Urinary antispasmodics
What are Urinary antispasmodics?
Urinary antispasmodics are the name given to a group of medicines that block the effects of acetylcholine and inhibit involuntary detrusor muscle contractions. The detrusor muscle is found in the wall of the bladder. Urinary antispasmodics are used to treat symptoms of urge incontinence and overactive bladder.
Acetylcholine is the main neurotransmitter of the parasympathetic nervous system (also called the cholinergic system). The parasympathetic nervous system regulates various organ and gland functions at rest, including digestion, defecation, lacrimation, salivation, and urination.
Acetylcholine acts on two types of receptors; nicotinic and muscarinic cholinergic receptors. Some urinary antispasmodics are non-selective, which means they bind to both nicotinic and muscarinic receptors. Others selectively block M3 (a specific type of muscarinic receptor). Selective antispasmodics cause less drowsiness than non-selective antispasmodics but may cause more constipation, dry mouth, and blurred vision.
List of Urinary antispasmodics
Drug Name |
Avg. Rating |
Reviews |
oxybutynin systemic (Pro) Brand names: Ditropan XL, Gelnique, Oxytrol |
|
454 reviews |
mirabegron systemic (Pro) Brand name: Myrbetriq |
|
352 reviews |
solifenacin systemic (Pro) Brand names: VESIcare, VESIcare LS |
|
199 reviews |
vibegron systemic (Pro) Brand name: Gemtesa |
|
184 reviews |
fesoterodine systemic (Pro) Brand name: Toviaz |
|
77 reviews |
tolterodine systemic (Pro) Brand names: Detrol, Detrol LA |
|
76 reviews |
trospium systemic (Pro)
|
|
66 reviews |
hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate systemic Brand names: Azuphen MB, Hyolev MB, Phosphasal, Urelle, Uretron DS, Uribel, Urimar-T, Urin D/S, UrNeva, Uro-458, Uro-MP, Uro-SP, UroAv-81, UroAv-B, Ustell, UTICAP, Utira-C, Utrona-C, Vilamit MB, Vilevev MB |
|
43 reviews |
darifenacin systemic (Pro)
|
|
25 reviews |
hyoscyamine / methenamine / methylene blue / sodium biphosphate systemic Brand names: Urogesic Blue, Uta |
|
15 reviews |
benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate systemic (Pro) Brand names: Hyophen, Urised |
|
7 reviews |
flavoxate systemic (Pro)
|
|
4 reviews |
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). |
See also
Medical conditions treated or associated with urinary antispasmodics:
Further information
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