Estrace Vaginal Cream and Swelling: What Users Say

• Ell...
• Taken for 2 to 5 years
• September 21, 2020

For Atrophic Vaginitis "Horrible itching, burning, swelling from any topical estrogen I tried - Estrace, Vagifem, Premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - VERSABASE is hypoallergenic. I AM CURED - the compounded Estriol in VERSABASE has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use Estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!"

• amy...
• October 12, 2019

For Atrophic Urethritis "I used this once 3 weeks ago. Immediately had horrible burning and was up all night with what felt like a UTI. Am now on my 3rd antibiotic due to the inflammation and feel like these symptoms will never go away. It may be a Godsend for some, but if you are allergic, it is a nightmare."

• Not...
• October 7, 2015

For Atrophic Vaginitis "I have been using 1 mg every night for 12 days and am not sure if I can tolerate my side effect symptoms much longer to see if the cream actually works to diminish extremely painful intercourse due to dryness. I now have very tender breasts, a constant mild headache, and swelling, tenderness, and dryness of the external genitalia almost since the first day that I started using the cream. The only good effect so far is that my libido does seem to be heightened. So now I feel 'sexy' again but can't do anything about it because of all my discomfort! I plan on continuing to use the cream at every third day intervals for 2 more weeks to see if my side effects subside. If I am still miserable, I will stop the medication and look for a non-prescription vaginal moisturizer as my last hope for a continued sex life."

• Ano...
• Taken for 6 months to 1 year
• May 2, 2023

For Atrophic Vaginitis "I have been using a pea-sized amount of generic Estrace since Sept 2022. I have had burning and inflammation. After visiting four different gynecologists, all of whom kept telling me it can't be the Estrace, I finally found a doctor in the next state over who actually listened. A biopsy showed inflammation from irritant contact dermatitis. Heading to a dermatologist this week, hopefully for patch testing. Now awaiting the arrival of compounded estrogen."