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Premarin and Headaches: What Users Say

Headaches: mentioned by 5 users (6.0%)

Based on user experiences from 84 Premarin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 21.4%
hair loss 8.3%
night sweats 8.3%
headaches 6.0%
mood swings 6.0%
bloating 4.8%
dizziness 4.8%
pain 4.8%
anxiety 3.6%
depression 3.6%

Reviews for Premarin

Commonly mentioned side effects
  • Mag...
  • July 7, 2013

For Hypoestrogenism "I had a hysterectomy in 1980 and have been on Premarin 1.25 mg for 33 years and have no problems at all. I love my Premarin. I hope I can keep getting Premarin because there have been times doctors give you a hard time and I need to keep taking it. I have terrible withdrawals. So I need it. I get awful headaches and pain."

10 / 10
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115 Report
  • cdl...
  • February 13, 2012

For Atrophic Vaginitis "I've been on it almost 3 years. I had to start using this in my mid-twenties. I can use very little to the normal amount every 3 days or so. I go by how I feel more than anything. I do notice belly swelling the next day, and I do get headaches if I use too much. Other than that, I love this, and I'll keep using it. Make sure you get your yearly check-ups/blood work, and you'll be fine."

9 / 10
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54 Report
  • Car...
  • November 19, 2014

For Atrophic Vaginitis "I was prescribed Premarin vaginal cream to use for 2 weeks prior to my pap. I had a total hysterectomy 9 months ago. I experienced severe acid stomach from this medicine. I have a history of stomach acid, so I didn't put the 2 together. I took my usual meds, avoided food that could trigger acid, but to no avail. I suffered for 5 days of severe acid stomach until I decided to stop the cream that night. The following day, my stomach was still sore but not acidic. I woke up with a headache. I didn't think the cream would affect me this way since its effects are limited to the vaginal area. I was wrong. I can confirm that my acid stomach was due to Premarin vaginal cream."

6 / 10
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27 Report

Frequently asked questions

  • Tan...
  • Taken for 6 months to 1 year
  • February 3, 2022

For Oophorectomy "Unnecessary oophorectomy performed 2000, age 50, still having periods. Hysterectomy too, due to fibroids. Now discover that it's possible to remove fibroids, leaving womb intact! Suffering terribly from symptoms, given 1 mg of Premarin. Over three years, I started with severe headaches resulting in projectile vomiting! I was working at the time, so came off it entirely. No good! I tried different drugs, given Climaval, fantastic! Felt driven, confident, marvelous. Hair and skin glowing again. So, MHRA in the UK removed this drug from the market. I tried many more, I am placed on Premarin 0.3, which makes me feel nauseous, appetite affected as a result, and have arthritic pain. However, I stick it out as, mentally, I don’t feel too bad. The sickness fades, I am now stuck with bloating, flatulence, which is noisy and uncontrollable. Why aren’t side effects removed from these drugs?"

4 / 10
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3 Report
  • tin...
  • Taken for less than 1 month
  • February 21, 2023

For Postmenopausal Symptoms "It's been two nights since I took the first dose of vaginal cream (1/2 gram) for vaginal pain. Since taking it, I have developed terrible anxiety, felt spacey all day, had a headache, and had trouble sleeping. My reflux, which was under control with Pepcid, has worsened. My doctor does not think these are side effects of the medication, but I do not believe that. Maybe the side effects will get better after more doses, but I am reluctant to continue using Premarin."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.