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User Reviews for Premarin

Premarin has an average rating of 7.5 out of 10 from a total of 72 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 19% reported a negative effect.

Condition Avg. Rating Reviews Compare
Postmenopausal Symptoms  
7.4
34 reviews 157 medications
Oophorectomy  
8.7
12 reviews 35 medications
Atrophic Vaginitis  
4.3
9 reviews 54 medications
Primary Ovarian Failure  
8.0
5 reviews 36 medications
Abnormal Uterine Bleeding  
3.7
4 reviews 102 medications
Hypoestrogenism  
10.0
4 reviews 37 medications
Osteoporosis  
10.0
3 reviews 137 medications
Atrophic Urethritis  
10.0
1 reviews 46 medications
Summary of Premarin reviews 7.5 72 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Premarin

Starza October 30, 2020

For Postmenopausal Symptoms: “Premarin is a miracle for me. I'd been menopausal for 11 years, the last 2-3 of which I'd been suffering deep major clinical depression. The pandemic made it worse. My last menstrual period was more than 10 most ago. Still depressed, summer came, and the hot flashes started! And a bunch of difficult personal things happened that I really had to deal with and be present for, and finally I just had nothing left. I had no reserve, I had no buffer I got to the point where a broken pencil might send me to bed for the whole day. I hardly ate. I was living on a knife's edge emotionally. I nearly cracked. I couldn't handle it anymore. Premarin save my life! After just a week on the starter dose of .3mg, I felt like a new person/my old self. It is a miracle it's been about a month and I'm still feeling great on that low dose,; we're just going to stick with it for now. I am hoping it will bring my ability to orgasm back. That just went away one day, a few months ago...poof! Bummer...”

10 / 10
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Happy 123 · Taken for less than 1 month May 27, 2019

For Postmenopausal Symptoms: “At 50 years old and being peri menopausal I started feeling crazy, I was very angry, bitter, agitated everyday. I was never ever this way before this. My periods were longer than usual. Went to Dr. who found a fibroid. Went on premarin .625 which saved my life. I was thinking about not wanting to live anymore before starting on Premarin - so sad. After 1 month on premarin I am back to me!!!!!! Very happy and loving life.”

10 / 10
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Dink · Taken for less than 1 month February 8, 2020

For Postmenopausal Symptoms: “I was given premarin for hot flashes and vaginal irritation from vaginal dryness. It helped with my sex drive. I still have vaginal irritation and dryness from time to time. Now I'm wondering is I have a yeast infection because I have some burning. I've only been on it for one month. I suffer from depression and all this has caused me to lose weight, about 40lbs. My night sweats have improved but during the day they are bad. I don't know what is going on with this vaginal irritation. It's the worst. I'm 47. I'm irritated and moody and get annoyed quickly. My poor husband doesn't know what to do. I've changed my soap and detergents. I'm scared . My mind's Is all over and I forget things. That's not me at all. Any advise”

4 / 10
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West Coast · Taken for 1 to 6 months August 29, 2020

For Atrophic Vaginitis: “Premarin is a complete game changer. I had a 10cm mass on ovary and uterine hyperplasia. I thought things couldn't get any worse with pain and discomfort. This resulted in full hysterectomy and oophorectomy. Then, it went from bad to worse. Atrophy. Sex was so painful I gave up. Even urination was a challenge some days. This went on for a year. Then I started using Premarin. Within a week, things started to improve. I hesitated using Premarin because of some bad advice from the internet. Premarin is a complete game changer. I wish I would have tried it sooner. I have my sex life back and feel like my old self. Incredible!”

10 / 10
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Lucky to be here · Taken for less than 1 month June 22, 2016

For Postmenopausal Symptoms: “I was in the DEEPEST pit of depression. I felt that it was hormonal. Had labs drawn and was shown to be in menopause. Had a hysterectomy which left me with one ovary. The depression started this year in March and spiralled out of control. I was seriously deciding whether or not to stick around not because I didn't want to live, but the mental pain was too much. I noticed in a study of women that were treated successfully for severe hormonal depression using premarin and mirtazipine. Within 24 hours the depression was GONE GONE GONE! I believe it is mostly the premarin because ADs take longer than that to work. I want to start a campaign for the horses that are being treated to poorly. Why can't we get this from pg. humans and pay them?”

