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Estrace Vaginal Cream and Pain: What Users Say

Pain: mentioned by 6 users (7.3%)

Based on user experiences from 82 Estrace Vaginal Cream reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 22.0%
itching 8.5%
dryness 7.3%
pain 7.3%
bleeding 4.9%
headaches 4.9%
sexual dysfunction 4.9%
swelling 4.9%
hot flashes 3.7%
sore breasts 3.7%

Reviews for Estrace Vaginal Cream

Commonly mentioned side effects
  • His...
  • November 15, 2015

For Atrophic Vaginitis "I was experiencing very painful intercourse with tearing. I have used this medication exactly 3 times. It has improved sex 99% already. Some pain on insertion, but none during intercourse for the first time in years! I have no doubt it will get better as my body's estrogen levels improve. So thankful. I am 55 years old."

9 / 10
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142 Report
  • Anonymous
  • July 14, 2009

For Atrophic Vaginitis "I'm a 41-year-old woman who went into early menopause two years ago. Vaginal dryness and all the other wonderful symptoms of menopause are not something that I would like to deal with at my age, but sometimes we can't control. So, my doctor prescribed Estrace, and I use 1mg 2x a week. I was told that it would take about 6-8 weeks before seeing a difference. At the end of that time frame, I saw only a slight difference in vaginal dryness but many side effects. I had headaches, dizziness, bloating, and calf pain."

1 / 10
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119 Report
  • Pat...
  • October 25, 2016

For Atrophic Vaginitis "This past February, I literally thought my insides were being ripped out. I expected to see them lying on the floor after sex one Monday afternoon. I was throbbing and hurting the rest of the evening and into the morning. The next day, I called my GYN and begged to be seen. She diagnosed me with this and several rips. She gave me an Estrace cream sample and a prescription along with one for the rips. I do not have medical insurance. I healed the rips with coconut oil and started the cream, 1 oz, 2 times a week. She says it is not absorbed. Well, all I know is that my hot flashes have lessened, sex is not painful, and if I don't use it like I'm supposed to, all that changes! I'm blessed to have friends in the medical field that can keep me supplied with samples."

9 / 10
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56 Report

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Frequently asked questions

  • You...
  • Taken for 1 to 6 months
  • November 30, 2016

For Atrophic Vaginitis "I have suffered with endometriosis since I was 16 years of age. Needless to say, they did a full hysterectomy at 34 years of age, and I still suffered painful sex after having my hormone shots each month. I was still having pain. My doctor prescribed this cream, and so far, so good. Hopefully, it continues to help me. This is embarrassing to women, especially at this age."

7 / 10
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47 Report
  • Cec...
  • Taken for 1 to 6 months
  • January 23, 2021

For Atrophic Vaginitis "My doctor prescribed a low dosage of Estrace Cream twice a week for frequent UTIs. Right off, I got severe itching but gave it time to go away, then got breast tenderness and pelvic pain. Been on it for almost 3 months. I haven't had a UTI, however, what side effects I have-not to mention the cost. Going to quit using it. I will figure a way to control the UTIs. Not worth dealing with the side effects."

5 / 10
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14 Report
  • Anonymous
  • March 11, 2010

For Atrophic Vaginitis "I am 59, and it got to the point that I was avoiding sex. I had pain with intercourse and had to use lubricant all the time. I use 4mg once a week and am enjoying sex for the first time in years."

10 / 10
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165 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.