Estrace Vaginal Cream and Sexual Dysfunction: What Users Say

• Ell...
• Taken for 2 to 5 years
• September 21, 2020

For Atrophic Vaginitis "Horrible itching, burning, swelling from any topical estrogen I tried - Estrace, Vagifem, Premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - VERSABASE is hypoallergenic. I AM CURED - the compounded Estriol in VERSABASE has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use Estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!"

• Sar...
• Taken for less than 1 month
• December 30, 2019

For Atrophic Vaginitis "I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also, Allergan offered free applicators but Mylan won’t even answer an email regarding this. I think it's very unsanitary to expect one to reuse the tubes. Allergan won’t even respond when I asked if I could buy the applicators for the generic. I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand?"

• tar...
• February 10, 2016

For Atrophic Urethritis "My urologist has just put me on the cream 3 times a week for preventing UTIs. I just started using it, so not sure if it will help with this, but I pray that it does because the past year I have had one UTI after another, and I am tired of being on antibiotics all the time. The antibiotics are so hard on my gut. Anyways, no libido, and hopefully, that will improve too. So far, no bad side effects either, so that's good. I will be 60 in May. I always was very active sexually, now I don't even want to be touched, and my husband is not happy but understanding. So anyways, will report back, and hopefully this cream is a miracle worker!"

• Anonymous
• Taken for 2 to 5 years
• April 19, 2023

For Atrophic Vaginitis "I have been using the generic brand Estrace, 1g twice a week for three and a half years to alleviate the symptoms of vaginal atrophy caused by menopause, including dryness, burning, and itching. Initially, sex was comfortable until my husband's low testosterone and low libido issues caused a significant decrease in our sexual activity. As a result, my vagina has narrowed and shortened due to lack of use, causing painful intercourse, despite continuing the use of Estrace. I plan to increase my Estrace dosage for a few weeks to address these changes and improve the discomfort during sex. It is ironic that my husband's low libido has led to my discomfort, which now irritates him. Technically, it is his fault that we did not engage in sexual activity regularly, leading to these issues."