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User Reviews for Estrace Vaginal Cream to treat Atrophic Vaginitis

Estrace Vaginal Cream has an average rating of 6.5 out of 10 from a total of 53 ratings for the treatment of Atrophic Vaginitis. 53% of reviewers reported a positive effect, while 25% reported a negative effect.

Estrace Vaginal Cream Rating Summary

6.5/10 average rating

53 ratings from 61 user reviews.

Compare all 42 medications used in the treatment of Atrophic Vaginitis.

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Reviews for Estrace Vaginal Cream

Ellie · Taken for 2 to 5 years September 21, 2020

“Horrible itching, burning, swelling from any topical estrogen I tried - estrace, vagifem, premarin. After 3 years of suffering, all with normal cultures (no infection), I insisted on biopsy of vulva - showed probable hypersensitivity reaction from allergy!!! Stopped all estrogens, but atrophic vaginitis returned with different burning and dryness, and painful sex. Then researched and found out that topical estrogens can cause all my symptoms from allergic reaction to the preservatives and other ingredients! My gyn had no clue. I researched this, and told doctor to order Estriol cream in VERSABASE cream base - versabase is hypoallergenic. I AM CURED - the compounded estriol in versabase has fixed my atrophic vaginitis without allergic reaction. I have my vagina back! Find a compounding pharmacy - I use estriol 1 mg/gram compounded - daily x 2 weeks then twice a week. Call around as the different compounding pharmacies have huge price differences for the same compound. Good luck!!!!”

1 / 10
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Jlady May 28, 2013

“I'm 71 years old. The tearing and associated pain started a few months ago. Just hoped it would go away but it did not. I would not let my husband touch me. Spoke with 2 doctors I know and they said its normal but Estrace would help. It did. My prescription is dated 3/7/2013. Within 10 days the tearing stopped and all was healed. Use 1 gram 3 X a week. Nothing bad has happened. My libido near immediately was through the roof. I am amazed and nobody needs to try and take this medicine away from me! I'm loving it and my husband is happy too. Yes, my age up there is right.”

10 / 10
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twistedK · Taken for less than 1 month January 23, 2016

“So - I was prescribed this and was shocked when I went to the pharmacy and she said $135. Dr. never mentioned this. I said "doesn't my insurance pay anything on this?" She checked and said "It's normally $350.00" or something. I was really angry. Angry, embarassed and this whole experience is humiliating to women. Why do I think a prescription of Viagra has a co-pay of like $10?? IT'S TIME TO STOP DISCRIMINATING AGAINST WOMEN. Especially us older women!!! That is ridiculous!!! I did not buy it, I was so angry. I may.... but I doubt it. I was prescribed this with an oral progesterone -- any one have experience with these two items combined? Thanks for letting me air that - take heed, Big Pharma.”

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letmepost654 · Taken for 5 to 10 years July 16, 2013

“I'm 65 and had ovaries removed 11 years ago, along with uterus and cervix. Since that, I have almost no sex drive and intercourse was super painful. Estrace vaginal cream really helps, and I only have to use a pea sized dab every other day. Just using a finger to apply at bedtime works great. It seems to me that the dire warnings about using estrogens is misleading since no studies have been done on just vaginal estradiol rather than on oral estrogen, and much higher doses are still prescribed than are needed for maintenance. Without Estrace vaginal cream, intercourse would be impossible and husband would be very unhappy. ”

10 / 10
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Sara55 · Taken for less than 1 month December 30, 2019

“I was using Estrace and was doing very well. Then they approved the generic Estradiol. I can already tell the difference. I’m itching and sex is painful again. Estrace is too expensive now that the generic has been released. Also Allergen offered free applicators but Mylan won’t even answer an e- mail regarding this. I think it VERY unsanitary to expect one to reuse the tubes. Allergen won’t even respond when I asked if I could buy the applicators for the generic- I did find them on Amazon for $33 a bag. Thinking about paying full price for the Estrace to get the free applicator program again. I’m going to try this generic a few more times. If I don’t see improvement and still have issues, I’m stopping it and reporting it to the FDA. Does anyone else have problems with generic but was doing great on Estrace brand??”

8 / 10
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Gram · Taken for 1 to 6 months June 6, 2019

“I am 71 years old and my doctor prescribed estradiol for vaginal atrophy. I was reluctant to try it but my symptoms worsened so I started the estradiol 3 times a week. After a few weeks I was symptom-free and feeling great. However after 3 months my symptoms gradually returned and now I have burning all day and the urination urgency off and on during the day. My symptoms abate at night. My doctor doesn’t have any answers as to why the medication stopped working. Does anyone else have this problem and what was your solution.?”

