Trospium Dosage

Medically reviewed by Drugs.com. Last updated on Aug 8, 2023.

Usual Adult Dose for Urinary Incontinence

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Incontinence

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Frequency

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

Immediate-release formulation:

• Mild to moderate renal impairment (CrCl 30 to less than 90 mL/min): No adjustment recommended.
• Severe renal impairment (CrCl less than 30 mL/min): 20 mg orally once a day at bedtime

Extended-release formulation:

• Mild to moderate renal impairment (CrCl 30 to less than 90 mL/min): No adjustment recommended.
• Severe renal impairment (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Immediate-release formulation:

• Mild to moderate hepatic impairment: No adjustment recommended.
• Severe hepatic impairment: Caution recommended.

Extended-release formulation:

• Mild hepatic impairment: No adjustment recommended.
• Moderate to severe hepatic impairment: Caution recommended.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients (e.g., angioedema, rash, anaphylactic reaction)
• Urinary retention
• Gastric retention
• Uncontrolled narrow-angle glaucoma

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be given 1 hour before meals or on an empty stomach.
• This drug should be taken with water.

Storage requirements:

• Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
• Protect from light.

Patient advice:

• Do not drive or operate machinery until you know how this drug affects you.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer