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User Reviews for Estrace Vaginal Cream

Condition Avg. Rating Reviews Compare
Atrophic Vaginitis  
6.5
61 reviews 54 medications
Atrophic Urethritis  
5.0
10 reviews 46 medications

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Estrace Vaginal Cream

Lulu · Taken for 1 to 6 months April 15, 2021

For Atrophic Vaginitis: “I'm 54 years old and a couple years into menopause. I started taking this because intercourse was starting to really hurt. A couple weeks in sex was comfortable and fun again. But about 6-7 weeks after starting it, I became depressed. I don't know if it's related. I've been gritting my teeth trying to power through the depressive feelings for 3 weeks now, but it's getting a lot worse. I just put a call into my doc, and I think I'll stop using it. Very sad for me, because it worked very well for its prescribed purpose.”

7 / 10
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Dc March 22, 2021

For Atrophic Vaginitis: “I felt like I had a UTI for several months and was losing sleep due to the sensation of needing to urinate constantly. There were also lots of BV and yeast infections so it was frustrating. I found an official OBGYN who was a God send. I’m replying early on with this medicine because after a few days all of the old symptoms were gone. Into it a bit over a week and feel normal again. When I started it I think I was so dried out that my skin could not even absorb this internally as I’d see it the next morning (I assume it was the cream), but even with that - it has helped and I hope they don’t stop prescribing. Quality of life and comfort is important for mood stabilization etc. No point in living to be 100 if it’s painful everyday. Love this cream.”

10 / 10
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Cece · Taken for 1 to 6 months January 23, 2021

For Atrophic Vaginitis: “My doctor prescribed a low dosage of Estrace Cream twice a week for frequent UTI's. Right off I got severe itching but gave it time to go away then got breast tenderness and pelvic pain. Been on it for almost 3 months haven't had a UTI however what side effects I have not to mention the cost. Going to quit Using it I will figure a way to control the UTI's. Not worth dealing the side effects.”

5 / 10
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Frequently asked questions

Ellie · Taken for 2 to 5 years September 21, 2020

For Atrophic Vaginitis: “Horrible itching, burning, swelling from any topical estrogen I tried - estrace, vagifem, premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - versabase is hypoallergenic. I AM CURED - the compounded estriol in versabase has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!”

1 / 10
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Jlady May 28, 2013

For Atrophic Vaginitis: “I'm 71 years old. The tearing and associated pain started a few months ago. Just hoped it would go away but it did not. I would not let my husband touch me. Spoke with 2 doctors I know and they said its normal but Estrace would help. It did. My prescription is dated 3/7/2013. Within 10 days the tearing stopped and all was healed. Use 1 gram 3 X a week. Nothing bad has happened. My libido near immediately was through the roof. I am amazed and nobody needs to try and take this medicine away from me! I'm loving it and my husband is happy too. Yes, my age up there is right.”

10 / 10
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letmepost654 · Taken for 5 to 10 years July 16, 2013

For Atrophic Vaginitis: “I'm 65 and had ovaries removed 11 years ago, along with uterus and cervix. Since that, I have almost no sex drive and intercourse was super painful. Estrace vaginal cream really helps, and I only have to use a pea sized dab every other day. Just using a finger to apply at bedtime works great. It seems to me that the dire warnings about using estrogens is misleading since no studies have been done on just vaginal estradiol rather than on oral estrogen, and much higher doses are still prescribed than are needed for maintenance. Without Estrace vaginal cream, intercourse would be impossible and husband would be very unhappy. ”

10 / 10
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twistedK · Taken for less than 1 month January 23, 2016

For Atrophic Vaginitis: “So - I was prescribed this and was shocked when I went to the pharmacy and she said $135. Dr. never mentioned this. I said "doesn't my insurance pay anything on this?" She checked and said "It's normally $350.00" or something. I was really angry. Angry, embarassed and this whole experience is humiliating to women. Why do I think a prescription of Viagra has a co-pay of like $10?? IT'S TIME TO STOP DISCRIMINATING AGAINST WOMEN. Especially us older women!!! That is ridiculous!!! I did not buy it, I was so angry. I may.... but I doubt it. I was prescribed this with an oral progesterone -- any one have experience with these two items combined? Thanks for letting me air that - take heed, Big Pharma.”

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More FAQ

Sara55 · Taken for less than 1 month December 30, 2019

For Atrophic Vaginitis: “I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also Allergen offered free applicators but Mylan won’t even answer an e- mail regarding this. I think it VERY unsanitary to expect one to reuse the tubes. Allergen won’t even respond when I asked if I could buy the applicators for the generic- I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand??”

