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Premarin and Pain: What Users Say

Pain: mentioned by 4 users (4.8%)

Based on user experiences from 84 Premarin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 21.4%
hair loss 8.3%
night sweats 8.3%
headaches 6.0%
mood swings 6.0%
bloating 4.8%
dizziness 4.8%
pain 4.8%
anxiety 3.6%
depression 3.6%

Reviews for Premarin

Showing 4 reviews tagged with "pain". Clear filters to view all 84 reviews.
Commonly mentioned side effects
  • Wes...
  • Taken for 1 to 6 months
  • August 29, 2020

For Atrophic Vaginitis "Premarin is a complete game changer. I had a 10 cm mass on my ovary and uterine hyperplasia. I thought things couldn't get any worse with pain and discomfort. This resulted in a full hysterectomy and oophorectomy. Then, it went from bad to worse. Atrophy. Sex was so painful I gave up. Even urination was a challenge some days. This went on for a year. Then I started using Premarin. Within a week, things started to improve. I hesitated to use Premarin because of some bad advice from the internet. Premarin is a complete game changer. I wish I would have tried it sooner. I have my sex life back and feel like my old self. Incredible!"

10 / 10
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  • Mag...
  • July 7, 2013

For Hypoestrogenism "I had a hysterectomy in 1980 and have been on Premarin 1.25 mg for 33 years and have no problems at all. I love my Premarin. I hope I can keep getting Premarin because there have been times doctors give you a hard time and I need to keep taking it. I have terrible withdrawals. So I need it. I get awful headaches and pain."

10 / 10
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  • Jam...
  • Taken for 10 years or more
  • January 12, 2025

For Oophorectomy "I began menstruating at age 14, suffered severe PMS 2 weeks per month, and had severe pain for several days during each period. Age 30, miserable most days, uterus and ovaries removed. Given Premarin & told to never go off. PMS and pain gone forever! Dose gradually reduced & I’m doing fine. 80, taking the lowest dose, .3 mg. Through the years, I tried to go off of Premarin several times & suffered severe hot flashes, fatigue, PMS, and depression. Without Premarin, I do not have a life worth living because I’m sick almost every day & can’t function. I know taking Premarin may cause cancer. Tell your doctor to please give you good information about the cancer risks and a choice to keep taking it or not. I choose to not be sick all of the time vs. the tiny chance of cancer. In my opinion, physicians who refuse to prescribe Premarin under certain circumstances are not listening or don’t care enough. I’ll always choose a physician who can hear & help me."

10 / 10
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Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • August 29, 2017

For Atrophic Vaginitis "Feeling great for 4 months. Pain returning the last 3 days."

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.