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Dc March 22, 2021

“I felt like I had a UTI for several months and was losing sleep due to the sensation of needing to urinate constantly. There were also lots of BV and yeast infections so it was frustrating. I found an official OBGYN who was a God send. I’m replying early on with this medicine because after a few days all of the old symptoms were gone. Into it a bit over a week and feel normal again. When I started it I think I was so dried out that my skin could not even absorb this internally as I’d see it the next morning (I assume it was the cream), but even with that - it has helped and I hope they don’t stop prescribing. Quality of life and comfort is important for mood stabilization etc. No point in living to be 100 if it’s painful everyday. Love this cream.”

10 / 10
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Frequently asked questions

Anon · Taken for 2 to 5 years June 19, 2018

“For those who commented about burning from using Estrace...I also had burning from it. My research led me to believe that the propylene glycol and/or glycerin in the product were the culprits. I switched to a hypoallergenic form of estradiol from a good compounding pharmacy and that solved the problem. No burning and the estradiol was so helpful.”

9 / 10
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Sexpert March 30, 2016

“Very sexually active until severe abrupt menopausal symptoms at 55. AV symptoms the most bothersome as overnight I shrunk up, dried up, itched, burned and tore. Intercourse was out of the question. Dr. gave me a sample of Estrace Vaginal cream. I admit I was afraid to use it and had little faith that it would help so I used only a pearl size amount on clean dry skin every night for 2 weeks. That ammt. Is sufficient to cover all the external parts and more, it emulsifies. I am COMPLETELY healed as far as pain with intercourse and also pain upon urination. It was a MIRACLE for me. Side note: If you stop using it (3X a week after the initial 2wk nightly use) you'll be back at square 1. I give Estrace a 10+ rating C: A tube lasted 6 months”

10 / 10
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CeeGal · Taken for 1 to 6 months December 16, 2016

“I've been married for 35 years. After menopause, intercourse became impossible due to dryness and pain. I do not go to the doctor as often as I should, so I suffered for years, and tried to find "natural remedies" on my own to no avail. I finally gave in and went to a gynecologist. I was embarrassed to even tell him, but I knew I had to do something. He was familiar with the problem and put me on Estrace cream. Within days, I was a NEW person. Saved my life and my marriage. Excellent results and fast!”

10 / 10
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Leyaleo · Taken for 1 to 6 months September 3, 2014

“Just posting an update from my last post a few months ago. The hypoallergenic estradiol (basically, a compounded version of Estrace from a compounding pharmacy) continues to be very effective for me - relieving vaginal burning/pain and urinary urgency/frequency. For women out there suffering those issues in perimenopause (when it hit me), know that it was suggested that I had interstitial cystitis and that I was off-base when I told doctors I was reacting badly to propylene glycol and glycerin, ingredients in many vaginal products. The compounded version of Estrace has been SO helpful for me and after many painful, difficult months, I feel myself again. ”

9 / 10
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denah November 18, 2013

“I am 50 yrs old and post menopausal - basically in full menopause.. I was prescribed this cream for thinning of the vaginal wall. I had increased urinary tract infections. I believe it helps with my libido which had dropped to zero! I hope this review helps. I didn't have dryness or pain with intercourse. My urologist prescribed it for me. It is really great to have doctors who "KNOW" what we are going through as females.”

10 / 10
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InPain · Taken for less than 1 month September 28, 2019

“I am 53 and had a complete hysterectomy 27 years ago and have been taking oral Premarin. Dr. Put me on the Estradiol patch which gave me headaches so we just stopped all HRT. Few weeks later I developed a UTI and had extreme vaginal and urethra pain. Was put on Estradiol Cream which irritated all of my skin, so they switched me to Estradiol vaginal tablets. I have been using it for 10 days and I am burning, aching and it feels like something is stuck in me. I do not like this cream and am wondering if the Premarin cream would work better. I keep wondering if this pain will ever go way. Has anyone had symptoms for over 10 days while using the cream?”

1 / 10
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His Wife is back!!! November 15, 2015

“I was experiencing very painful intercourse with tearing. I have used this medication exactly 3 times it has improved sex 99% already. Some pain on insurtion, but none during intercourse for the first time in years! I have no doubt it will get better as my body's estrogen levels improve.. So thankful. I am 55 yrs old.”

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Anonymous October 20, 2017

“Help! Can anybody who has had burning after using this horrible creme tell me how long does the burning last? Anyway how do you stop the burning? I put it in once and have been burning for 24 hours... any way to stop the burn??”