10 / 10
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devante9901 · Taken for 1 to 2 years January 14, 2015

For Postmenopausal Symptoms: “Hormone Replacement Therapy (HRT) - I took Prempro for two years after becoming menopausal at age 40. When it stopped working a year ago, I was changed to a daily combination of Premarin 1.25 and medroxyprogesterone 2.5. Without HRT I experience irritability and irrational rage, hot flashes, and a non-existent sex drive. The current HRT which includes Premarin, works very well for me. It is frustrating how difficult it is for a woman in her 40s to be taken seriously by the medical community for complaints of low libido. (Consider Viagra, etc. for men). Every year my doctors suggest I give up this medication therapy that increases my quality of life 100%. I'm 43 and so far I'm winning, but I expect that I will have to keep fighting.”

10 / 10
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Anonymous August 12, 2019

For Postmenopausal Symptoms: “Wake up America!!! This drug comes from the urine of pregnant mares hooked up to a catheter their entire life!!!! The horses have to have foals and what happens to them? Choose a synthetic form. Educate yourself. ”

1 / 10
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TIRA · Taken for 10 years or more July 30, 2020

For Postmenopausal Symptoms: “21 years old had two babies, endometriosis, was told I won't have anymore babies. Uterus was tilted and prolapsed. Didn't use birth control, due to ob-gyn said it would be a miracle to get pregnant. Got pregnant two more times, had a hysterectomy with last baby. I was put on many different hormones and none seemed to help my extreme moods, dry skin and wrinkles. Finally, I was told to try Premarin. It is very expensive, and insurance doesn't cover them, but it was like a dream come true. I became at peace, happy, and my skin became soft, wrinkles disappeared, and my sex life wasn't dormant anymore. I've got so many friends now using it, due to me telling them about my "happy pill", Premarin!”

10 / 10
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Bozzo123 May 6, 2010

For Postmenopausal Symptoms: “I had a hysterectomy in 1998. I had a horrible 2 years prior with night sweats, mood swings,(huge swings), irritability, then after my hysterectomy, I started taking Premarin 1.25. Have been on it ever since. For me, it is a life time therapy, that quite honestly I cannot be without. I forgot to take them once for 2 weeks, I went into such a rage, and cried, until I realized I had forgotten to get it filled. NEVER AGAIN. In my 50's my hot flashes no longer exist, my mood is even most of the time, and I enjoy the physical side of a relationship, more than I did when I was younger.”

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overlyworkedup October 13, 2017

For Postmenopausal Symptoms: “So I just started this yesterday and wonder I am feeling a little bit worked up (sexually charged) has anyone else experienced this? My main concern was dryness I had a hysterectomy, 11 years ago and was taking Estradiol and didn't really feel anything different would still get the hot flashes mostly during the day but BOY o BOY today definitely increased libido! Just looking to see if this is normal?”

10 / 10
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Dreamcatcher45 · Taken for 10 years or more September 9, 2016

For Postmenopausal Symptoms: “I took Premarin daily since 1975,with no problems, and felt great, young at heart and full of energy. Last year the insurance company decided they would not pay for it anymore and suggested Estradiol. I don't feel the same. No energy, hair thinning and bloated all the time. Next doctor appointment I'm going back on Premarin even tho it'll cost me a pretty penny.”

10 / 10
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Anonymous September 27, 2011

For Osteoporosis: “Have been on hormones for 25 years. Mom died at 59, Dad at 55. I am 79, still play active tennis = weight training- golf and do not have the usual aches and pains. If you do not have any serious illness get on the hormones.”

