Estrace Vaginal Cream and Dryness: What Users Say

• Ell...
• Taken for 2 to 5 years
• September 21, 2020

For Atrophic Vaginitis "Horrible itching, burning, swelling from any topical estrogen I tried - Estrace, Vagifem, Premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - VERSABASE is hypoallergenic. I AM CURED - the compounded Estriol in VERSABASE has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use Estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!"

• Not...
• October 7, 2015

For Atrophic Vaginitis "I have been using 1 mg every night for 12 days and am not sure if I can tolerate my side effect symptoms much longer to see if the cream actually works to diminish extremely painful intercourse due to dryness. I now have very tender breasts, a constant mild headache, and swelling, tenderness, and dryness of the external genitalia almost since the first day that I started using the cream. The only good effect so far is that my libido does seem to be heightened. So now I feel 'sexy' again but can't do anything about it because of all my discomfort! I plan on continuing to use the cream at every third day intervals for 2 more weeks to see if my side effects subside. If I am still miserable, I will stop the medication and look for a non-prescription vaginal moisturizer as my last hope for a continued sex life."

• Cin...
• July 3, 2015

For Atrophic Vaginitis "I started using Estrace two years ago after major perimenopause symptoms. Around this time, my periods stopped, and I did find quite a bit of relief from vaginal and urethral pain and dryness, as well as frequent urination and burning. Have gotten along fairly well with several short flare-ups until recently when I have had a return of my symptoms even though I am still using the Estrace. Any suggestions or experience with this?"

• Cra...
• Taken for 1 to 6 months
• October 25, 2017

For Atrophic Vaginitis "I had a hysterectomy 10 years ago and having a dryness problem, so the doctor prescribed this. After using this for about 6 weeks, I started cramping like I was beginning to start my period again, and my breasts were hurting so bad, just like the old days! I called my doctor and was taken off of it immediately due to previous breast cancer, and she said the estrogen from it gets into the bloodstream."

• Anonymous
• Taken for 2 to 5 years
• April 19, 2023

For Atrophic Vaginitis "I have been using the generic brand Estrace, 1g twice a week for three and a half years to alleviate the symptoms of vaginal atrophy caused by menopause, including dryness, burning, and itching. Initially, sex was comfortable until my husband's low testosterone and low libido issues caused a significant decrease in our sexual activity. As a result, my vagina has narrowed and shortened due to lack of use, causing painful intercourse, despite continuing the use of Estrace. I plan to increase my Estrace dosage for a few weeks to address these changes and improve the discomfort during sex. It is ironic that my husband's low libido has led to my discomfort, which now irritates him. Technically, it is his fault that we did not engage in sexual activity regularly, leading to these issues."

• men...
• September 16, 2009

For Hypoestrogenism "Had trouble with sex, dryness, reduced libido, etc., this cream really helped!"