1 / 10
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debzaranti December 15, 2008

“I'm a 56 year old postmenopausal woman. I've been postmenopausal for 4 years and have been using Estrace for the last 2 years. I use a minimal amount (2mg once a week). This has greatly helped with my vaginal dryness, as well as keeping the hot flashes in check (a surprising, yet unexpected side benefit). I have had no bad side effects I am aware of. Prior to using Estrace I was taking 2 or 3 oral hormones (with some side-effects), plus I was paranoid about the cancer risk with those. I discontinued the oral hormones and tried using NO hormones for about 6 weeks and couldn't stand it, so my doctor prescribed Estrace.”

9 / 10
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menopausal lady August 10, 2018

“This cream has been a miracle. I had a hysterectomy 20 years ago and have been off estrogens for at least 15 years. About five years ago started having all kinds of vaginal discomfort. I think I was also battling a bacterial infection. Tried everything for that too. Finally settled on using boric acid capsules once a week for quite some time and the estrace three times a week. I used about 1gram. After several months finally I was able to stop the boric acid. I also was able to cut my estrace back to once a week 1gram. Before using this I was so sensitive that I would be burning and itching just from wiping with toilet paper. The tissue was so thin it looked shrivelled up down there. I noticed I had what appeared to be blood blisters on my labia which have gone away. The skin has plumped up too and is so much healthier. I would give this a ten except the cost is ridiculous.”

9 / 10
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Tennessee gal · Taken for less than 1 month May 15, 2014

“I'm 48 years old, and my Doctor has recently prescribed me Estrace Vaginal Creme because intercourse was becoming unbearable. Very painful and I was tearing! Geez! So far, the vaginal pain and dryness seems to be decreasing, as I've been only using the creme for the past month. I have no side effects at all so far. That's a good thing! However, I do find the creme very expensive!”

9 / 10
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Leyaleo · Taken for 1 to 6 months June 9, 2014

“At 46, I began having UTI's, urinary frequency/urgency, and burning vaginal dryness. I was prescribed Estrace, but the standard formula caused me burning as well. However, a compounded version of estradiol in a hypoallergenic formula has been very helpful. My vaginal burning has stopped, and the urinary urgency/frequency has improved dramatically over the last 2+ months. I think Estrace can be very helpful, and if you're sensitive to it (the propylene glycol can be an irritant), a compounded version can be extremely helpful.”

8 / 10
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bgkaufman · Taken for 5 to 10 years February 29, 2020

“The last 2 times when I used Estrace cream, I had bad burning and felt like I had a UTI. Out of desperation, I decided to try a vaginal yeast infection cream w/applicator to see if it made a difference. It did, both times!! Within hours, the symptoms decreased. By the next day, no further issues. Had no idea others had burning from the Estrace cream until I got on this site. May check out getting it compounded. I wonder why after years of using the Estrace (brand name), did this start all of the sudden. Have the ingredients changed??”

1 / 10
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CocopNP January 21, 2018

“I am a health care provider in women's health and I prescribe this like crazy. Vaginal atrophy is no joke. Some people are allergic to whatever else that is in the cream, but for the most part is well-tolerated. It is estradiol, which is identical to the estrogen in your body ”

10 / 10
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Mialo February 14, 2017

“The patches stopped working so this was last on the list to try. Dr. gave me a sample to try. Not very effective and Way Way overpriced. Will be trying compounded version. Wake up drug companies there are a lot of us baby boomers suffering from menopause who will not go quietly into the night. Especially when we're expected to keep working until 66.”

1 / 10
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Anonymous October 30, 2009

“I'm 58 and recently started on this medicine. Almost immediate relief of vulvar dryness and pain. Not sure yet if the painful intercourse will be relieved but this looks optimistic to me after many months of intense pain. Medicine does not seem gooey or even noticeable when used. Really like it so far.”

9 / 10
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Sebastian · Taken for 2 to 5 years August 12, 2020

“It's just okay with decreasing dryness, I still need to use other over the counter lubricants, but, this cream has brought back my sex drive! It stimulates my girl libido big time! So for that, I love this product!”

8 / 10
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Anonymous August 24, 2011

“I am 59 and postmenopausal. Started using the Estrace cream yesterday. I have other health issues (Licken sclerosis) which are bothersome. The cream almost instantly increased my libido and relieved the dryness. I am prescribed 1/2 gram intravaginally once to twice weekly. I hope it continues to help my condition.”

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Atrophic Vaginitis

Symptoms and treatments

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