10 / 10
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lemonslice January 24, 2015

For Postmenopausal Symptoms: “I had a hysterectomy 9 years ago and have been suffering with hot flashes, tired, no energy and lots of other symptoms. Went to my doctor and he did not want to give me any HRT but I could not cope anymore with some of the hot flashes tiredness no energy and numerous other symptoms so decided to go back to my doctor and ask again for something to help me this time he has prescribed me Premarin. Its early days yet but already my hot flashes are starting to subside seems to be starting to help great to at last get a tablet to help I am very pleased with the Premarin and no side effects.”

10 / 10
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Anonymous July 5, 2011

For Postmenopausal Symptoms: “I had surgery in 1995 and the other half in 2004. I have been taking Premarin since then. I am now going through a divorce. Because of depression, I stopped taking my medicines. NEVER AGAIN. The past two months have been hell without my Premarin. Not sleeping because of night sweats, hot flashes all day and just feeling like I have no energy. I have started back for 6 days now and can already feel the difference. I will never stop taking Premarin again.”

10 / 10
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BorzoiDiva · Taken for less than 1 month September 25, 2018

For Postmenopausal Symptoms: “Doc prescribed it, but asked her to switch to Estrace and have good results. Y'all do realize that Premarine is a shortened version of Pregnant Mare Urine which is what it's made from? They take large (most commonly Belgium Draft Horses) and confine them in small stalls for their 11-month gestation with their tails tied up and catheters on to harvest their urine. Female foals are cycled back into the program. Males are useless so sold off to auction houses, some are lucky to get purchased by rescues, others are sold to end up as horsemeat in other countries. The mares are bred again once they've foaled to continue the cycle. Ironic that a drug developed to help post productive human females is derived from horrific treatment of female horses during their productive years. It is an awful life. Please find an alternative.”

1 / 10
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Maggie568 July 7, 2013

For Hypoestrogenism: “I had a hysterectomy in 1980 and have been on Premerin 1.25 mg for 33 yrs and have no problems at all. I love my Premarin. I hope I can keep getting Premarin because there have been times Drs. give you hard time and I need to keep taking it. I have terrible withdrawals. So I need it. I get awful headaches and pain. ”

10 / 10
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southernutahlady October 14, 2010

For Hypoestrogenism: “I have taken .9 Premarin (natural estrogen) for 23 years (after my uterus was removed at 34 and symptoms developed), and I am just fine (unless I don't take it). Any attempt to use any oral artificial estrogen made me very sick and the patches left red welts that lasted for months. So I have stayed with oral Premarin, and although I don't appreciate the way horses are treated in order to produce it, I am very grateful that it stops the severe sweating, hot flashes, shakiness and weakness that comes if I miss it for a day or two. It did not prevent osteoporosis. I do look 15 years younger than I should - possible good side effect. 23 years and no problems.”

10 / 10
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Jah1016 April 5, 2021

For Postmenopausal Symptoms: “Best for me. Tried all of HRTs, estrace pills, patches, pellets, injections and premarin works best tho not cheap. Premarin pills 1.25mg 2/day plus Premarin cream 1 gram daily plus low dose progesterone (2.5mg) the only solution for me. Had endometrial ablation years ago and don't need progest but found tiny dose helps the prem work better. If you have trouble means either the dose, brand or delivery is not correct for your chemistry. The progesterone most MDs rx is Prometrium 100mg, only during pregnancy does a woman's body ever make that high a level! Pre-meno non preg women only produce ~25-30mg progesterone daily and ~1.5-9.0 mg estrogen daily. Progesterone can convert into estrogen which can help meno symptoms but it doesn't convert in all women the same. Prometrium was much too high for me (gave me bad symptoms) I needed less progesterone and higher estrogen to feel balanced. Watch youtube videos of Menopause Taylor (Dr. Barbara Taylor) she explains everything.”

