbearable. I Changed to estradiol gel and progesterone gel. My Hot flashes got so severe and vaginal irritation was so unbearable. I Finally decided to try the estradiol 0.075 patch changing 2 times a week. In just 2 days saw incredible improvement in hot flashes, mood energy, motivation, emotional mood. It gave me relief from all my symptoms. The brand I was given is manufactured by Mylan, which was given absolutely horrible low reviews. I was scared it wasn’t going to work for me, but decided to try it anyway because I was so very miserable. Can’t tell you how much relief I am feeling being in the patch and taking the progesterone micronized 100 mg pill. It’s been a lifesaver for me.”

10 / 10
Khatgirl · Taken for 2 to 5 years June 7, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I've been using these patches for several years now. They work much better than the pills did. Once in a great while I would have one unstick a day or 2 early, so I would just replace it with the next one in the box. But due to the pandemic, I got a 3 month supply, and they are drastically not sticking (even after 4 days), and I am short 2 weeks before my insurance is willing to refill my script again. And my last one completely fell off this morning! Mylan needs to get a better adhesive for these. (I would give the drug a 10 rating if it stayed on)”

7 / 10
Donna · Taken for less than 1 month August 5, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “The Sandoz brand estradiol patch is absolute garbage. It stops working for me after about 6-8 hours, and it's supposed to last 7 days. My gyn told me to prep skin with acetone ( !!! ) and to dry skin with hair dryer then apply patch and hold 10 seconds. Women deserve better than this rubbish - in all forms, from having to apply acetone to skin, to patches that don't live up to what they're supposed to do.”

1 / 10
loribean February 19, 2016

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “this medication saved my life...I actually like the mylan better than the vivelle as far as the way I feel, the vivelle caused sinus problems and gassy bloat, the mylan product did not for me, however the mylan product doesn't stick as well or last as long....OVERALL: I love estrogen replacement and it is a TRAGEDY that women are suffering and their docs are not offering HRT when it is now proven that HRT prolongs life and has a protective influence on heart, bones and brain. I want to tell every woman out there do not be a hero, do not suffer, and do not be afraid. estrogen is good for you and can give you your life back. why do none of the women I talk to know this? crime!!”

10 / 10
Dish79 January 29, 2014

Climara (estradiol) for Postmenopausal Symptoms: “Insomnia, night sweats, moody, uncontrollable crying in the bosses office! I tried so hard and so long to do nothing and let it runs it's natural course. If I didn't work and could take naps, I'd still suffer and deal with it. Not the case. Have to be on my toes at work. Quality of life was bad. Climara saved my life. It was a tough decision but I tell you, it works. I feel human again!”

10 / 10
Ray August 22, 2020

Divigel (estradiol) for Postmenopausal Symptoms: “I have used Divigel for many years and am now in my 70's. I am in good condition for my age. I am active taking care of my house and yard, feeling good and sleeping well. My new NP gynecologist says I have to go off the Divigel because I am on Eliquis for AFib and the two are at odds with each other. No other dr has mentioned this. I do not agree with this recommendation and am looking for a new doctor. The dr who prescribed Divigel is retiring. I don't mind taking a lower dose but when everything is doing well WHY do I stop the med that saved my life? I'm mad and I'm not going to take it. Just because you are in your 70's does not mean you should dry up and die. I think that the NP was mad that I looked so good for my age...she was in 60's. So that is my story for now....Divigel has saved my life after a hysterectomy in my 40's with ovaries remaining. I had menstrual problems all of my life until the surgery and subsequent Divigel HRT therapy.”

10 / 10
Anonymous · Taken for less than 1 month September 9, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “Used Sandoz brand for the first 8 estradiol patches. No problem. Pharmacy switched to Mylan, a horrible experience. I use twice a week. After the first 2 days, it starts to itch and turn red. Burning sensation by day 3 and its hard to remove and leaves deep red burn marks and continues to itch for a week. Marks remain on my body for over a month now. Not recommended!”

1 / 10
Lili · Taken for 1 to 6 months February 20, 2021

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “My biggest concern is that I am not getting the relief of post menopause even though I am using 0.1mg patch because the patch does not stay on your skin. I have been using the estradiol patch for many years. I was using Vivelle Dot until it was not covered by my insurance and switched to Mylan labs. It would be nice if these patches could stay on my skin to rate the effectiveness of the medication.”