8 / 10
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Gram · Taken for 1 to 6 months June 6, 2019

For Atrophic Vaginitis: “I am 71 years old and my doctor prescribed estradiol for vaginal atrophy. I was reluctant to try it but my symptoms worsened so I started the estradiol 3 times a week. After a few weeks I was symptom-free and feeling great. However after 3 months my symptoms gradually returned and now I have burning all day and the urination urgency off and on during the day. My symptoms abate at night. My doctor doesn’t have any answers as to why the medication stopped working. Does anyone else have this problem and what was your solution.?”

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Sexpert March 30, 2016

For Atrophic Vaginitis: “Very sexually active until severe abrupt menopausal symptoms at 55. AV symptoms the most bothersome as overnight I shrunk up, dried up, itched, burned and tore. Intercourse was out of the question. Dr. gave me a sample of Estrace Vaginal cream. I admit I was afraid to use it and had little faith that it would help so I used only a pearl size amount on clean dry skin every night for 2 weeks. That ammt. Is sufficient to cover all the external parts and more, it emulsifies. I am COMPLETELY healed as far as pain with intercourse and also pain upon urination. It was a MIRACLE for me. Side note: If you stop using it (3X a week after the initial 2wk nightly use) you'll be back at square 1. I give Estrace a 10+ rating C: A tube lasted 6 months”

10 / 10
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CeeGal · Taken for 1 to 6 months December 16, 2016

For Atrophic Vaginitis: “I've been married for 35 years. After menopause, intercourse became impossible due to dryness and pain. I do not go to the doctor as often as I should, so I suffered for years, and tried to find "natural remedies" on my own to no avail. I finally gave in and went to a gynecologist. I was embarrassed to even tell him, but I knew I had to do something. He was familiar with the problem and put me on Estrace cream. Within days, I was a NEW person. Saved my life and my marriage. Excellent results and fast!”

10 / 10
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denah November 18, 2013

For Atrophic Vaginitis: “I am 50 yrs old and post menopausal - basically in full menopause.. I was prescribed this cream for thinning of the vaginal wall. I had increased urinary tract infections. I believe it helps with my libido which had dropped to zero! I hope this review helps. I didn't have dryness or pain with intercourse. My urologist prescribed it for me. It is really great to have doctors who "KNOW" what we are going through as females.”

10 / 10
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Leyaleo · Taken for 1 to 6 months September 3, 2014

For Atrophic Vaginitis: “Just posting an update from my last post a few months ago. The hypoallergenic estradiol (basically, a compounded version of Estrace from a compounding pharmacy) continues to be very effective for me - relieving vaginal burning/pain and urinary urgency/frequency. For women out there suffering those issues in perimenopause (when it hit me), know that it was suggested that I had interstitial cystitis and that I was off-base when I told doctors I was reacting badly to propylene glycol and glycerin, ingredients in many vaginal products. The compounded version of Estrace has been SO helpful for me and after many painful, difficult months, I feel myself again. ”

9 / 10
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Anon · Taken for 2 to 5 years June 19, 2018

For Atrophic Vaginitis: “For those who commented about burning from using Estrace...I also had burning from it. My research led me to believe that the propylene glycol and/or glycerin in the product were the culprits. I switched to a hypoallergenic form of estradiol from a good compounding pharmacy and that solved the problem. No burning and the estradiol was so helpful.”

9 / 10
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InPain · Taken for less than 1 month September 28, 2019

For Atrophic Vaginitis: “I am 53 and had a complete hysterectomy 27 years ago and have been taking oral Premarin. Dr. Put me on the Estradiol patch which gave me headaches so we just stopped all HRT. Few weeks later I developed a UTI and had extreme vaginal and urethra pain. Was put on Estradiol Cream which irritated all of my skin, so they switched me to Estradiol vaginal tablets. I have been using it for 10 days and I am burning, aching and it feels like something is stuck in me. I do not like this cream and am wondering if the Premarin cream would work better. I keep wondering if this pain will ever go way. Has anyone had symptoms for over 10 days while using the cream?”

1 / 10
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His Wife is back!!! November 15, 2015

For Atrophic Vaginitis: “I was experiencing very painful intercourse with tearing. I have used this medication exactly 3 times it has improved sex 99% already. Some pain on insurtion, but none during intercourse for the first time in years! I have no doubt it will get better as my body's estrogen levels improve.. So thankful. I am 55 yrs old.”

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debzaranti December 15, 2008

For Atrophic Vaginitis: “I'm a 56 year old postmenopausal woman. I've been postmenopausal for 4 years and have been using Estrace for the last 2 years. I use a minimal amount (2mg once a week). This has greatly helped with my vaginal dryness, as well as keeping the hot flashes in check (a surprising, yet unexpected side benefit). I have had no bad side effects I am aware of. Prior to using Estrace I was taking 2 or 3 oral hormones (with some side-effects), plus I was paranoid about the cancer risk with those. I discontinued the oral hormones and tried using NO hormones for about 6 weeks and couldn't stand it, so my doctor prescribed Estrace.”

