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Premarin and Night Sweats: What Users Say

Night sweats: mentioned by 7 users (8.3%)

Based on user experiences from 84 Premarin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 21.4%
hair loss 8.3%
night sweats 8.3%
headaches 6.0%
mood swings 6.0%
bloating 4.8%
dizziness 4.8%
pain 4.8%
anxiety 3.6%
depression 3.6%

Reviews for Premarin

Commonly mentioned side effects
  • Din...
  • Taken for less than 1 month
  • February 8, 2020

For Postmenopausal Symptoms "I was given Premarin for hot flashes and vaginal irritation from vaginal dryness. It helped with my sex drive. I still have vaginal irritation and dryness from time to time. Now I'm wondering if I have a yeast infection because I have some burning. I've only been on it for one month. I suffer from depression and all this has caused me to lose weight, about 40 lbs. My night sweats have improved but during the day they are bad. I don't know what is going on with this vaginal irritation. It's the worst. I'm 47. I'm irritated and moody and get annoyed quickly. My poor husband doesn't know what to do. I've changed my soap and detergents. I'm scared. My mind is all over and I forget things. That's not me at all. Any advice."

4 / 10
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  • Anonymous
  • July 5, 2011

For Postmenopausal Symptoms "I had surgery in 1995 and the other half in 2004. I have been taking Premarin since then. I am now going through a divorce. Because of depression, I stopped taking my medicines. NEVER AGAIN. The past two months have been hell without my Premarin. Not sleeping because of night sweats, hot flashes all day and just feeling like I have no energy. I have started back for 6 days now and can already feel the difference. I will never stop taking Premarin again."

10 / 10
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144 Report
  • Boz...
  • May 6, 2010

For Postmenopausal Symptoms "I had a hysterectomy in 1998. I had a horrible 2 years prior with night sweats, mood swings (huge swings), irritability. Then after my hysterectomy, I started taking Premarin 1.25. I have been on it ever since. For me, it is a lifetime therapy that, quite honestly, I cannot be without. I forgot to take them once for 2 weeks. I went into such a rage and cried until I realized I had forgotten to get it filled. NEVER AGAIN. In my 50s, my hot flashes no longer exist, my mood is even most of the time, and I enjoy the physical side of a relationship more than I did when I was younger."

9 / 10
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152 Report

Frequently asked questions

  • ann...
  • August 24, 2016

For Postmenopausal Symptoms "I have taken Premarin in the 1.25 strength for over 40 years. It has not stopped the hot flashes and night sweats, but it reduces them by at least 50%. I do not have osteoporosis (my mother and all of my aunts did) and my bone density is better than most women half my age, a lot of which I attribute to the Premarin. I have never taken Prempro or any progestin product, just the Premarin alone. I tried the half strength and was miserable with all-day hot flashes, so overheated that I looked like I had a sunburn with heat rash and nasty skin breakouts. I changed doctors and now back to the 1.25 strength. My only complaint is that a product like this, which has been on the market for over 50 years, I do not understand why there is no generic as it is very expensive."

8 / 10
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80 Report
  • Bos...
  • March 31, 2020

For Postmenopausal Symptoms "My third month using Premarin 0.625 g due to unbearable hot flashes, vaginal dryness, sleep disturbances, and night sweats. I had a hysterectomy about a year ago. Since taking Premarin, both hot flashes and night sweats have lessened. Now my biggest challenge is persistent and enlarging painful breasts. Am due to discuss this feedback with my gynecologist."

8 / 10
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23 Report

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  • Dan...
  • Taken for 1 to 6 months
  • February 22, 2022

For Postmenopausal Symptoms "I suffered from horrible night sweats, flashes all day long, and a mean foul temper due to lack of restful sleep and lack of estrogen, apparently. Had a partial hysterectomy at 44, started HRT at 50. Finally found a doctor who didn't just give me a pat on the arm and an antidepressant. Started with Premarin and found myself. Sleep was restful, I could tolerate people and even enjoy them, my husband no longer was at risk of being the target of tears, anger, resentment, sadness, and happiness all in the matter of minutes... then my insurance said it was no longer covered. Tried a few other 'covered' options and have been MISERABLE! The flashes and night sweats are even worse. Wishing there was a synthetic form of this, hoping for a generic that works BUT have not been successful, seriously trying to figure out how to make $500 a month to be able to stay on it and have quality of life."

10 / 10
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  • san...
  • Taken for less than 1 month
  • July 25, 2012

For Postmenopausal Symptoms "I have just started taking Premarin and I must say, the night sweats are gone along with the irritability. I have so much more energy than I know what to do with and my libido is back!"

10 / 10
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153 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.