2 / 10
Tiger · Taken for 2 to 5 years December 23, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I was put on the minivelle patch several years ago. It worked great. A year ago my pharmacy changed to this estradiol patch made by Mylan. I didn't notice until I used it. The patch does not stay on, but the worst part is what it does to my skin. I have horrid red patches that hurt and itch. And, they do not go away. Now I am having trouble finding a place to place the patch because I am covered in the scars from using this brand. I use CVS pharmacy. they told me they cannot get the patch which is why they switched to Mylan. I am contacting Noven to see what is going on. I see my doctor next month. I cannot continue using this product. It is horrible.”

1 / 10
Donna · Taken for less than 1 month September 27, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “Following up to my August 5, 2020 review of the Sandoz patch. My gyn switched me to a twice weekly patch - Mylan. This brand is worse than Sandoz. I applied a patch Friday night, and by Saturday evening I was sweating profusely. This is the second week on the Mylan patches. Again, women deserve better than being Guinea pigs for cheap drug companies.”

1 / 10
Momma can cook · Taken for 5 to 10 years March 13, 2017

Vivelle-Dot (estradiol) for Postmenopausal Symptoms: “I experienced an extreme menopause at 50: hot flashes, crying, brain fog, night sweats for 4 years. My female GYN would not prescribe HRT. My family committed me to a mental institution. I refused to take psych drugs. Afterward I followed up with a neuro-psychologist who agreed to have my primary care Dr. prescribe Vivelle.dot. Increasing it to 1.0 relieved me of all those horrible symptoms! I have used it for 5 years along with generic (TEV) premarin. A book which saved my life (besides THE BIBLE) is "OUTLIVING YOUR OVARIES" by Dr. Marina Johnson. She rescues women in menopause and men in andropause through hormone replacement therapy! I gave copies to several doctors and stressed to them the NEED for classes on menopause!”

10 / 10
FLKat · Taken for 1 to 6 months October 24, 2013

For Postmenopausal Symptoms: “Estradiol oral 5mg is the best decision I could have made. It was with much consideration due to all the bad press for hormone replacement in the past decade. I work full time, have a home and a life, I had to find something, nothing "natural or organic" was working. I started suffering night sweats 5 years ago, daytime hot flashes began 3 years ago. I was not sleeping through the night, tossing off the covers then putting them back on. I was exhausted, moody, and snarky. Within a month of starting Estradiol, I was sleeping soundly, the hot flashes were manageable, and not nearly as frequent. I'll use it for a year as prescribed and then take guidance from my doctor, but I truly am a new person.”

10 / 10
Anonymous · Taken for less than 1 month May 11, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I just started using the Mylan Estradiol patch after using the gel. I wanted to try something more user friendly than the gel though the gel worked well. I have had the same terrible skin reactions to the patch as I’ve seen commented on this site. I called Mylan to file a product complaint and plan to do so with the FDA as well. I will ask my doctor to write for another type of patch.”

3 / 10
Mert · Taken for 10 years or more January 22, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I’ve used lots of different patches over the years. My favorites have been the Vivelle Dot and the Sandoz patch. The Mylan estradiol patch is worthless - you’re supposed to wear it a week, but it only stays on lasts a day or two, it smells, and it causes skin irritation. Unfortunately, it’s the only one that I know that my insurance will pay for. I’ve been using Sandoz, but have to pay $65 a month for it. Does anybody have a suggestion on a patch estrogen that Priority Health pays for?”

10 / 10
Thought I was going crazy November 8, 2020

Vivelle-Dot (estradiol) for Postmenopausal Symptoms: “I would not recommend generic estradiol patch by mylan, it is total waste of money. I was given Vivelle dot after surgery. It worked great, the brain fog & the mood swings disappeared, I could tolerate myself & my family. My husband & kids would tell me, I seemed happier. I really felt like a brand new person. Over the years the cost even with insurance just gradually going up & now my insurance doesn't pay at all. So the pharmacy switched me to (mylan) the generic. This patch wouldn't stay on for more than a couple of hours before having to tape it on. The feelings of being on edge, anxiety, mood swings, anger, fatigue & hot flashes were unbearable. Vivelle dot by Novartis is the only one I have found that I can take. I'm now having to have my Dr put brand name only so the pharmacy will fill it & I have to pay out of pocket for them at 206$ a box. The pharmacist keep trying to switch me back to generic, I keep telling them it's like throwing money away if it doesn't work.”