9 / 10
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menopausal lady August 10, 2018

For Atrophic Vaginitis: “This cream has been a miracle. I had a hysterectomy 20 years ago and have been off estrogens for at least 15 years. About five years ago started having all kinds of vaginal discomfort. I think I was also battling a bacterial infection. Tried everything for that too. Finally settled on using boric acid capsules once a week for quite some time and the estrace three times a week. I used about 1gram. After several months finally I was able to stop the boric acid. I also was able to cut my estrace back to once a week 1gram. Before using this I was so sensitive that I would be burning and itching just from wiping with toilet paper. The tissue was so thin it looked shrivelled up down there. I noticed I had what appeared to be blood blisters on my labia which have gone away. The skin has plumped up too and is so much healthier. I would give this a ten except the cost is ridiculous.”

9 / 10
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Tennessee gal · Taken for less than 1 month May 15, 2014

For Atrophic Vaginitis: “I'm 48 years old, and my Doctor has recently prescribed me Estrace Vaginal Creme because intercourse was becoming unbearable. Very painful and I was tearing! Geez! So far, the vaginal pain and dryness seems to be decreasing, as I've been only using the creme for the past month. I have no side effects at all so far. That's a good thing! However, I do find the creme very expensive!”

9 / 10
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Leyaleo · Taken for 1 to 6 months June 9, 2014

For Atrophic Vaginitis: “At 46, I began having UTI's, urinary frequency/urgency, and burning vaginal dryness. I was prescribed Estrace, but the standard formula caused me burning as well. However, a compounded version of estradiol in a hypoallergenic formula has been very helpful. My vaginal burning has stopped, and the urinary urgency/frequency has improved dramatically over the last 2+ months. I think Estrace can be very helpful, and if you're sensitive to it (the propylene glycol can be an irritant), a compounded version can be extremely helpful.”

8 / 10
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Anonymous October 20, 2017

For Atrophic Vaginitis: “Help! Can anybody who has had burning after using this horrible creme tell me how long does the burning last? Anyway how do you stop the burning? I put it in once and have been burning for 24 hours... any way to stop the burn??”

1 / 10
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bgkaufman · Taken for 5 to 10 years February 29, 2020

For Atrophic Vaginitis: “The last 2 times when I used Estrace cream, I had bad burning and felt like I had a UTI. Out of desperation, I decided to try a vaginal yeast infection cream w/applicator to see if it made a difference. It did, both times!! Within hours, the symptoms decreased. By the next day, no further issues. Had no idea others had burning from the Estrace cream until I got on this site. May check out getting it compounded. I wonder why after years of using the Estrace (brand name), did this start all of the sudden. Have the ingredients changed??”

1 / 10
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CocopNP January 21, 2018

For Atrophic Vaginitis: “I am a health care provider in women's health and I prescribe this like crazy. Vaginal atrophy is no joke. Some people are allergic to whatever else that is in the cream, but for the most part is well-tolerated. It is estradiol, which is identical to the estrogen in your body ”

10 / 10
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Mialo February 14, 2017

For Atrophic Vaginitis: “The patches stopped working so this was last on the list to try. Dr. gave me a sample to try. Not very effective and Way Way overpriced. Will be trying compounded version. Wake up drug companies there are a lot of us baby boomers suffering from menopause who will not go quietly into the night. Especially when we're expected to keep working until 66.”

1 / 10
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India Anne June 1, 2015

“I had one area inside my labia that bothered me after sex. The dr said he thought it was Lichen. He gave me a sample of Estrace cream. I only massaged a small amount in the affected area. It took a few days for the discomfort to fade. After a week I noticed that my labia was tighter, not so flabby. My libido increased too. I wish I could bathe in this! It's a "facelift" for your vagina.”

10 / 10
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Sebastian · Taken for 2 to 5 years August 12, 2020

For Atrophic Vaginitis: “It's just okay with decreasing dryness, I still need to use other over the counter lubricants, but, this cream has brought back my sex drive! It stimulates my girl libido big time! So for that, I love this product!”

8 / 10
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Anonymous October 30, 2009

For Atrophic Vaginitis: “I'm 58 and recently started on this medicine. Almost immediate relief of vulvar dryness and pain. Not sure yet if the painful intercourse will be relieved but this looks optimistic to me after many months of intense pain. Medicine does not seem gooey or even noticeable when used. Really like it so far.”

9 / 10
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Tfruity · Taken for less than 1 month August 6, 2017

For Atrophic Vaginitis: “Painful sex for year and a half. Was at my wits end, finally went to the doctor and described severe pain and dryness not relieved. She prescribed this cream. Miracle drug! No more pain, dryness improving. My husband and I are thrilled! Go on their website for a coupon. Almost 300 bucks but I only had to pay $25.00”

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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.