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Trospium Dosage

Medically reviewed by Drugs.com. Last updated on Aug 11, 2020.

Applies to the following strengths: 20 mg; 60 mg

Usual Adult Dose for Urinary Incontinence

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Incontinence

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Frequency

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

Immediate-release formulation:
-Mild to moderate renal impairment (CrCl 30 to less than 90 mL/min): No adjustment recommended.
-Severe renal impairment (CrCl less than 30 mL/min): 20 mg orally once a day at bedtime

Extended-release formulation:
-Mild to moderate renal impairment (CrCl 30 to less than 90 mL/min): No adjustment recommended.
-Severe renal impairment (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Immediate-release formulation:
-Mild to moderate hepatic impairment: No adjustment recommended.
-Severe hepatic impairment: Caution recommended.

Extended-release formulation:
-Mild hepatic impairment: No adjustment recommended.
-Moderate to severe hepatic impairment: Caution recommended.

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients (e.g., angioedema, rash, anaphylactic reaction)
-Urinary retention
-Gastric retention
-Uncontrolled narrow-angle glaucoma

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be given 1 hour before meals or on an empty stomach.
-This drug should be taken with water.

Storage requirements:
-Store at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
-Protect from light.

Patient advice:
-Do not drive or operate machinery until you know how this drug affects you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.