10 / 10
Ruthie · Taken for less than 1 month June 5, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I used to use Climara. Great option. After I changes insurance I had to use a Mexican brand that worked really well. After I moved to another state I had to get a US brand. I was give Mylan Estradiol patches and after 2 days or less they fall off. I just feel I wasted my money and they are not cheap.”

1 / 10
Ali · Taken for 1 to 6 months October 9, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “I have been on Vivelle Dot for 8 years. Love it and no issues at all. I cannot find it anymore and have checked several pharmacies. I had to switch to Mylan generic. Absolutely awful. It does not stick well and comes off. It leaves red marks on my skin and is itchy. I do not feel I am getting the same amount of hormones and my body can tell the difference. I have used it for 2 months. The patch is supposed to last 3 1/2 days and I am sometimes changing after 2 days. Not happy with this. I hope to find Vivelle again. I am looking for other options.”

3 / 10
popatya · Taken for 1 to 6 months July 22, 2013

Estradot 50 (estradiol) for Postmenopausal Symptoms: “I started this medication and within 2 weeks my life changed, just feel so good, feel like 13 again, no hot flashes, my appetite returned back, my hair texture feels good, it's all good, heaven sent, amazing, highly recommend, just worried about long term use.”

10 / 10
Hrm2 · Taken for less than 1 month August 23, 2019

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “Absolutely AWFUL!! I have been prescribed Estradiol Patches made by Sandoz and I am supposed to keep it on for a week. I maxed out at 6 1/2 HOURS ....they are truly worse than generic cartoon Band-Aids that are overpriced & don't stick! How in the world did these ever pass quality control from the FDA?!?! A total rip-off!! I clean with alcohol, let air dry, used tape and they still come off. ANY amount of perspiration will make them bubble right off. Sorry, but we all perspire EVERY SINGLE DAY! How was that little tidbit overlooked?”

1 / 10
Switching patches · Taken for 1 to 6 months June 6, 2020

Estradiol Patch (estradiol) for Oophorectomy: “I have been on the Mylan estradiol patch only since March 2020 and have patch-sized round burn like spots in every single place I’ve used this patch. The medication itself works fine for me but it hate the patch! It’s on the larger side and is thick and catches in clothing easily. If it gets wet at all it’ll peel right off. The material it’s made of holds moisture and halfway through the week it’s wet underneath no matter how long it has been since I’ve been in the water. I started putting tegaderm over it first thing but even still when I take it off it’s wet underneath and smells. It is unfortunately the only one my insurance will cover, however my dr is working in changing it to a combo patch. Hopefully insurance will approve it because I’m so tired of this one!”

4 / 10
SusyQ · Taken for 1 to 6 months May 15, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “This patch is so frustrating. It only stays on a couple of days because the material is it made of allows the water to soak in when you shower. Then the skin stays wet underneath and starts smelling sour. The adhesive on the edges irritate my skin and causes itching..What good is it if I can only get about 3 days out if it? I used to use a thinner patch made out of a different material and I never could tell I even had it on, but the company quit producing it.”

8 / 10
mommamia45 December 5, 2014

For Postmenopausal Symptoms: “A life saver! I was crying all the time, hot flashes, insomnia, night sweats. Everything blissfully went away pretty quickly after I started taking 0.5 dose in pill form. At first I noticed a bit of breast tenderness and headaches but after a week or two they were gone. My breasts have filled out a bit which is a bonus! My only regret is that I didn't start this 5 years ago instead of suffering through it. Wonderful stuff!”

9 / 10
Jay October 14, 2020

Climara (estradiol) for Postmenopausal Symptoms: “First of all I think I live in a lucky Country Australia and only pay $22 for 1 month supply and that’s without insurance. I found clear adhesive surgical patches and whack em over the top and it does the job. Mine stays on all week. I do find by day 5 and 6 it’s wearing off, I’m an emotional wreck. I’m on 50 so might have to change it by day 4 or get a higher dose. Only been on the patches 8 weeks and if I don’t get this dosage right I might end up doing time lol.. All I know is in my next life I want to come back as a man!”

6 / 10
CindiLou · Taken for 1 to 2 years August 19, 2020

Estradiol Patch (estradiol) for Postmenopausal Symptoms: “Sandoz Estradiol Patch does not stick. It does not peel, instead the entire patch comes loose at once. I get 2 days, maybe 3 days out of a patch. Do not accept Sandoz brand from your pharmacy, you will be wasting your money.”

1 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.