Premarin and Depression: What Users Say

• hap...
• August 28, 2011

For Oophorectomy "Had oophorectomy 8 years ago. On the second week, I started to have terrible hot flashes, couldn't sleep anymore. The doctor started me on all you can name before trying Premarin. Since taking Premarin, I got my life back. Several times, the doctor tried to decrease the dose and wean it off completely. I went into deep depression, crying all the time, and back to the nightmare again. Thanks to Premarin, I feel like a normal human being again. As a floor nurse on a cardiac floor, I have talked to several ladies in their seventies still taking Premarin daily. My actual dose for years has been 0.65 mg daily."

• Jam...
• Taken for 10 years or more
• January 12, 2025

For Oophorectomy "I began menstruating at age 14, suffered severe PMS 2 weeks per month, and had severe pain for several days during each period. Age 30, miserable most days, uterus and ovaries removed. Given Premarin & told to never go off. PMS and pain gone forever! Dose gradually reduced & I’m doing fine. 80, taking the lowest dose, .3 mg. Through the years, I tried to go off of Premarin several times & suffered severe hot flashes, fatigue, PMS, and depression. Without Premarin, I do not have a life worth living because I’m sick almost every day & can’t function. I know taking Premarin may cause cancer. Tell your doctor to please give you good information about the cancer risks and a choice to keep taking it or not. I choose to not be sick all of the time vs. the tiny chance of cancer. In my opinion, physicians who refuse to prescribe Premarin under certain circumstances are not listening or don’t care enough. I’ll always choose a physician who can hear & help me."

• Kit...
• Taken for 10 years or more
• October 26, 2019

For Oophorectomy "Now 73. Partial hysterectomy at 27, symptoms of menopause and thyroid failure at 35, extreme depression and suicidal at 43. Doctor tested estrogen, and it was almost nonexistent. I was on the .625 Premarin dosage for about 15 years (thyroid medication was prescribed during that time also) and then switched to .3 with no problems. I read that it is not usually prescribed after 70 and asked my doctor what to do, afraid of the symptoms coming back. She said many older patients reduce their medication, so at 70, I cut back to 3 tablets of .3 a week and am happy to report that I have had no problems. My EHB covers 80% of the cost. This pill saved my life!"