10 / 10
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Fbuds March 12, 2018

For Primary Ovarian Failure: “Had a hysterectomy at age 35 with ovaries left in tact. Night sweats appeared gradually and by age 53 were intolerable. I was awake most of night and kept my husband up as well. Was prescribed Premarin at the lowest dose. I experienced relief after 2 days. I can’t believe how much better I feel. Now 2 weeks in my brain fog is gone and I am so happy. I didn’t realize how depressed I was. No side affects at all. Just look forward to peaceful sleeps at night”

10 / 10
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curleysue September 19, 2009

For Postmenopausal Symptoms: “I had a hysterectomy in 1998 and was on Premarin 0.0625 for many years then Doctor decided not good to prescribe anymore. I was so very miserable! If have to live like that -don't want to. It was terrible. No doctor knows your body like you do! And just for the record, one of my sisters is 73 yrs old aznd still has terrible hot flashes! Sometimes it looks as if she just stepped out of the shower! My mother was the same way! I am not willing to live like that! There are pro's and con's on everything!”

10 / 10
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anniemack August 24, 2016

For Postmenopausal Symptoms: “I have taken Premarin in the 1.25 strength for over 40 years, it has not stopped the hot flashes and night sweats but it reduces them by at least 50%. I do not have osteoporosis (my Mother and all of my Aunts did) and my bone density is better than most women half my age, a lot of which I attribute to the Premarin. I have never taken prempro or any progestin product, just the Premarin alone. I tried the half strength, miserable with all day hot flashes so over heated looked like I had a sunburn with heat rash and nasty skin breakouts, so I changed Drs, now back to the 1.25 strength. . My only complaint is that a product like this that ha been on the market over 50 years I do not understand why there is no generic as it is very expensive.”

8 / 10
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blonddraider · Taken for 5 to 10 years February 21, 2014

For Postmenopausal Symptoms: “Complete Hysterectomy: I was on Premarin started about 6 weeks after hysterectomy because I couldn't handle the restless leg syndrome and having to move all the time. I was put on 0.625 mg was on it from 2007 until 8 months ago. 5 weeks after doc took me off, my whole body and life went to double hockey sticks!! Anxiety, Severe! OCD crazy uncontrollable, and panic disorder through the roof. I am on Celexa 20mg daily and 1.75 mg broken into 6 doses. It works, but I don't understand it just doesn't work the same, I never had such bad OCD, anxiety, or panic like this while on and I want it back! I am gonna go get mamo if it comes back clean I'm going back on premarin! Will my life go back to normal? Will I feel like me again, and want to enjoy life? I have two appointments”

10 / 10
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kuli · Taken for 1 to 6 months November 19, 2014

For Atrophic Vaginitis: “I went on the medicine at age 65 due to extreme dryness and constant yeast infections. The fantastic side effect is now I fall to sleep within one hour of going to bed. For six years, ever since menopause, I have had trouble falling asleep (averaging only 4 hrs of rest). The only change in my life was the Premarin pill. It helped the dryness and now I can function with 8 hours of sleep!”

10 / 10
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Mag57 · Taken for 1 to 6 months May 24, 2017

For Postmenopausal Symptoms: “I am 57yrs. My sister in law mentioned that she took Premarin for 5 years with no side effects. I was intrigue, I never heard of this medication. I went to my doctor and asked for Premarin, she prescribed me 0.3mg. Wow, amazing results! No side effects. I just finished my 30 days’ supply, went back to my doctor; asked for a little higher dosage because I was still having hot flashes & vaginal dryness, so she prescribed another 30 days on 0.45. Of course, my doctor does not recommend this medication because all the possible side effects specially heart attack: I told her let me try and see how I feel. Now I will have one more month at .45mg, I will see what are the results. I will keep everyone posted.”

9 / 10
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BossLady March 31, 2020

For Postmenopausal Symptoms: “My third month using Premarin 0.625g due to unbearable hot flashes, vaginal dryness, sleep disturbances and night sweats. I had done hysterectomy about a year ago. Since taking Premarin, both hot flashes and night sweats lessened. Now my biggest challenge is persistent and enlarging painful breasts. Am due to discuss this feedback with my gynecologist.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.