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Femtrace

Generic name: estradiol oraless-tra-DYE-ole ]
Brand names: Estrace, Femtrace, Gynodiol
Drug class: Estrogens

Medically reviewed by Drugs.com. Last updated on Nov 8, 2024.

What is Femtrace?

Femtrace is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Femtrace is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Femtrace is sometimes used as part of cancer treatment in women and men.

Femtrace may also be used for other purposes not listed in this medication guide.

Warnings

Femtrace can harm an unborn baby or cause birth defects. Do not use Femtrace if you are pregnant. You should not take Femtrace if you have abnormal vaginal bleeding, liver disease, breast or uterine cancer, hormone-dependent cancer, a recent history of heart attack or stroke, if you are pregnant, if you have ever had a blood clot (especially in your lung or your lower body), or if you are allergic to any medicines or food dyes. Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have diabetes, high blood pressure, high cholesterol or triglycerides, if you smoke, or if you are overweight.

Long-term Femtrace treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using Femtrace long-term. Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.

Taking progestin while using Femtrace may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using Femtrace.

Femtrace should not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using Femtrace.

Before using Femtrace

You should not take Femtrace if you are allergic to estradiol, or if you have:

Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have risk factors such as diabetes, high blood pressure, high cholesterol or triglycerides, smoking, or being overweight.

To make sure you can safely take Femtrace, tell your doctor if you have any of these other conditions:

FDA pregnancy category X. Femtrace can harm an unborn baby or cause birth defects. Do not use Femtrace if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Femtrace can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. You should not breast-feed while you are taking Femtrace. Estradiol should not be used to prevent heart disease, stroke, or dementia, because Femtrace may actually increase your risk of developing these conditions.

How should I use Femtrace?

Take Femtrace exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Long-term Femtrace treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using Femtrace long-term.

Taking progestin while using Femtrace may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using Femtrace.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using Femtrace. Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.

If you need medical tests or surgery, or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are taking Femtrace.

Store Femtrace at room temperature away from moisture, heat, and light.

estradiol, Premarin, Estrace, conjugated estrogens

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause nausea, vomiting, or vaginal bleeding.

What should I avoid?

Do not smoke while using Femtrace. Smoking can increase your risk of blood clots, stroke, or heart attack caused by estradiol.

Femtrace side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Femtrace: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Femtrace and call your doctor at once if you have a serious side effect such as:

Less serious Femtrace side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Femtrace?

Tell your doctor about all other medicines you use, especially:

This list is not complete and other drugs may interact with Femtrace. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Does Femtrace interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.