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Elestrin Pump

Generic name: estradiol topical (for use on skin)ess-tra-DYE-ol-TOP-ik-al ]
Drug class: Estrogens

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 25, 2023.

What is Elestrin?

Elestrin is estradiol 0.06% in a colorless, non-staining gel supplied in a non-aerosol, metered-dose pump container. Estradiol is a form of estrogen, a female sex hormone made in the ovaries that regulates many processes in the body.

Elestrin is used after menopause to reduce moderate to severe hot flashes.

Ovaries normally stop making estrogens when a woman is between 45 to 55 years old. This drop in body estrogen levels causes the “change of life” or menopause (the end of monthly menstrual periods). When estrogen levels begin dropping, some women develop very uncomfortable symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (“hot flashes”). In some women, the symptoms are mild, and they will not need estrogens. In other women, symptoms can be more severe and treatment with products such as Elestrin may help.


You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, bleeding problems, an increased risk of blood clots, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use Elestrin gel if you are pregnant.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using Elestrin can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia.

Estradiol topical is absorbed through the skin and can cause side effects in a child who comes into contact with the skin where you have applied Elestrin gel.

You should not use Elestrin if you have:

Estradiol will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estradiol may also increase your risk of uterine or ovarian cancer. Talk with your doctor about your individual risks.

To make sure Elestrin is safe for you, tell your doctor if you have:

Do not use Elestrin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine.

Estradiol can pass into breast milk and may harm a nursing baby. This medicine may also slow breast milk production. Do not use Elestrin if you are breastfeeding a baby.

How should I use Elestrin?

Use Elestrin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Elestrin comes with patient instructions for safe and effective use, and directions for priming the gel pump. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Children should avoid coming into contact with skin areas where you have applied Elestrin. Topical estradiol is absorbed through the skin and can cause premature puberty in a child who comes into contact with this medicine or with skin where the medicine was applied. Cover treated areas with clothing to protect others from coming into contact with the skin where you apply this medicine.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Store Elestrin at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, stomach pain, breast tenderness, drowsiness, and vaginal bleeding.

What should I avoid while using Elestrin?

Avoid getting Elestrin gel in your eyes. If this does happen, rinse with water.

Wait at least 25 minutes after applying Elestrin before you apply sunscreen to the same skin area.

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Elestrin side effects

Get emergency medical help if you have signs of an allergic reaction to Elestrin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Elestrin and call your doctor at once if you have:

Topical estradiol is absorbed through the skin of a child who comes into contact with this medicine. Call your doctor if a child who has close contact with you develops swollen nipples or enlarged breasts.

Common Elestrin side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Elestrin?

Other drugs may interact with estradiol topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Elestrin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.